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Protara Therapeutics Inc - TARA STOCK NEWS

Welcome to our dedicated page for Protara Therapeutics news (Ticker: TARA), a resource for investors and traders seeking the latest updates and insights on Protara Therapeutics stock.

Overview

Protara Therapeutics Inc (TARA) is a clinical-stage biotechnology company committed to identifying and advancing transformative therapies for cancer and rare diseases. Leveraging robust expertise in cell therapy and investigational drug development, the company designs innovative treatments to address significant unmet medical needs. Its research-driven approach underscores a solid commitment to improving the quality of life for patients who have limited therapeutic options.

Clinical Development Programs

Protara Therapeutics operates with a dual-focus platform in its clinical pipeline:

  • TARA-002: An investigational cell-based therapy harnessed as an immunopotentiator, TARA-002 is under clinical evaluation for the treatment of conditions such as lymphatic malformations. Drawing from the historical data of similar immunomodulatory approaches, it has demonstrated potential in eliciting favorable clinical responses in challenging patient populations.
  • IV Choline Chloride: This investigational therapy represents a novel phospholipid substrate replacement intended for patients reliant on parenteral support. It is designed to address choline deficiency—a critical factor in liver function maintenance—particularly for those unable to derive sufficient choline through oral or enteral nutrition.

Therapeutic Focus and Research Areas

The company’s portfolio underscores its emphasis on:

  • Rare Diseases: Addressing conditions that often lack sufficient treatment alternatives, with therapies that target complex biological pathways and metabolic deficiencies.
  • Cancer Treatment: Advancing cell-based immunotherapy as part of its broader strategy to explore innovative treatment modalities for oncology patients.

This focus leverages strong industry keywords such as cell therapy, investigational drug development, and transformative therapies to establish a distinct presence in the biotech sector.

Pipeline and Scientific Innovation

Protara Therapeutics' research and clinical development build on rigorous scientific rationale. Its lead candidate, TARA-002, incorporates cell-based technology that has evolved from previous immunomodulatory treatments. In parallel, the development of IV Choline Chloride is driven by clinical evidence underscoring the prevalence of choline deficiency in parenteral support patients, alongside the associated risks of liver injury and other systemic impairments.

Regulatory Achievements and Market Position

In addition to its robust clinical pipeline, Protara has secured important regulatory designations that validate its therapeutic approaches. Achievements include FDA orphan drug designation for its IV Choline Chloride product, which reinforces the product's potential to meet an unmet clinical need. The company’s transparent clinical trial conduct and engagement with the FDA reflect its adherence to high regulatory standards and its commitment to patient safety.

Industry Context and Competitive Landscape

Operating in a highly competitive and research-intensive biotechnology sector, Protara Therapeutics is distinguished by its targeted focus on diseases with significant therapeutic gaps. The company’s approach integrates cutting-edge cell therapy and metabolic replacement strategies, differentiating it from other entities that may concentrate on more common therapeutic areas. Its strategic positioning is underscored by methodical clinical trial designs, comprehensive data evaluations, and engagements with regulatory bodies that collectively contribute to a nuanced understanding of its competitive advantages.

Scientific Rationale and Innovation

Every therapeutic candidate in Protara’s pipeline is based on a solid scientific foundation. The cell-based therapy TARA-002 builds on established immunopotentiating mechanisms, while the development of IV Choline Chloride addresses critical biochemical needs essential for liver health and systemic function. This focus on scientific innovation, combined with detailed preclinical and clinical research, underscores the company’s commitment to evidence-based medicine and its potential to impact patient care in underexplored therapeutic areas.

Commitment to Addressing Unmet Needs

Protara Therapeutics has developed a clear value proposition: to deliver breakthrough therapies where conventional treatments have fallen short. The company is keenly focused on rare pediatric and oncology cases where the need for alternative and effective treatments is most pronounced. Its strategy is not only based on developing novel therapeutics but also on filling critical gaps in clinical practice—demonstrated by initiatives to bring the first FDA-approved IV choline formulation to the parenteral support patient community.

