Welcome to our dedicated page for Biocryst Pharmaceuticals SEC filings (Ticker: BCRX), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) files a range of documents with the U.S. Securities and Exchange Commission that shed light on its operations as a biotechnology company focused on hereditary angioedema (HAE) and other rare diseases. On this page, you can review BioCryst’s SEC filings alongside AI-generated summaries that help explain complex disclosures in clear language.
Current Reports on Form 8-K are especially important for tracking material events at BioCryst. Recent 8-K filings describe key regulatory milestones, such as U.S. Food and Drug Administration approval of the New Drug Application for an oral pellet formulation of once-daily ORLADEYO® (berotralstat) for prophylactic therapy in pediatric HAE patients aged 2 to <12 years. Other 8-Ks cover quarterly financial results, preliminary revenue updates, and guidance for ORLADEYO net revenue, total revenue including RAPIVAB® (peramivir injection), and non-GAAP operating expenses.
Filings also document strategic transactions that shape BioCryst’s business model. One set of 8-Ks details the Stock Purchase Agreement and subsequent closing of the sale of BioCryst Ireland Limited, which held certain assets and rights related to the European ORLADEYO business, along with associated IP license, supply, brand support, transition services, and trademark license agreements. Another 8-K outlines the Agreement and Plan of Merger under which a BioCryst subsidiary will merge with Astria Therapeutics, Inc., including the cash-and-stock merger consideration, closing conditions, and potential delisting of Astria’s stock.
Governance and compensation developments also appear in BioCryst’s filings. Recent 8-Ks describe the planned retirement of the company’s President and Chief Executive Officer, the appointment of a new President and future CEO, the hiring of a new Chief Financial Officer, and related employment and separation agreements. Additional filings report inducement equity grants to new employees in accordance with Nasdaq Listing Rule 5635(c)(4).
Alongside these 8-Ks, investors can use this page to access BioCryst’s periodic reports on Forms 10-K and 10-Q (when available), which provide detailed discussions of risk factors, business strategy, and financial statements. Stock Titan’s AI tools highlight key sections of lengthy documents such as annual reports (10-K), quarterly reports (10-Q), and insider transaction filings (Form 4), helping you quickly understand revenue drivers, major agreements, executive changes, and other disclosures that may affect BCRX.
BioCryst Pharmaceuticals disclosure: The Vanguard Group filed an amendment to its Schedule 13G reporting 0 shares beneficially owned, representing 0% of Common Stock as of the amendment. The filing explains an internal realignment that disaggregated certain Vanguard subsidiaries' reporting of holdings.
BIOCRYST PHARMACEUTICALS INC director Theresa Heggie exercised stock options and sold shares on March 20, 2026. She exercised options for 49,933 shares of Common Stock at an exercise price of $6.30 per share and acquired the same number of shares.
She then sold 49,933 Common shares in an open-market transaction at a weighted average price of $10.11 per share, in multiple trades between $10.09 and $10.14. Following these transactions, she directly holds 65,352 shares of Common Stock.
BioCryst Pharmaceuticals Chief Legal Officer Alane P. Barnes exercised stock options and sold shares in a planned transaction. On March 16, 2026, she exercised options for 150,000 shares of common stock at an exercise price of $5.51 per share.
The same day, she sold 150,000 shares of common stock at a weighted average price of $9.15 per share, with individual sale prices ranging from $8.95 to $9.57. After these transactions, she directly owned 400,703 shares of common stock. The filing states the sale was made automatically under a pre-arranged Rule 10b5-1 trading plan adopted on August 13, 2025, indicating it was not a discretionary trade.
150,000 shares of Common Stock are listed for sale under Rule 144 in a Form 144 notice dated 03/16/2026. The filing shows an option grant date of 02/27/2017 and cash as the consideration method.
The document names Fidelity Brokerage Services LLC as broker and records a prior sale by Alane Barnes of 21,773 shares on 12/22/2025 for $166,563.45. The filing is a routine resale notice and does not state proceeds recipient beyond the broker listing.
BIOCRYST PHARMACEUTICALS INC director Jill C. Milne received additional company stock as part of her board compensation. On February 27, 2026, she acquired 528 shares of Common Stock at a price of $8.75 per share through a grant classified as a board retainer in stock rather than cash. After this award, she directly owns 15,382 Common Stock shares. A footnote explains the shares were issued in lieu of 100% of her prorated quarterly cash board member retainer of $4,625, meaning the company paid this portion of her board fees in stock instead of cash.
BIOCRYST PHARMACEUTICALS INC director Jon P. Stonehouse reported several equity transactions. On March 2, 2026, he exercised an employee stock option for 305,995 shares of common stock at an exercise price of $3.22 per share, converting the derivative into common stock.
That same day, he reported a disposition of 305,995 common shares at a weighted average price of $8.64 per share; a footnote states these shares were sold in multiple transactions between $8.54 and $8.81 under a pre-established Rule 10b5-1 trading plan, and the transaction occurred automatically. After this, his direct common stock holdings were 1,323,850 shares.
On February 27, 2026, he also acquired 421 common shares at $8.75 per share, issued in lieu of 50% of a prorated quarterly cash board retainer of $7,375. In addition, there are 40,000 common shares held indirectly in each of two irrevocable trusts, where his wife serves as co-trustee.
MILANO VINCENT reported acquisition or exercise transactions in this Form 4 filing.
BIOCRYST PHARMACEUTICALS INC director Vincent Milano received 848 shares of Common Stock as a compensation award. The shares were issued at a reference price of $8.75 per share, bringing his directly held total to 92,067 shares after the transaction.
The footnote explains that these shares were issued in lieu of 50% of his quarterly cash Board member retainer of $11,250 and, effective January 23, 2026, in lieu of 50% of the quarterly cash Board Chair retainer of $20,000. This represents routine equity-based director compensation rather than an open-market purchase or sale.
Frank Steven reported acquisition or exercise transactions in this Form 4 filing.
BIOCRYST PHARMACEUTICALS INC director Steven Frank received an equity grant of 1,285 shares of Common Stock on February 27, 2026. The shares were issued in lieu of 100% of his quarterly cash board member retainer of $11,250, reflecting a stock-based compensation choice rather than a market purchase. Following this award, he directly owns 18,903 shares of the company’s common stock.
McKee Amy E reported acquisition or exercise transactions in this Form 4 filing.
BIOCRYST PHARMACEUTICALS INC director Amy E. McKee reported receiving an award of 642 shares of common stock on February 27, 2026. The shares were issued in lieu of 50% of a quarterly cash board retainer of $11,250, bringing her direct holdings to 42,432 shares.