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Exicure Inc - XCUR STOCK NEWS

Welcome to our dedicated page for Exicure news (Ticker: XCUR), a resource for investors and traders seeking the latest updates and insights on Exicure stock.

Overview

Exicure Inc is a biotechnology company committed to advancing the field of nucleic acid therapeutics. The company harnesses its proprietary Spherical Nucleic Acid (SNA) technology to develop novel immunomodulatory and gene silencing drugs. With an innovative 3-dimensional platform, Exicure addresses the historical challenge of delivering nucleic acids safely and effectively into cells and tissues, thereby opening new therapeutic avenues in inflammatory disorders, oncology, neurological conditions, and hair loss treatments. This comprehensive approach positions the company as a significant technical innovator within the biotechnology sector.

Innovative Technology

The cornerstone of Exicure's research and development is its advanced SNA architecture. Unlike traditional nucleic acid therapies that rely on carriers or transfection agents, the 3-dimensional, spherical structure of these constructs provides unparalleled transfection efficiency. This breakthrough allows for the targeted delivery of gene silencing molecules directly into diverse cell types, including those found in skin, thereby overcoming one of the major hurdles in therapeutic nucleic acid delivery.

Therapeutic Applications

Exicure's work is characterized by its focus on validated targets across multiple disease areas. The company is actively involved in the discovery and early research stages of treatments that not only modulate immune responses but also directly silence pathogenic genes. This dual approach is especially relevant in conditions where traditional treatment modalities have been limited or ineffective. Its SNA constructs have demonstrated potential across a range of applications, from mitigating inflammatory responses in chronic disorders to serving as potent immunotherapeutic agents in the battle against cancer and infectious diseases.

Research and Development Focus

Operating as a single-segment biotechnology firm, Exicure aggressively pursues a streamlined research and development process. The in-depth exploration of SNA technology enables the company to refine its treatment modalities and target multiple disease pathways simultaneously. The research efforts are centered on understanding the underlying mechanisms that govern nucleic acid interactions within cells, thus enhancing both safety and efficacy profiles. This scientific rigor underscores the company’s commitment to delivering innovative therapies built on a robust foundation of molecular biology and genomics.

Competitive Position and Market Significance

Within the competitive landscape of biotechnology, Exicure differentiates itself through its unique SNA technology that provides a carrier-free delivery mechanism, a feature often cited by experts as a significant breakthrough in gene therapy. While many competitors rely on conventional nucleic acid delivery methods, Exicure’s platform offers a strategic advantage by enhancing cellular uptake and ensuring more effective silencing of target genes. The company’s approach demonstrates a deep understanding of biological barriers and positions it as a key innovator capable of addressing a long-standing limitation in the field.

Strategic Value and Scientific Impact

The emphasis on safety, efficacy, and the versatile application of its technology speaks to the company’s broader strategic vision. By addressing a variety of therapeutic areas through a unified technological platform, Exicure not only streamlines its R&D efforts but also builds a foundation for potential cross-application benefits. This integrated strategy is bolstered by a commitment to rigorous scientific investigation, ensuring that each advancement in SNA technology is backed by detailed research data and clinical insight.

Conclusion

Exicure Inc stands at the intersection of molecular science and clinical innovation. With its focus on leveraging SNA technology to overcome the critical challenges of nucleic acid delivery, the company offers a promising platform for a range of therapeutic applications. Its research-driven model, which blends immunomodulatory strategies with effective gene silencing techniques, not only enhances the understanding of complex biological systems but also lays the groundwork for future biomedical advances. For investors and industry observers seeking a deep dive into the evolving landscape of advanced therapeutics, Exicure represents a compelling example of how targeted scientific innovation can reshape treatment paradigms.