Operational Excellence and Future Research Infrastructure

Beyond its clinical candidates, Protara Therapeutics emphasizes operational rigor and scientific integrity. Its multi-phase clinical trials are designed to address the intricacies of immunotherapy and metabolism replacement, thereby setting benchmarks for safety and efficacy within the clinical-stage biotechnology industry. The company's disciplined approach to trial design, patient safety monitoring, and regulatory compliance evidences its commitment to high operational standards and a robust research infrastructure.

Conclusion

In summary, Protara Therapeutics Inc. stands as a comprehensive model of clinical-stage biotechnology innovation. With a focus on transformative cell-based therapies and investigational metabolic replacement strategies, the company provides an important platform for addressing significant and underserved medical needs. By integrating rigorous clinical research with transparent operational practices and regulatory achievements, Protara Therapeutics has established itself as a key participant in the niche market of advanced therapies for rare diseases and cancer, offering an informative case study for industry observers and potential research collaborators alike.

Rhea-AI Summary

Protara Therapeutics, Inc. (Nasdaq: TARA) will present at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on September 22, 2021, at 12:25 PM ET. The presentation will be accessible through a webcast on the Company's website and archived for 90 days post-event. Protara focuses on developing transformative therapies for cancer and rare diseases, including its lead program TARA-002 for non-muscle invasive bladder cancer and IV Choline Chloride for intestinal failure-associated liver disease.

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Protara Therapeutics (TARA) announced a study revealing that approximately 30% of patients dependent on parenteral nutrition (PN) experience cholestasis, a key pathology of intestinal failure-associated liver disease (IFALD). This highlights an unmet medical need for effective treatments. The company is developing IV Choline Chloride as a replacement therapy for choline deficiency in PN patients, with promising results from prior studies. Protara's ongoing research aims to further investigate IFALD and assess the prevalence of choline deficiency among affected patients.

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Protara Therapeutics, Inc. (Nasdaq: TARA) announced its participation in the H.C. Wainwright 23rd Annual Global Investment Conference, occurring virtually from September 13-15, 2021. The company's prerecorded presentation will be available on September 13, 2021, at 7:00am ET, accessible via the Events and Presentations section on their website. Protara focuses on developing therapies for cancer and rare diseases, including TARA-002 for bladder cancer and lymphatic malformations, as well as IV Choline Chloride for intestinal failure-associated liver disease.

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Protara Therapeutics, Inc. (TARA) reported significant progress in developing TARA-002 for non-muscle invasive bladder cancer (NMIBC) and lymphatic malformations (LMs). As of June 30, 2021, the company holds $145 million in cash and investments. They completed IND-enabling studies and are on track to submit an IND application by year-end, aiming to initiate a Phase 1 trial for NMIBC. However, R&D expenses rose to $5.9 million, contributing to a net loss of $12.8 million for Q2 2021, compared to a $7.1 million loss in Q2 2020.

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Protara Therapeutics (Nasdaq: TARA) announced management will present at the Ladenburg Thalmann Healthcare Conference on July 14, 2021, at 10:00am ET. This virtual event will allow participants to gain insights into Protara's pipeline, including TARA-002, a cell-based therapy aimed at treating non-muscle invasive bladder cancer and lymphatic malformations.

The presentation will be available via webcast on the company's website, archived for 90 days for investor access.

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Protara Therapeutics (Nasdaq: TARA) welcomed Dr. Jane Huang to its Board of Directors, bringing extensive experience in oncology drug development. Dr. Huang's leadership roles include Chief Medical Officer at BeiGene and key positions at Acerta Pharma and Genentech. The appointment aims to enhance Protara's progress in developing TARA-002, a therapy for non-muscle invasive bladder cancer and lymphatic malformations. This move is expected to strengthen Protara's strategic direction as they continue to advance their innovative therapies for cancer and rare diseases.

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Protara Therapeutics (Nasdaq: TARA) has announced its participation in two significant virtual investor conferences. The first is the Oppenheimer Rare & Orphan Disease Summit on May 21, 2021, at 11:35 AM ET, followed by the Jefferies Virtual Healthcare Conference on June 2, 2021, at 1:30 PM ET. Investors can access live webcasts of the presentations on the Company's website, which will be archived for 90 days. Protara focuses on developing therapies for cancer and rare diseases, including its lead program, TARA-002.

