Welcome to our dedicated page for In8Bio news (Ticker: INAB), a resource for investors and traders seeking the latest updates and insights on In8Bio stock.
Overview of IN8Bio, Inc.
IN8Bio, Inc. (Nasdaq: INAB) is a clinical-stage biotechnology company pioneering the development of gamma-delta T cell-based immunotherapies for the treatment of solid and liquid tumors. Leveraging the unique properties of gamma-delta T cells, the company focuses on creating innovative therapies that address significant unmet medical needs in oncology. Gamma-delta T cells are a specialized subset of T cells with the innate ability to differentiate between healthy and diseased tissues, making them a promising tool for targeted cancer treatment.
Core Business and Technology
IN8Bio's proprietary DeltEx platform employs allogeneic, autologous, and genetically modified approaches to develop gamma-delta T cell therapies. These therapies are designed to enhance tumor targeting, improve treatment durability, and reduce the risk of toxicities often associated with other immunotherapies. Unlike traditional CAR-T therapies, gamma-delta T cells naturally secrete lower levels of inflammatory cytokines, potentially offering a safer and more tolerable treatment option.
Key Clinical Programs
- INB-400: A Phase 2 clinical program targeting newly diagnosed glioblastoma (GBM), a highly aggressive brain tumor with limited treatment options. INB-400 combines autologous gamma-delta T cells with the standard-of-care regimen to improve progression-free and overall survival rates.
- INB-100: A Phase 1 program focused on high-risk leukemia patients undergoing hematopoietic stem cell transplantation. This therapy utilizes haplo-matched allogeneic gamma-delta T cells to reduce relapse rates and improve long-term outcomes.
- Preclinical Pipeline: The company is also exploring additional product candidates, such as INB-200 and INB-300, targeting other solid and hematologic tumors.
Market Position and Differentiation
IN8Bio operates within the competitive landscape of cell-based immunotherapies, which includes CAR-T therapies and other T cell-based approaches. However, the company differentiates itself through its focus on gamma-delta T cells, which offer unique advantages such as innate tumor recognition and reduced risk of severe toxicities like cytokine release syndrome (CRS). This positions IN8Bio as a potential leader in the next generation of immunotherapies.
Challenges and Opportunities
As a clinical-stage company, IN8Bio faces challenges such as regulatory hurdles, manufacturing scalability, and the inherent risks of clinical development. However, its innovative approach and focus on addressing unmet medical needs provide significant opportunities for growth and impact within the biopharmaceutical industry.
Conclusion
IN8Bio, Inc. represents a cutting-edge approach to cancer treatment, utilizing the unique properties of gamma-delta T cells to develop therapies with the potential to transform outcomes for patients with difficult-to-treat cancers. Through its robust pipeline and proprietary technology, the company is well-positioned to make a meaningful impact in the field of oncology.
IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company, announced that CEO William Ho will present at the Jefferies Global Healthcare Conference on June 8, 2022, from 1:30 to 1:55 p.m. EDT. The presentation will focus on the company's innovative gamma-delta T cell therapies and its DeltEx platform. Additional upcoming presentations include the Biotechnology Innovation Organization International Convention and the Next Generation CAR & T Cell Therapies event. IN8bio is conducting Phase 1 clinical trials for INB-200 and INB-100, targeting glioblastoma and leukemia.
IN8bio, Inc. (Nasdaq: INAB) reported promising results from its Phase 1 trial for INB-200 in glioblastoma multiforme (GBM) patients. Notably, 100% of patients exceeded the median progression-free survival (PFS), with some exceeding overall survival (OS) expectations. One patient remains stable after one year post-enrollment. The safety profile was manageable with no severe adverse events reported. Enrollment for the third cohort has begun, with further updates anticipated later in 2022.
IN8bio announced the expansion of its DeltEx gamma-delta T cell platform to include induced pluripotent stem cells (iPSCs) at the ASGCT 25th Annual Meeting. Data revealed that iPSC-derived gamma-delta T cells exhibit robust cytotoxicity and can be genetically modified with an internal CAR-T construct, marking a significant advancement in the field. IN8bio is the first to demonstrate directed differentiation of both Vdelta1 and Vdelta2 sub-types. The company plans to host a webcast on May 17, 2022, to discuss these findings and its ongoing clinical programs.
