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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Bicycle Therapeutics (NASDAQ: BCYC) reported promising interim results from its Phase I trials for BT5528 and BT8009 targeting advanced cancers. BT5528 showed 100% tumor reduction in urothelial patients and an 80% disease control rate in ovarian cancer patients. A recommended Phase II dose of 6.5-8.5mg/m² every other week was established. In the BT8009 trial, 36% of urothelial patients had partial responses. Both drugs were well tolerated with no dose-limiting toxicities noted. Expansion cohorts for BT5528 are expected to start in 2022.
Bicycle Therapeutics (NASDAQ: BCYC) has announced that interim Phase I results from its Phase I/II trial of BT5528, a second-generation Bicycle® Toxin Conjugate targeting EphA2, will be presented at the AACR-NCI-EORTC Virtual International Conference on October 7-10, 2021. The plenary oral presentation will be conducted by Dr. Meredith McKean from the Sarah Cannon Research Institute. The company will also host a conference call on October 7, 2021, at 3:00 p.m. ET to discuss these results and updates from the BT8009 program.
Bicycle Therapeutics plc (NASDAQ: BCYC) announced its participation in several investor conferences throughout September 2021. Key events include the Goldman Sachs Eleventh Annual Biotech Symposium on September 7, a pre-recorded presentation at H.C. Wainwright's Global Investment Conference on September 13, the Morgan Stanley Global Healthcare Conference on September 14, and the Cantor Virtual Global Healthcare Conference on September 27. Live webcasts of these events will be available on Bicycle's website, with archived replays accessible for 30 days.
Bicycle Therapeutics plc (NASDAQ: BCYC) reported second-quarter financial results for 2021, highlighting significant clinical progress and corporate updates. The company received $45 million from a licensing agreement with Ionis Pharmaceuticals for developing targeted oligonucleotide therapeutics and has strengthened its balance sheet with $14.4 million raised from its ATM offering. Cash reserves stood at $198.7 million as of June 30, expected to finance clinical milestones into 2024. However, the company reported a net loss of $17.9 million, or $(0.74) per share, an increase from a $12.1 million loss in Q2 2020.
Bicycle Therapeutics (NASDAQ: BCYC) has announced an exclusive licensing agreement with Ionis Pharmaceuticals for the use of its proprietary Bicycle® technology in delivering oligonucleotide therapeutics targeting the transferrin receptor (TfR1). Bicycle will receive $45 million upfront, including an $11 million equity investment, and is eligible for further milestone payments and royalties. This collaboration aims to leverage the selective delivery capabilities of Bicycles for precision medicines across various therapeutic areas, including skeletal and cardiac muscle diseases.
Ionis Pharmaceuticals has entered an exclusive licensing agreement with Bicycle Therapeutics to enhance its LIgand Conjugated Antisense (LICA) medicines. The deal grants Ionis access to Bicycle's proprietary Bicycles, targeting transferrin receptor 1 to improve delivery of oligonucleotides. Ionis made a $45 million upfront payment, which includes a license fee and equity investment. This partnership aims to boost Ionis' drug discovery capabilities, potentially leading to better treatment options for patients.
Bicycle Therapeutics (NASDAQ: BCYC) provided an update regarding its 2021 Annual General Meeting (AGM) scheduled for June 28, 2021. Due to ongoing COVID-19 restrictions in the UK, shareholders will not be allowed to attend the AGM in person. Instead, they are encouraged to vote by proxy and appoint the Chairman as their proxy. The company is conducting Phase I/II clinical trials for its drug candidates, including BT5528 and BT8009, targeting specific tumor antigens. The AGM will take place at Bicycle's headquarters in Cambridge, UK, at 1:00 p.m. London time.
Bicycle Therapeutics plc (NASDAQ: BCYC) announced its participation in three virtual investor conferences in June 2021. The events include:
- Jefferies Virtual Healthcare Conference on June 3 at 11:00 a.m. ET
- Goldman Sachs 42nd Annual Global Healthcare Conference on June 8 at 8:00 a.m. ET
- JMP Securities Life Sciences Conference on June 17 at 12:00 p.m. ET
Investors can access live webcasts on the company’s website, with archives available for 30 days post-event. Bicycle focuses on developing its proprietary Bicycle® technology for treating underserved diseases.
Bicycle Therapeutics (NASDAQ: BCYC) announced its financial results for Q1 2021, reporting cash of $195.9 million, an increase from $136.0 million at the end of 2020. The company is advancing its Bicycle Toxin Conjugates and plans to enter the clinic with lead compound BT7480 later this year. Research & development expenses rose to $9.7 million with a net loss of $16.2 million for the quarter. Bicycle continues to strengthen its balance sheet through an ATM offering, raising $75 million since January 2021. The firm is optimistic about its clinical milestones through 2024.
Bicycle Therapeutics (NASDAQ: BCYC) has announced the virtual presentation of preclinical findings on BT7480, an innovative Nectin-4/CD137 tumor-targeted immune cell agonist (TICATM), at the AACR Annual Meeting on April 10-15, 2021. The company will also showcase additional data on TICAs and Bicycle Toxin Conjugates (BTCs) through various sessions and e-posters. BT7480 is expected to enter clinical trials in H2 2021, highlighting Bicycle's commitment to advancing its immuno-oncology pipeline.
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