  • Keywords: nucleic acid therapeutics, immunomodulatory therapies, gene silencing.
  • Core Focus: Development of innovative drug candidates through advanced SNA constructs.
  • Therapeutic Areas: Inflammatory disorders, oncology, neurological conditions, and hair loss.
  • Market Relevance: Pioneering carrier-free delivery systems that overcome traditional cellular uptake challenges.
Rhea-AI Summary

Exicure, Inc. (NASDAQ: XCUR) will host a virtual R&D Day on July 15, 2021, highlighting its neuroscience pipeline, particularly XCUR-FXN for Friedreich's Ataxia (FA). This program targets the disease's molecular cause and is on track for IND filing in late Q4 2021. The event will also cover advancements in therapies for SCN9A-related neuropathic pain and CLN3 Batten Disease. CEO Dr. David Giljohann emphasizes the potential of their SNA platform to address neurological disorders with promising data that may benefit patients.

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Exicure, Inc. (NASDAQ: XCUR) announced that CEO David Giljohann will present at the Ladenburg Thalmann 2021 Healthcare Conference on July 13, 2021, from 1:00-1:25 PM in Track One. The panel discussion will be webcast, with replays available for 30 days on Exicure's website. The company focuses on gene regulatory and immunotherapeutic drugs utilizing its proprietary Spherical Nucleic Acid (SNA™) technology, aimed at treating neurological, immuno-oncologic, and inflammatory diseases. Exicure is developing XCUR-FXN for Friedreich’s ataxia and cavrotolimod for advanced solid tumors.

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Exicure, Inc. (NASDAQ: XCUR) has announced CEO David Giljohann's participation in two upcoming conferences. The BIO Digital 2021 conference will feature a corporate update presentation on June 10, 2021, available for on-demand viewing. The BMO Biopharma Day will include a rare disease panel on June 22, 2021, streamed live at 10:30 AM ET. Exicure focuses on developing innovative therapeutics leveraging its Spherical Nucleic Acid technology, targeting conditions such as Friedreich’s ataxia and advanced solid tumors.

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Exicure, Inc. (NASDAQ: XCUR) has appointed Brian C. Bock as its new Chief Financial Officer, effective immediately. Bock brings over 20 years of experience in life science investment banking and healthcare strategy, previously serving as Managing Director at Lincoln International. His expertise is expected to enhance Exicure’s business strategy and valuation. The company granted Bock an inducement stock option for 600,000 shares at an exercise price of $1.54, vesting over four years. Exicure focuses on developing therapies using its proprietary Spherical Nucleic Acid technology for various diseases.

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Exicure, Inc. (NASDAQ: XCUR) reported Q1 2021 results, highlighting significant advancements in clinical programs and board expansion. The FDA granted Fast Track and Orphan Drug designations for cavrotolimod (AST-008) aimed at treating advanced Merkel cell carcinoma and squamous cell carcinoma. The company is on track to submit an IND for XCUR-FXN for Friedreich's Ataxia by year-end 2021. Financially, the company reported a net loss of $12.5 million, up from a $1.2 million net income year-over-year, while cash reserves decreased to $67.4 million.

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Exicure, Inc. (NASDAQ: XCUR) reported that Northwestern University researchers successfully utilized its gold-nanoparticle SNA technology in a first-in-human trial targeting glioblastoma (GBM). The phase 0 trial showed that intravenously administered siRNA-based SNAs can safely cross the blood-brain barrier and target the oncogene Bcl2L12. These findings, published in Science Translational Medicine, mark a significant milestone for Exicure’s technology in treating GBM. The company also plans to file an IND for Friedreich's ataxia by the end of 2021.

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Exicure, Inc. (NASDAQ:XCUR) reported impressive financial results for 2020, achieving $16.6 million in revenue, up from $1.3 million in 2019, primarily due to a collaboration with AbbVie. The net loss reduced to $24.7 million from $26.3 million year-over-year. Key advancements included the initiation of IND-enabling studies for XCUR-FXN targeting Friedreich’s ataxia and multiple FDA designations for cavrotolimod (AST-008), enhancing its oncology pipeline. Despite COVID-19 related delays, Exicure expects sufficient cash runway for the next 12 months to support ongoing trials.

