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Overview of IN8Bio, Inc.
IN8Bio, Inc. (Nasdaq: INAB) is a clinical-stage biotechnology company pioneering the development of gamma-delta T cell-based immunotherapies for the treatment of solid and liquid tumors. Leveraging the unique properties of gamma-delta T cells, the company focuses on creating innovative therapies that address significant unmet medical needs in oncology. Gamma-delta T cells are a specialized subset of T cells with the innate ability to differentiate between healthy and diseased tissues, making them a promising tool for targeted cancer treatment.
Core Business and Technology
IN8Bio's proprietary DeltEx platform employs allogeneic, autologous, and genetically modified approaches to develop gamma-delta T cell therapies. These therapies are designed to enhance tumor targeting, improve treatment durability, and reduce the risk of toxicities often associated with other immunotherapies. Unlike traditional CAR-T therapies, gamma-delta T cells naturally secrete lower levels of inflammatory cytokines, potentially offering a safer and more tolerable treatment option.
Key Clinical Programs
- INB-400: A Phase 2 clinical program targeting newly diagnosed glioblastoma (GBM), a highly aggressive brain tumor with limited treatment options. INB-400 combines autologous gamma-delta T cells with the standard-of-care regimen to improve progression-free and overall survival rates.
- INB-100: A Phase 1 program focused on high-risk leukemia patients undergoing hematopoietic stem cell transplantation. This therapy utilizes haplo-matched allogeneic gamma-delta T cells to reduce relapse rates and improve long-term outcomes.
- Preclinical Pipeline: The company is also exploring additional product candidates, such as INB-200 and INB-300, targeting other solid and hematologic tumors.
Market Position and Differentiation
IN8Bio operates within the competitive landscape of cell-based immunotherapies, which includes CAR-T therapies and other T cell-based approaches. However, the company differentiates itself through its focus on gamma-delta T cells, which offer unique advantages such as innate tumor recognition and reduced risk of severe toxicities like cytokine release syndrome (CRS). This positions IN8Bio as a potential leader in the next generation of immunotherapies.
Challenges and Opportunities
As a clinical-stage company, IN8Bio faces challenges such as regulatory hurdles, manufacturing scalability, and the inherent risks of clinical development. However, its innovative approach and focus on addressing unmet medical needs provide significant opportunities for growth and impact within the biopharmaceutical industry.
Conclusion
IN8Bio, Inc. represents a cutting-edge approach to cancer treatment, utilizing the unique properties of gamma-delta T cells to develop therapies with the potential to transform outcomes for patients with difficult-to-treat cancers. Through its robust pipeline and proprietary technology, the company is well-positioned to make a meaningful impact in the field of oncology.
IN8bio, Inc. (Nasdaq: INAB) has appointed Dr. Michael R. Bishop to its Scientific Advisory Board. Dr. Bishop is a renowned expert in cellular therapy and oncology, currently serving at the University of Chicago. His extensive experience in hematologic malignancies and stem cell transplantation is expected to bolster IN8bio’s development of gamma-delta T cell therapies. The company is advancing its clinical programs, including Phase 1 trials for glioblastoma and leukemia treatments, leveraging its DeltEx platform, which aims to enhance the efficacy of cell therapies.
IN8bio, Inc. (Nasdaq: INAB) announced its participation in several key conferences throughout September 2022. CEO William Ho will join the Cell Therapy Panel at Citi’s Annual BioPharma Conference in Boston on September 7. He will also partake in a Fireside Chat at H.C. Wainwright from September 12-15, with a session on September 14. Kate Rochlin, COO, will present at the BioProcess International Conference in Boston on September 28. Additionally, Lawrence Lamb, CSO, will present at the Sixth International Cancer Immunotherapy Conference in New York on September 30. IN8bio focuses on gamma-delta T cell therapies.
