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Exicure, Inc., formerly known as Aurasense Therapeutics, is a pioneering biotechnology company that is redefining the landscape of immunomodulatory and gene silencing drugs. Leveraging its proprietary 3-dimensional Spherical Nucleic Acid (SNA™) architecture, Exicure is unlocking the therapeutic potential of nucleic acids across multiple organs. The company focuses on developing treatments targeting validated pathways for conditions ranging from inflammatory disorders to oncology.
Exicure's innovative SNA constructs are designed to overcome one of the most significant challenges in nucleic acid therapeutics: the efficient and safe delivery of therapeutic agents into cells and tissues. These constructs offer unparalleled transfection efficiency into various cell and tissue types, including skin, without the need for carriers or transfection agents. Additionally, SNA constructs hold promise as potent immunotherapeutic agents for addressing cancer and infectious diseases.
At the forefront of Exicure's pipeline are treatments for neurological disorders and hair loss, targeting ribonucleic acid (RNA) against validated disease targets. The company operates in a single segment focused on the discovery, research, and development of SNA-based treatments.
Recent milestones for Exicure include advancements in its lead programs, successful preclinical results, and strategic partnerships aimed at accelerating the development and commercialization of its groundbreaking therapies. These achievements underscore the company's commitment to transforming the future of medicine through cutting-edge nucleic acid technology.
The latest news and updates about Exicure, Inc. highlight the company's ongoing progress and significant developments in the biotechnology sector, providing valuable insights for investors and stakeholders.
Exicure, Inc. (NASDAQ: XCUR), a biotechnology company, announced its participation in key investor conferences for September 2021. The events include Citi’s 16th Annual Biopharma Conference from September 8-10, the H.C. Wainwright 23rd Annual Global Investment Conference with a presentation on September 13 at 7:00 AM ET, and the Baird Global Healthcare Conference on September 14 at 9:40 AM ET. The company is focused on developing therapeutics using its Spherical Nucleic Acid technology, with candidates targeting Friedreich’s ataxia and advanced solid tumors.
Exicure, Inc. (NASDAQ:XCUR) reported its financial results for Q2 2021, highlighting collaborations and advancements in its neurology pipeline. A $20 million upfront payment from Ipsen for Huntington’s disease and Angelman syndrome collaboration reinforces its financial stability, with potential for up to $1 billion in milestones. Research & Development expenses rose to $10.8 million, contributing to a net loss of $14.3 million. Despite increased losses, the company maintains sufficient liquidity, expecting to fund operations for at least 12 months due to existing cash and new partnership inflows.
Exicure, Inc. (NASDAQ: XCUR) has released an update on the Phase 1b/2 clinical trial of cavrotolimod (AST-008), targeting advanced solid tumors. Interim data shows that 26 patients have been dosed in the Phase 2 stage, with 17 evaluable patients. Notably, one patient with Merkel cell carcinoma (MCC) achieved a complete response, allowing for continued enrollment in the study. The overall response rate in evaluable MCC patients was 21%. The trial has seen a majority of treatment-related adverse events classified as mild, with two serious cases reported.
Exicure, a leader in gene regulatory therapeutics, has announced that CEO David Giljohann will present at the BTIG Virtual Biotechnology Conference on August 9, 2021, at 2:30 PM ET. During the event, Exicure will also host one-on-one investor meetings. The company is known for its Spherical Nucleic Acid technology and is developing treatments for various diseases, including neurology and immuno-oncology. Notably, Exicure is working on XCUR-FXN for Friedreich’s ataxia and cavrotolimod (AST-008) for advanced solid tumors.
Ipsen and Exicure Inc. have entered a collaboration to develop novel Spherical Nucleic Acids (SNAs) targeting Huntington’s disease and Angelman syndrome. Ipsen will pay Exicure $20 million upfront, with potential for up to $1 billion in milestone payments and royalties. SNAs are expected to enhance drug delivery to hard-to-reach areas like the brain. Both diseases currently lack approved disease-modifying therapies, presenting a significant market opportunity. The partnership aims to leverage Ipsen's expertise in neuroscience and Exicure's innovative delivery technology to address these unmet medical needs.
Exicure, Inc. (NASDAQ: XCUR) will host a virtual R&D Day on July 15, 2021, highlighting its neuroscience pipeline, particularly XCUR-FXN for Friedreich's Ataxia (FA). This program targets the disease's molecular cause and is on track for IND filing in late Q4 2021. The event will also cover advancements in therapies for SCN9A-related neuropathic pain and CLN3 Batten Disease. CEO Dr. David Giljohann emphasizes the potential of their SNA platform to address neurological disorders with promising data that may benefit patients.
Exicure, Inc. (NASDAQ: XCUR) announced that CEO David Giljohann will present at the Ladenburg Thalmann 2021 Healthcare Conference on July 13, 2021, from 1:00-1:25 PM in Track One. The panel discussion will be webcast, with replays available for 30 days on Exicure's website. The company focuses on gene regulatory and immunotherapeutic drugs utilizing its proprietary Spherical Nucleic Acid (SNA™) technology, aimed at treating neurological, immuno-oncologic, and inflammatory diseases. Exicure is developing XCUR-FXN for Friedreich’s ataxia and cavrotolimod for advanced solid tumors.
Exicure, Inc. (NASDAQ: XCUR) has announced CEO David Giljohann's participation in two upcoming conferences. The BIO Digital 2021 conference will feature a corporate update presentation on June 10, 2021, available for on-demand viewing. The BMO Biopharma Day will include a rare disease panel on June 22, 2021, streamed live at 10:30 AM ET. Exicure focuses on developing innovative therapeutics leveraging its Spherical Nucleic Acid technology, targeting conditions such as Friedreich’s ataxia and advanced solid tumors.
Exicure, Inc. (NASDAQ: XCUR) has appointed Brian C. Bock as its new Chief Financial Officer, effective immediately. Bock brings over 20 years of experience in life science investment banking and healthcare strategy, previously serving as Managing Director at Lincoln International. His expertise is expected to enhance Exicure’s business strategy and valuation. The company granted Bock an inducement stock option for 600,000 shares at an exercise price of $1.54, vesting over four years. Exicure focuses on developing therapies using its proprietary Spherical Nucleic Acid technology for various diseases.
Exicure, Inc. (NASDAQ: XCUR) reported Q1 2021 results, highlighting significant advancements in clinical programs and board expansion. The FDA granted Fast Track and Orphan Drug designations for cavrotolimod (AST-008) aimed at treating advanced Merkel cell carcinoma and squamous cell carcinoma. The company is on track to submit an IND for XCUR-FXN for Friedreich's Ataxia by year-end 2021. Financially, the company reported a net loss of $12.5 million, up from a $1.2 million net income year-over-year, while cash reserves decreased to $67.4 million.
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