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Exicure, Inc. (NASDAQ: XCUR) has announced the addition of Elizabeth Garofalo, M.D. and Andrew Sassine to its Board of Directors during a pivotal time for the company. The appointments are expected to enhance Exicure's development of its investigational drugs, cavrotolimod and XCUR-FXN. Garofalo brings over 25 years of clinical development experience, while Sassine contributes extensive financial expertise. Additionally, David Walt, Ph.D. will not seek re-election at the upcoming Annual Meeting. Exicure focuses on innovative therapies utilizing its proprietary Spherical Nucleic Acid technology.

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Exicure, Inc. (NASDAQ: XCUR) announced that the FDA has granted Orphan Drug Designation for its candidate cavrotolimod (AST-008) targeting Merkel cell carcinoma (MCC). This designation is a significant step towards addressing unmet medical needs for MCC patients. Exicure previously received Fast Track designations for cavrotolimod for MCC and cutaneous squamous cell carcinoma (CSCC). Cavrotolimod is currently in Phase 1b/2 clinical trials, showing promising anti-tumor activity with no serious adverse events reported thus far.

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Exicure, Inc. (Nasdaq: XCUR) announced that CEO David Giljohann will present at the 2021 H.C. Wainwright Global Life Sciences Conference on March 9-10, 2021. The presentation will be available for registered attendees to view on-demand starting March 9, 2021, at 7:00 AM EST, and it will be archived for 90 days. Exicure is a biotechnology firm focusing on gene regulatory therapies using its proprietary Spherical Nucleic Acid (SNA) technology, currently in preclinical development for Friedreich’s ataxia and advancing in clinical trials for solid tumors.

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FAQ

What is the current stock price of Exicure (XCUR)?

The current stock price of Exicure (XCUR) is $13 as of April 4, 2025.

What is the market cap of Exicure (XCUR)?

The market cap of Exicure (XCUR) is approximately 80.7M.

What is the core technology behind Exicure Inc?

Exicure Inc utilizes proprietary Spherical Nucleic Acid (SNA) technology, a 3-dimensional platform that enables carrier-free delivery of nucleic acid therapeutics into cells.

Which therapeutic areas does Exicure focus on?

The company primarily targets inflammatory disorders, oncology, neurological conditions, and hair loss through its innovative immunomodulatory and gene silencing approaches.

How does SNA technology differentiate Exicure from other biotech companies?

Unlike conventional methods that require carriers or transfection agents, Exicure's SNA constructs offer unparalleled cellular uptake and targeted gene silencing, addressing key challenges in nucleic acid delivery.

What is the business model of Exicure Inc?

Exicure operates as a focused research and development company, investing in the discovery and refinement of innovative nucleic acid therapies that may eventually be commercialized through licensing or partnerships.

How does Exicure Inc enhance the efficacy of its treatments?

The company leverages its unique SNA architecture to ensure efficient penetration and effective gene silencing across multiple cell and tissue types, thereby maximizing therapeutic potential.

Does Exicure Inc target only a single disease area?

No, Exicure's SNA-based platform provides versatility, enabling research into multiple therapeutic applications ranging from immune modulation in inflammatory diseases to targeted treatments in oncology and beyond.

What are the advantages of Exicure's approach in nucleic acid delivery?

The SNA technology eliminates the need for traditional transfection agents, offering improved safety profiles, higher transfection efficiency, and the potential for broader applicability across various medical conditions.

How does Exicure Inc position itself within the biotech industry?

Exicure Inc is recognized for its scientific innovation and strategic focus on overcoming the challenges of nucleic acid therapies, positioning itself as a key contributor to advanced therapeutic research without making prognostic claims.
Exicure Inc

Nasdaq:XCUR

XCUR Rankings

XCUR Stock Data

80.68M
1.54M
68.33%
11.2%
0.93%
Biotechnology
Pharmaceutical Preparations
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