IN8bio, Inc. (Nasdaq: INAB) reported encouraging results for its Phase 1 clinical trials of INB-100 and INB-200, focusing on leukemia and glioblastoma patients. At the EBMT Annual Meeting, all three INB-100 patients were in complete remission, with durable remissions between 9 to 23 months. INB-200 showed a manageable safety profile with no dose-limiting toxicities. Financially, cash decreased to $32.1 million, and R&D expenses rose to $2.4 million. The company experienced a net loss of $6.1 million for Q1 2022, compared to a loss of $3.1 million in Q1 2021.
IN8bio, Inc. (Nasdaq: INAB) announced the launch of its new iPSC-based gamma-delta T cell platform, making it one of the few companies able to create both Vdelta1 and Vdelta2 T cell subtypes. This platform aims to facilitate the scaled manufacturing of 'off-the-shelf' cellular therapies. CEO William Ho highlighted this as a significant advancement, with plans to present data at the ASGCT Annual Meeting from May 16-19, 2022. The company is also set to discuss ongoing clinical trials and its product pipeline during a workshop on May 17, 2022.
IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical firm, announced its participation in several conferences in May 2022. Highlights include presentations at the ISCT International Society for Cell & Gene Therapy and the Allogeneic Cell Therapies Summit, featuring topics on innovative gamma-delta T cell therapies. Key speakers include CEO William Ho and COO Kate Rochlin. The company also focuses on the DeltEx platform for developing gamma-delta T cell therapies targeting solid tumors and leukemia. IN8bio is conducting Phase 1 trials for products INB-200 and INB-100.
IN8bio (Nasdaq: INAB) announced the appointment of Urvashi Patel, Ph.D., as Vice President of Regulatory Affairs and Stacey Bilinski as Vice President of Clinical Operations. These appointments aim to enhance the company's clinical pipeline, with plans to file at least one new IND this year. Dr. Patel brings over 17 years of drug development experience, including cell therapy, while Ms. Bilinski has over 30 years in clinical operations. IN8bio is focused on developing innovative gamma-delta T cell therapies for cancer treatment.
IN8bio, a clinical-stage biopharmaceutical company, announced its presentations for upcoming April conferences. At the AACR Annual Meeting 2022 in New Orleans, Dr. Lawrence Lamb will discuss γδ T cell-based therapy for gliomas on April 11, and Dr. Lei Ding will address drug-resistant immunotherapy on April 13. Additionally, CEO William Ho will participate in a panel at the BIO Alabama Annual Conference 2022 on April 25.
IN8bio specializes in developing gamma-delta T cell therapies for tumors and is currently running Phase 1 trials for INB-200 and INB-100.
IN8bio, Inc. (Nasdaq: INAB) shared promising results from its ongoing Phase 1 trial of INB-100 for treating patients with high-risk acute myeloid leukemia (AML). All three patients treated showed durable remissions lasting 23.3, 21.0, and 9.3 months post-bone marrow transplant (BMT). The immune systems of patients were effectively reconstituted at six months, with no serious treatment-related adverse events reported. This update was presented at the European Society for Blood and Marrow Transplantation (EBMT) 48th Annual Meeting, indicating potential for further clinical advancements.
IN8bio reported promising clinical results for INB-200 and INB-100, showing a well-tolerated safety profile and extended progression-free survival in glioblastoma and leukemia patients, respectively. The company raised $40 million through an IPO to fund development of its gamma-delta T cell therapies. Financially, it ended 2021 with $37 million in cash, up from $18 million in 2020. However, it also faced a net loss of $14.7 million for the year. As the company continues to advance its clinical programs, it plans to file an IND for INB-400 and present at several upcoming scientific conferences.
FAQ
What is the current stock price of In8Bio (INAB)?
What is the market cap of In8Bio (INAB)?
What is IN8Bio, Inc.'s primary focus?
What are gamma-delta T cells?
What are IN8Bio's key clinical programs?
How does IN8Bio differentiate itself from competitors?
What challenges does IN8Bio face?
What is the DeltEx platform?
What types of cancers does IN8Bio target?
What is INB-400?
What is the significance of INB-100?
What makes gamma-delta T cell therapies safer than CAR-T therapies?
