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RAPT Therapeutics, Inc. (NASDAQ: RAPT) is a clinical-stage biopharmaceutical company specializing in immunology-based treatments. Focused on developing and commercializing oral small molecule therapies, RAPT Therapeutics aims to address significant unmet medical needs in oncology and inflammatory diseases. Utilizing its proprietary discovery and development engine, the company creates highly selective small molecules designed to modulate critical immune drivers underlying these conditions.
RAPT Therapeutics has two main drug candidates: FLX475 (tivumecirnon) and RPT193 (zelnecirnon). FLX475 targets the C-C motif chemokine receptor 4 (CCR4) and is designed to inhibit the migration of regulatory T cells into tumors, enhancing the immune response against cancer. RPT193, also targeting CCR4, focuses on inhibiting type 2 T helper cells in inflamed tissues, offering potential relief for inflammatory diseases like atopic dermatitis and asthma.
In recent developments, RAPT Therapeutics reported promising Phase 2 data for FLX475 in combination with pembrolizumab for non-small cell lung cancer (NSCLC) patients. The company also emphasized FLX475's potential in other cancers, including head and neck cancer, gastric cancer, and non-Hodgkin lymphoma. Despite a clinical hold placed by the FDA on the Phase 2 trials for zelnecirnon due to a serious adverse event, RAPT continues to investigate and aims to resolve the issue.
Financially, RAPT Therapeutics maintains a strong cash position, reporting $158.9 million in cash and equivalents by the end of 2023. The company is diligently working to advance its clinical programs and explore additional targets in the discovery stage, ensuring a robust pipeline for future developments.
RAPT Therapeutics has reported promising biomarker data from its Phase 1b trial of RPT193 for moderate-to-severe atopic dermatitis, presented at the American Academy of Dermatology Annual Meeting. Key findings indicate a statistically significant improvement in the meta-analysis derived atopic dermatitis (MADAD) score (p<0.001) and positive changes in immune pathways linked to the disease. RAPT aims to initiate a Phase 2b clinical trial in atopic dermatitis, with plans to expand RPT193's development into asthma.
RAPT Therapeutics, Inc. reported its financial results for Q4 2021 and the full year, highlighting a net loss of $17.9 million for Q4 and $69.2 million for the year, an increase from $12.7 million and $52.9 million in 2020, respectively. R&D expenses rose to $14.3 million in Q4 and $57.0 million for the year due to clinical trial costs for RPT193 and FLX475. General and administrative expenses also increased to $4.5 million in Q4 and $16.0 million for the year. The company maintained a robust cash position of $189.7 million as of year-end.
SOUTH SAN FRANCISCO, Calif., Feb. 09, 2022 – RAPT Therapeutics, a clinical-stage biopharmaceutical company, announced that Brian Wong, M.D., Ph.D., President and CEO, will participate in a virtual fireside chat at the 11th Annual SVB Leerink Healthcare Conference on February 16, 2022, at 1:40 p.m. ET. The event will discuss the company's focus on developing oral small molecule therapies for inflammatory diseases and oncology. Interested parties can access the live or archived webcast on the RAPT Therapeutics website.
SOUTH SAN FRANCISCO, Calif., Jan. 04, 2022 – RAPT Therapeutics, Inc. (Nasdaq: RAPT), a clinical-stage biopharmaceutical company, announced that President and CEO Brian Wong, M.D., Ph.D., will present at the 40th Annual J.P. Morgan Healthcare Conference. The event will take place on January 11, 2022, at 9:00 a.m. ET. RAPT focuses on developing oral small molecule therapies for inflammatory diseases and oncology. The company has advanced drug candidates RPT193 and FLX475, targeting CCR4 for treating inflammation and cancer. Access the presentation via the RAPT website.
RAPT Therapeutics reported a net loss of $18.7 million for Q3 2021, up from $14.6 million in Q3 2020. Research and development expenses rose to $15.7 million due to clinical trial costs for FLX475 and RPT193. Total net loss for the nine months ended September 30, 2021, was $51.3 million, compared to $40.2 million in the prior year. RAPT aims to advance RPT193 into Phase 2 trials in 2022 and is focusing on FLX475 for various cancers, with data updates expected at a medical meeting in 2022. The company holds $210.8 million in cash and securities.
RAPT Therapeutics, a clinical-stage biopharmaceutical company, has appointed Lori Lyons-Williams to its Board of Directors. With over 20 years of experience, she previously held key roles at Neumora Therapeutics and Dermira, driving strategic success in biotechnology. Her expertise is expected to significantly benefit RAPT's inflammation and oncology product pipeline, particularly RPT193. RAPT develops oral small molecule therapies for patients with severe unmet needs, focusing on inflammatory diseases and cancer.
RAPT Therapeutics, based in South San Francisco, announced that CEO Brian Wong will present at key investor conferences in November 2021. These include the Stifel 2021 Virtual Healthcare Conference on November 15 at 2:00 p.m. ET and the Piper Sandler 33rd Annual Virtual Healthcare Conference on November 22 available on-demand at 10:00 a.m. ET. RAPT Therapeutics focuses on developing oral small molecule therapies for inflammatory diseases and oncology, with drug candidates like RPT193 and FLX475 targeting CCR4.
RAPT Therapeutics, Inc. (Nasdaq: RAPT) announced the presentation of clinical efficacy data from its Phase 1b trial of RPT193, an oral CCR4 inhibitor for moderate-to-severe atopic dermatitis. The presentation will occur at the 4th Inflammatory Skin Disease Summit in New York, from November 3-6, 2021. The trial is designed to demonstrate the efficacy of RPT193 compared to a placebo. This is part of RAPT's commitment to developing therapies for significant unmet needs in oncology and inflammatory diseases.
RAPT Therapeutics announced positive topline results from its Phase 1b clinical trial of RPT193 for moderate-to-severe atopic dermatitis, presented at the EADV Congress. The trial demonstrated significant efficacy across key exploratory endpoints including EASI and vIGA, with benefits observed persisting two weeks post-treatment. RPT193 was well tolerated, showing a clean safety profile with no serious adverse events. The company plans to advance RPT193 to a Phase 2b trial in atopic dermatitis and a Phase 2a trial in asthma, highlighting its potential in treating inflammatory diseases.
RAPT Therapeutics, a clinical-stage biopharmaceutical company, announced that CEO Brian Wong will present at the 2021 Cantor Virtual Healthcare Conference on September 27, 2021, at 2:00 p.m. EST. The company focuses on developing oral small molecule therapies for unmet needs in oncology and inflammatory diseases, with two drug candidates, FLX475 and RPT193, targeting CCR4 receptors. For access to the live webcast and archived recordings, visit the RAPT Therapeutics website.
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