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About RAPT Therapeutics, Inc.
RAPT Therapeutics, Inc. (NASDAQ: RAPT) is a clinical-stage biopharmaceutical company specializing in the development of immunology-based therapies designed to address significant unmet needs in oncology and inflammatory diseases. Headquartered in South San Francisco, California, RAPT leverages its proprietary discovery and development platform to identify and advance highly selective small molecule therapies that modulate critical immune drivers underlying complex diseases. By focusing on precision medicine, the company aims to deliver novel, oral therapeutic options that improve patient outcomes.
Proprietary Discovery Platform
At the core of RAPT's operations is its proprietary discovery and development engine, which integrates advanced computational biology, immunology, and medicinal chemistry. This platform enables the identification of highly selective drug candidates targeting key immune pathways. By focusing on the modulation of immune system components, RAPT addresses both the underlying causes of disease and the limitations of current therapeutic options. This innovative approach has led to the development of drug candidates with the potential to transform the treatment landscape for oncology and inflammatory diseases.
Pipeline and Key Drug Candidates
RAPT’s pipeline includes two lead drug candidates, both targeting the C-C motif chemokine receptor 4 (CCR4):
- Tivumecirnon (FLX475): A CCR4 antagonist designed to block the migration of regulatory T cells (Treg) into tumors. By restoring antitumor immunity, tivumecirnon holds promise as a monotherapy and in combination with immune checkpoint inhibitors for various cancers, including non-small cell lung cancer, head and neck cancer, and gastric cancer.
- Zelnecirnon (RPT193): A CCR4 antagonist aimed at inhibiting the migration of type 2 T helper cells into inflamed tissues. While initially developed for atopic dermatitis and asthma, the program faced challenges due to safety concerns, leading to clinical holds. Despite this, RAPT continues to explore next-generation CCR4-targeting compounds with improved safety profiles for inflammatory diseases.
In addition to these candidates, RAPT is actively expanding its pipeline through preclinical programs and strategic collaborations. The recent licensing agreement for RPT904, a half-life extended anti-IgE monoclonal antibody, exemplifies the company’s commitment to addressing allergic inflammatory diseases such as food allergies and chronic spontaneous urticaria.
Market Position and Competitive Landscape
RAPT operates in the highly competitive biopharmaceutical industry, where innovation and precision medicine drive success. By focusing on small molecule therapies and leveraging its proprietary platform, RAPT differentiates itself from competitors relying on biologics or less targeted approaches. The company’s emphasis on addressing unmet medical needs in oncology and inflammatory diseases positions it as a significant player in these growing markets. Strategic partnerships and licensing agreements further enhance its market reach and pipeline diversity.
Challenges and Opportunities
As a clinical-stage company, RAPT faces challenges typical of its industry, including regulatory hurdles, clinical trial risks, and competition from established and emerging biopharmaceutical firms. However, its proprietary platform, selective targeting of immune pathways, and strategic collaborations provide a strong foundation for overcoming these challenges. By addressing safety concerns and advancing next-generation compounds, RAPT continues to demonstrate its resilience and commitment to innovation.
Conclusion
RAPT Therapeutics, Inc. represents a forward-thinking approach to immunology-based drug development. With a focus on precision medicine, a robust discovery platform, and a growing pipeline of innovative therapies, the company is well-positioned to make a meaningful impact on the treatment of oncology and inflammatory diseases. While challenges persist, RAPT’s strategic initiatives and commitment to addressing unmet medical needs underscore its potential to transform patient care in these critical areas.
RAPT Therapeutics, a clinical-stage biopharmaceutical company focused on immunology, will have CEO Brian Wong participate in a fireside chat at the SVB Securities Global Biopharma Conference on February 14, 2023, at 1:40 p.m. ET. The event will discuss RAPT's efforts in developing oral small molecule therapies for inflammatory diseases and oncology, including their drug candidates RPT193 and FLX475, aimed at targeting C-C motif chemokine receptor 4 (CCR4). Investors and interested parties can access the live webcast and archived recording on RAPT's website.