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Protara Therapeutics (TARA) provided a business update and financial results for Q1 2021, highlighting strong cash reserves of $155 million as of March 31, 2021. The company is on track to file an Investigational New Drug (IND) application and initiate a Phase 1 trial for TARA-002 targeting non-muscle invasive bladder cancer (NMIBC) by year-end 2021. The research and development expenses rose 125% to $7 million due to costs related to TARA-002, while general administrative expenses decreased. Protara reported a net loss of $13.5 million or $1.20 per share.

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Protara Therapeutics (Nasdaq: TARA) announced plans for an additional clinical study to support their Biologics License Application for TARA-002, targeting Lymphatic Malformations (LMs). Based on FDA feedback, the company will conduct large-scale GMP manufacturing comparability in late 2021 and initiate a pediatric clinical study pending alignment with the FDA. TARA-002 is derived from the same cell bank as OK-432, an approved treatment in Japan and Taiwan. Protara aims to deliver the first FDA-approved drug for LMs.

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Protara Therapeutics (Nasdaq: TARA) has granted inducement non-qualified stock options for 120,000 shares to Dr. Martín Sebastian Olivo, the new Chief Medical Officer. The options have an exercise price of $15.30 per share, aligning with Protara's closing price as of April 19, 2021. Vesting occurs over four years, with 25% vesting after one year and the remainder vesting monthly. This award, approved by the Compensation Committee, aligns with NASDAQ Listing Rule 5635(c)(4). Protara is focused on developing therapies for cancer and rare diseases.

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FAQ

What is the current stock price of Protara Therapeutics (TARA)?

The current stock price of Protara Therapeutics (TARA) is $4.01 as of April 1, 2025.

What is the market cap of Protara Therapeutics (TARA)?

The market cap of Protara Therapeutics (TARA) is approximately 149.6M.

What is the primary focus of Protara Therapeutics Inc?

Protara Therapeutics is dedicated to advancing transformative therapies for cancer and rare diseases through innovative cell-based and metabolic replacement programs. Its research focuses on filling unmet clinical needs where conventional treatments are limited.

How does Protara generate value in the biotech sector?

The company focuses on clinical development to advance novel therapeutic candidates, including a cell-based therapy and an IV phospholipid substrate replacement therapy. Its approach integrates rigorous clinical trials and regulatory milestones to address specific patient populations.

What is TARA-002 and which conditions does it target?

TARA-002 is an investigational cell-based therapy designed as an immunopotentiator, with clinical evaluations underway for conditions such as lymphatic malformations and certain oncology indications. It builds on past data from similar therapeutic approaches to address rare and difficult-to-treat diseases.

What distinguishes IV Choline Chloride in Protara's portfolio?

IV Choline Chloride is an innovative, investigational therapy aimed at addressing choline deficiency in patients on parenteral support. It targets metabolic deficiencies that contribute to liver injury, offering a potential solution where oral or enteral supplementation is inadequate.

How does Protara address unmet medical needs?

Protara targets areas with significant treatment gaps, particularly in rare diseases and oncology. Its therapeutic candidates focus on conditions where limited treatment options exist, emphasizing the need for breakthrough interventions in severely underserved patient populations.

What regulatory achievements have validated Protara’s approach?

The company has secured critical regulatory designations, including orphan drug status and Fast Track designation for its IV Choline Chloride therapy. These achievements underscore both the scientific rationale behind its products and the recognized potential to meet essential clinical needs.

How are Protara's clinical trials structured?

Protara conducts multi-phase, rigorously designed clinical trials to evaluate safety, efficacy, and dosing of its investigational therapies. The trial structures often include observational studies, registrational trials, and patient safety lead-ins that ensure robust data collection and regulatory compliance.

How does Protara differentiate itself from other biotech companies?

Protara differentiates itself through focused innovation in both cell therapy and metabolic support solutions, targeting niche patient communities with significant unmet needs. Its commitment to data-driven research and strategic regulatory engagements further reinforces its unique position in the competitive biotech landscape.
Protara Therapeutics Inc

Nasdaq:TARA

TARA Rankings

TARA Stock Data

149.64M
35.44M
3.48%
86.65%
8.08%
Biotechnology
Biological Products, (no Disgnostic Substances)
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United States
NEW YORK