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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Bicycle Therapeutics (NASDAQ: BCYC) reported its fourth-quarter and full-year 2020 financial results, highlighting significant advancements despite COVID-19 challenges. The company has progressed multiple Bicycle Toxin Conjugates (BTCs) and is preparing for the clinical start of its first tumor-targeted immune cell agonist (TICA). Financially, Bicycle ended 2020 with $136 million in cash, up from $92 million in 2019, driven by successful fundraising efforts. However, the company reported a net loss of $51 million for 2020, with increased expenses in research and development and general administration.
Bicycle Therapeutics (NASDAQ:BCYC) announced the publication of preclinical studies on its innovative synthetic tumor-targeted immune cell agonists (TICAs) in the Journal for ImmunoTherapy of Cancer. The research highlights the potential of TICAs to enhance anticancer immunity through the modulation of CD137. Findings demonstrated that TICAs could efficiently co-stimulate human immune cells and eliminate tumors in preclinical models. The company plans to initiate a clinical trial for its lead TICA, BT7480, within the year, showcasing its commitment to advancing cancer immunotherapy.
Bicycle Therapeutics plc (NASDAQ: BCYC) reported notable advancements in its oncology pipeline, emphasizing its next-generation Bicycle Toxin Conjugates (BTCs) and tumor-targeted immune cell agonists (TICAs). Key programs include BT1718, which is in Phase IIa trials showing signs of anti-tumor activity, and BT5528, which has demonstrated preliminary efficacy in the ongoing Phase I trial. The company is also on track to expand its clinical trials for BT8009 and BT7480, with expectations for multiple clinical updates in 2021. Overall, Bicycle is positioning itself for significant milestones ahead.
Bicycle Therapeutics plc (NASDAQ: BCYC) announced its participation in the virtual 2020 Piper Sandler Healthcare Conference from December 1-3, 2020. The management will engage in a fireside chat on December 1 at 9:00 a.m. ET. Interested parties can access a recording in the Investors & Media section of Bicycle's website, which will be available for 90 days post-event. Bicycle Therapeutics is developing innovative therapeutics known as Bicycles, with ongoing clinical trials for its lead product candidate, BT1718, and others targeting various tumor antigens.
Bicycle Therapeutics (NASDAQ: BCYC) has entered into a settlement and license agreement with Pepscan Systems B.V. regarding the use of CLIPS peptide technology. The settlement resolves all intellectual property disputes and allows Bicycle to utilize this technology for product candidates BT1718 and THR-149. Bicycle will pay €3 million upfront, with an additional €1 million due on the first anniversary, plus potential milestone payments. This agreement is aimed at advancing Bicycle's clinical development efforts in the biopharmaceutical sector.
Bicycle Therapeutics plc (NASDAQ: BCYC) will participate in a fireside chat at the Jefferies Virtual London Healthcare Conference on November 19, 2020, at 1:10 p.m. ET. The chat will be available via a live webcast on Bicycle's website, with an archived replay accessible for 90 days post-event. Bicycle Therapeutics is advancing a new class of therapeutics called Bicycles that target underserved diseases. Their lead candidate, BT1718, is undergoing trials focusing on cancer treatment.
Bicycle Therapeutics (NASDAQ:BCYC) reported Q3 2020 financial results, highlighting advancements in its clinical pipeline despite COVID-19 challenges. Notable developments include the initiation of Phase IIa trials for BT1718 and BT8009, and a $50 million capital raise through an At-the-Market (ATM) offering. The company holds $149.8 million in cash as of September 30, 2020, up from $92.1 million at year-end 2019. However, it recorded a net loss of $10.1 million, slightly increasing from $9.5 million year-over-year. The company continues to expand its Scientific Advisory Board, enhancing its research capabilities.
Bicycle Therapeutics (NASDAQ: BCYC) announced the appointment of four prominent scientists to its Scientific Advisory Board, enhancing its capabilities in oncology and immunology. The new members include Drs. Garret FitzGerald, Jane Grogan, Caetano Reis e Sousa, and Charles Swanton. Their expertise is expected to guide the development of Bicycle’s innovative Bicycle-based therapeutics, which aim to establish new treatment paradigms for cancer. The company is currently advancing multiple clinical trials, including BT1718 and BT5528, targeting significant tumor antigens.
Bicycle Therapeutics (NASDAQ: BCYC) has successfully completed its at-the-market (ATM) offering, raising gross proceeds of $50 million. Additionally, the company secured a $40 million term loan from Hercules Capital, with $30 million available at closing. These financings enhance Bicycle's financial stability as it progresses multiple clinical programs, including its lead candidate BT7480, slated for initiation next year. The company aims to achieve key clinical milestones in 2021, leveraging approximately $120 million raised in 2020, over half of which was non-dilutive.
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