RAPT Therapeutics, a clinical-stage biopharmaceutical company, announced that its CEO, Brian Wong, will present at the 41st Annual J.P. Morgan Healthcare Conference on January 10, 2023, at 3:00 p.m. PT. The conference provides a platform for companies to discuss innovations in healthcare. RAPT focuses on developing oral small molecule therapies for inflammatory diseases and oncology. Their notable drug candidates include RPT193 and FLX475, targeting CCR4 receptors. A live webcast of the presentation will be available on their official website.
RAPT Therapeutics presented promising data at the ESMO Immuno-Oncology Congress for its ongoing Phase 1/2 trial of FLX475, showing a confirmed overall response rate of 31% in checkpoint-naïve NSCLC patients, with ongoing responses exceeding one year. Among 13 patients, 38% of those with PD-L1 positive tumors responded, while 25% responded in the PD-L1 negative group. Additionally, a separate cohort of patients with EBV+ NK/T cell lymphoma displayed four responses, including two durable complete metabolic responses. The safety profile of FLX475 remained favorable.
RAPT Therapeutics (Nasdaq: RAPT) has announced that its abstract for the ongoing Phase 1/2 study of FLX475 will be presented at the European Society for Medical Oncology Immuno-Oncology Annual Congress from December 7-9, 2022, in Geneva, Switzerland. The presentation will cover data from patients with checkpoint inhibitor-naïve NSCLC treated with FLX475 plus pembrolizumab and those with EBV-positive NK/T cell lymphoma receiving FLX475 monotherapy. The session will occur on December 8, 2022, from 12:30 to 1:15 p.m. CET.
RAPT Therapeutics announced the pricing of an underwritten public offering of 4,054,055 shares of common stock at $18.50 per share, aiming to raise approximately $75 million before expenses. The offering will close on November 22, 2022. The underwriters have an additional option to purchase up to 608,108 shares. This offering falls under a shelf registration statement declared effective on November 16, 2020. The company focuses on developing oral small molecule therapies for inflammatory diseases and oncology, with drug candidates targeting CCR4.
RAPT Therapeutics has announced an underwritten public offering of $75 million in common stock, with an option for underwriters to purchase an additional $11.25 million. The offering, subject to market conditions, is being managed by J.P. Morgan, Evercore ISI, Guggenheim Securities, and Cantor. The shares will be offered under a previously declared effective registration statement by the SEC. This capital raise aims to support RAPT's continued development of oral small molecule therapies for inflammatory diseases and oncology.
RAPT Therapeutics, Inc. (Nasdaq: RAPT) reported a net loss of $21.2 million for Q3 2022, compared to $18.7 million in Q3 2021. Over the nine months ending September 30, 2022, the net loss totaled $60.9 million, an increase from $51.3 million year-over-year. Research and development expenses rose to $16.6 million for Q3 and $47.6 million for the nine months, driven by early-stage program costs. The company's cash position remains strong at $195.4 million, supporting ongoing clinical trials for RPT193 and FLX475.
SOUTH SAN FRANCISCO, Calif., Nov. 09, 2022 – RAPT Therapeutics (Nasdaq: RAPT) announced participation in three upcoming investor conferences in November. The conferences include the Guggenheim 4th Annual Immunology and Neurology Day on November 15, the Piper Sandler 33rd Annual Healthcare Conference on November 29, and the Evercore ISI 5th Annual Virtual HealthCONx Conference on November 30. Interested parties can access live webcasts and recordings through the RAPT Therapeutics website.
RAPT Therapeutics has announced the appointment of Jennifer Nicholson as Senior Vice President of Regulatory Affairs and Quality Assurance, and Adnan Rahman as Vice President of Commercial. These appointments come at a crucial time as the company progresses its RPT193 program into late-phase trials for atopic dermatitis and asthma, and continues developing FLX475 for various cancers. Both executives bring extensive experience from notable biopharmaceutical companies, which will enhance RAPT's regulatory and commercial strategies.
RAPT Therapeutics announced participation in key investor conferences throughout September 2022. The events include Citi’s 17th Annual Biopharma Conference on September 7, Wells Fargo Healthcare Conference on September 8 featuring a fireside chat with President and CEO Brian Wong, and H.C. Wainwright 24th Annual Global Investment Conference on September 12, available on-demand. RAPT is focused on developing small molecule therapies for inflammatory diseases and oncology, including drug candidates RPT193 and FLX475. For live webcasts, visit their website.
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