IN8bio, Inc. (Nasdaq: INAB) has reported that the underwriter of its recent public offering, which closed on August 16, 2022, partially exercised its option to purchase 268,949 additional shares at $1.90 each, adding approximately $0.5 million in gross proceeds. This brings the total number of shares sold to 5,663,686, with gross proceeds now totaling around $10.75 million. The offering was conducted under a registration statement declared effective on August 11, 2022.
IN8bio, Inc. (Nasdaq: INAB) successfully closed an underwritten public offering of 5,394,737 shares of its common stock at $1.90 per share, generating approximately $10.25 million in gross proceeds. The offering, managed by H.C. Wainwright & Co., included a 30-day option for the underwriter to purchase an additional 657,894 shares. This transaction was facilitated through a registration statement filed with the SEC, effective August 11, 2022. The funds are intended to support the company's clinical development of gamma-delta T cell therapies.
IN8bio recently announced a preclinical program for iPSC-derived gamma-delta T cells, presenting findings at the ASGCT Annual Meeting. The Phase 1 trial of INB-200 showed five of six patients exceeded expected progression-free survival (PFS), while two surpassed overall survival (OS) benchmarks. INB-100 Phase 1 trial data revealed two of three leukemia patients relapse-free at two years. The company appointed new executives to bolster its management team. Financially, R&D expenses rose to $3.5 million, with a net loss of $7.2 million for Q2 2022, and cash reserves decreased to $25.7 million.
IN8bio announced a public offering of 5,394,737 shares at $1.90 each, expected to close by August 16, 2022. The offering could generate approximately $10.25 million before expenses. H.C. Wainwright & Co. is the sole book-running manager, with an option for additional 657,894 shares. The registration statement was declared effective on August 11, 2022. IN8bio focuses on innovative gamma-delta T cell therapies for tumors, emphasizing its DeltEx platform's capabilities.
IN8bio, Inc. (Nasdaq: INAB) announced promising progress in its Phase 1 trial of INB-100 for high-risk relapsed acute myeloid leukemia (AML) patients. All three patients treated remain alive and disease-free for more than one year post-transplant, with two patients exceeding two years in complete remission. The therapy shows a manageable safety profile, with no severe adverse effects or dose-limiting toxicities reported. The data suggests potential for improved cure rates in AML without significant added risks, with further patient data expected later in 2022.
IN8bio, Inc. (Nasdaq: INAB) announced the issuance of a new European patent covering its Drug Resistant Immunotherapy (DRI) platform, expanding its intellectual property to include NK cells alongside gamma-delta T cells. This patent enhances IN8bio’s position in developing cellular therapies for solid tumors, emphasizing its innovative approach to combat cancer through genetically engineered immune cells. The company is actively advancing its pipeline, including ongoing Phase 1 trials for INB-200 and INB-100, aimed at treating glioblastoma and leukemia, respectively.
IN8bio, Inc. (Nasdaq: INAB) announced the appointment of Kenneth R. LaMontagne, Ph.D., as Senior Vice President of Business Development, aiming to enhance partnership strategies for gamma-delta T cell therapies. Dr. LaMontagne brings over 20 years of experience in cell therapies and oncology, with a history of significant transaction execution in his past roles at Artisan Bio and Bristol Myers Squibb. CEO William Ho emphasized the strategic importance of this leadership addition to increase shareholder value and advance the company's comprehensive pipeline in clinical development.
IN8bio (Nasdaq: INAB) has announced its participation in key conferences this July, focusing on its innovative gamma-delta T cell therapies. The company will present at the Oppenheimer Summit on July 20, with CFO Patrick McCall and CMO Dr. Trishna Goswami available for 1x1 partnering. Additionally, at the 3rd Annual Gamma-Delta T Cell Therapies Summit in Boston (July 26-28), CSO Lawrence Lamb will lead discussions and presentations on maximizing therapeutic outcomes. Lastly, CEO William Ho will deliver a keynote at the GEN Cell & Gene Therapy Summit on July 27.
FAQ
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