Telo Genomics Highlights New MRD Methodology at The 2025 International Myeloma Society Meeting

Rhea-AI Summary

Telo Genomics (OTCQB: TDSGF) presented a groundbreaking poster abstract on minimal residual disease (MRD) at the 22nd International Myeloma Society Annual Meeting in Toronto. The presentation introduced a novel workflow combining Multiple Myeloma (MM) Circulating Tumor Cells (CTCs) enumeration with TeloView® 3D telomere profiling platform.

The innovative methodology offers a less invasive biomarker for Multiple Myeloma by analyzing peripheral blood instead of bone marrow. This approach provides functional and biologically actionable data beyond traditional enumeration methods, helping assess disease progression risk. The abstract will be published in the Clinical Lymphoma, Myeloma, & Leukemia Journal.

Toronto, Ontario--(Newsfile Corp. - September 19, 2025) - Telo Genomics Corp. (TSXV: TELO) (OTCQB: TDSGF) (the "Company" or "Telo"), a leader in the development of diagnostic and prognostic tests for human disease through the analysis of telomeres, today announced that the company has presented a poster abstract on minimal residual disease ("MRD") during the 22nd International Myeloma Society Annual Meeting in Toronto, Canada.

The abstract, titled "3D Telomere Profiling of MRD in Liquid Biopsy as a Predictive Marker of Disease Stability or Progression", was presented at the meeting by Dr. Yulia Shifrin, Laboratory Director of Telo Genomics. The abstract will be published as a special supplement to the Clinical Lymphoma, Myeloma, & Leukemia Journal and made available on the Company website.

The poster presentation describes a new workflow for MRD evaluation that combines the enumeration and immunophenotyping of individual Multiple Myeloma (MM) Circulating Tumor Cells (CTCs), with the TeloView^® 3D telomere profiling platform. The evaluation of CTCs from peripheral blood, rather than bone marrow, offers a less invasive biomarker for MM that allows for continuous monitoring of patients. Unlike conventional approaches, this approach yields functional and biologically actionable data on disease cells, providing insights on risk of disease progression beyond simple enumeration.

The International Myeloma Society (IMS) is a global professional organization dedicated to advancing the science and treatment of multiple myeloma. Its 22nd Annual Meeting is taking place from September 17-20, 2025. IMS meetings are widely considered as a defining annual forum in the myeloma field.

About Telo Genomics
Telo Genomics is a biotech company pioneering the most comprehensive telomere platform in the industry with powerful applications and prognostic solutions. These include liquid biopsies and related technologies in oncology and neurological diseases. Liquid biopsy is a rapidly growing field of significant interest to the medical community for being less invasive and more easily replicated than traditional diagnostic approaches. By combining our team's considerable expertise in quantitative analysis of 3D telomeres with molecular biology and artificial intelligence to recognize disease associated genetic instability, Telo Genomics is developing simple and accurate products that improve day-to-day care for patients by serving the needs of pathologists, clinicians, academic researchers and drug developers. The benefits of our proprietary technology have been substantiated in 160+ peer reviewed publications and in 30+ clinical studies involving more than 3,000 patients with multiple cancers and Alzheimer's disease. Our lead application, Telo-MM is being developed to provide important, actionable information to medical professionals in the treatment of Multiple Myeloma, a deadly form of blood cancer. For more information, please visit www.telodx.com.

About MRD Assessment
MRD is defined as the small number of cancer cells that remain in the body after treatment, stratifying MRD cells as in remission or active provides important actionable information for clinicians. Also, the FDA's Oncologic Drugs Advisory Committee (ODAC) voted unanimously in April 2024 to accept MRD as a clinical endpoint for accelerated approval of new multiple myeloma therapies, paving the way for faster drug approvals. Minimal residual disease (MRD) testing is emerging as an important tool in assessing treatment response and guiding therapeutic decisions in oncology. With advancements in drug development technologies, and a growing emphasis on personalized healthcare, the MRD testing industry is expected to exhibit substantial global expansion in the coming years. The MRD global testing market size is expected to reach USD 4.1 billion by 2032 (Globe Newswire - August 14, 2023).

About Multiple Myeloma
Multiple Myeloma is a challenging and potentially deadly blood cancer that involves plasma cells, a type of blood cell that helps to fight infection. It is the second most common blood cancer with an incidence of 35,000 new cases every year in the US, and ~180,000 patients receive treatment at any given time. The introduction of next-generation therapies (including targeted treatments) has increased the median survival rate to over 5 years, but MM is still considered incurable. Two asymptomatic precursors, Monoclonal Gammopathy of Unknown Significance ("MGUS") and SMM generally precede the progression to classic symptomatic MM. While MGUS carries a steady risk of progression of 1% per year, SMM is more heterogenous with nearly 40% of patients progressing in the first 5 years, 15% in the next 5 years, reaching the same low risk as MGUS after 10 years. To date, identifying patients who will more rapidly progress to MM remains an important clinical need. MM treatment includes various combinations of drugs with a cost as high as $150,000 per year per patient. As most patients will develop resistance to treatment and relapse within a median of 2 years, identifying them proactively remains another important clinical need. Notably, the total addressable market for both MM assays is over 750,000 tests per year in the US.

For further information, please contact:
Brett Maas
Managing Partner
(646) 536-7331
Brett@HaydenIR.com
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Scottsdale, AZ 85260
haydenir.com

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Cautionary Note Regarding Forward-Looking Statements
Certain information contained herein may constitute "forward-looking information" under Canadian securities legislation. Generally, forward-looking information can be identified by the use of forward-looking terminology such as "will", or variations of such words and phrases or statements that certain actions, events or results "will" occur. Certain forward-looking statements, including statements regarding the Company's receipt of TSXV acceptance of the stock option grant are based on the Company's estimates and are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information, including capital expenditures and other costs. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. The Company will not update any forward-looking statements or forward-looking information that are incorporated by reference herein, except as required by applicable securities laws.

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FAQ

What new technology did Telo Genomics (TDSGF) present at the 2025 IMS Meeting?

Telo Genomics presented a new MRD workflow that combines Multiple Myeloma Circulating Tumor Cells enumeration with TeloView® 3D telomere profiling platform, offering less invasive monitoring through peripheral blood analysis.

How does Telo Genomics' new MRD methodology differ from conventional approaches?

Unlike conventional approaches, it analyzes peripheral blood instead of bone marrow, providing less invasive monitoring and delivers functional and biologically actionable data on disease cells beyond simple enumeration.

When and where was Telo Genomics' MRD research presented?

The research was presented at the 22nd International Myeloma Society Annual Meeting in Toronto, Canada, taking place from September 17-20, 2025.

Where will Telo Genomics' MRD research be published?

The abstract will be published as a special supplement to the Clinical Lymphoma, Myeloma, & Leukemia Journal and will be available on the Company's website.