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Sensei Biotherapeutics, Inc. - SNSE STOCK NEWS

Welcome to our dedicated page for Sensei Biotherapeutics news (Ticker: SNSE), a resource for investors and traders seeking the latest updates and insights on Sensei Biotherapeutics stock.

Overview

Sensei Biotherapeutics, Inc. is a clinical stage biotechnology company at the forefront of immuno-oncology. With a focus on next-generation cancer therapeutics, the company harnesses the power of its proprietary conditionally active antibody platform to selectively activate immune responses within the acidic tumor microenvironment. By leveraging subtle antigenic differences between normal and cancerous tissues, Sensei aims to overcome the limitations of conventional immunotherapies.

TMAb Platform & Technology

The cornerstone of Sensei’s approach is the TMAb™ (Tumor Microenvironment Activated Biologics) platform. This innovative technology is designed to function only under the specific conditions found in tumor tissues, such as low pH, ensuring that the therapeutic effect is localized to cancerous regions. This selective activation minimizes off-target effects and has the potential to mitigate common safety challenges, thus offering a precise method to disable immunosuppressive signals while activating T-cell responses.

Clinical Development & Research Focus

Sensei Biotherapeutics is advancing multiple investigational product candidates in the clinical arena. The company’s lead candidate is a conditionally active antibody that targets immune checkpoints, specifically focusing on the VISTA pathway—a critical mediator of T-cell suppression in cancer. Through its rigorous clinical trials, Sensei is evaluating the safety, tolerability, pharmacokinetics, and efficacy of these biologics, both as monotherapy and in combination with other immunotherapeutic agents. This clinical strategy not only reflects a deep understanding of tumor biology but also highlights the company’s commitment to addressing the unmet needs of patients with advanced solid tumors.

Scientific Rationale & Market Positioning

The innovative approach employed by Sensei is grounded in the fundamental principles of immune recognition and activation. The company leverages its expertise in immuno-oncology to design therapies that operate under the unique environmental conditions of tumors, thereby overcoming the inherent challenges of distinguishing self from non-self in cancer. This scientific rigor positions Sensei as an important participant in the evolving landscape of cancer therapeutics, where conditionally active agents are increasingly recognized for their potential to achieve effective and safe treatment outcomes.

Competitive Landscape & Industry Impact

In an industry characterized by rapid innovation and rigorous research standards, Sensei Biotherapeutics distinguishes itself through its focused technology and strategic clinical development. By integrating insights from academic collaborations and employing a technology that directly addresses the challenges of immune evasion, the company situates itself uniquely among its peers. Its conditionally active therapeutic candidates provide a nuanced approach that contrasts with more traditional immunotherapeutic modalities, emphasizing both safety and efficacy in treatment-resistant cancers.

Conclusion

Sensei Biotherapeutics, Inc. exemplifies a dedicated effort to revolutionize cancer treatment through targeted immuno-oncology solutions. With its state-of-the-art TMAb platform and a clear focus on overcoming the challenges associated with immune suppression in the tumor microenvironment, the company offers a detailed case study in combining scientific innovation with practical clinical strategies. Investors and industry observers alike will find that Sensei’s approach—steeped in technical precision and robust clinical foundations—provides a comprehensive understanding of the potential and complexities inherent in modern cancer therapeutics.

Rhea-AI Summary

Sensei Biotherapeutics (Nasdaq: SNSE) has entered a clinical supply agreement with Regeneron for its anti-PD1 therapy Libtayo® (cemiplimab) to support a Phase 1/2 trial evaluating SNS-101, a VISTA-blocking antibody. The trial, aimed at solid tumors, will begin in 2023, pending regulatory approval. Sensei plans to submit an Investigational New Drug application by April 2023. This collaboration aims to explore the potential of SNS-101 combined with PD-1 inhibition, leveraging preclinical data suggesting strong anti-tumor activity.

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eSensei Biotherapeutics (Nasdaq: SNSE) announces the closure of its Boston research site, resulting in a 40% workforce reduction, aimed at decreasing operating expenses. This strategic move is expected to extend the company's cash runway into the second half of 2025. The IND submission for their lead antibody, SNS-101, is anticipated by April 2023. The company will maintain its Rockville, Maryland facility to support ongoing programs, including SNS-101, designed to target the immune checkpoint VISTA.

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Sensei Biotherapeutics (NASDAQ: SNSE) announced that CEO John Celebi will participate in a fireside chat at the Piper Sandler 34th Annual Healthcare Conference on December 1, 2022, at 2:00 p.m. ET in New York. The event will focus on the company's innovative therapeutics for cancer, specifically the TMAb™ platform, which aims to activate immune responses in the tumor microenvironment. A webcast of the presentation will be available on their website, with a replay accessible for 90 days post-event.

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Sensei Biotherapeutics (Nasdaq: SNSE) has presented promising preclinical data for its antibody candidate SNS-101 at the Society for Immunotherapy of Cancer annual meeting. This highly pH-selective antibody targets VISTA, showing significant anti-tumor effects and favorable pharmacokinetics. Additionally, the company is advancing its SNS-102 program, focusing on VSIG4, with plans for an IND filing for SNS-101 in the first half of 2023. Both programs leverage Sensei’s TMAb™ platform aimed at improving cancer therapies.

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Sensei Biotherapeutics (Nasdaq: SNSE) reported third-quarter results for 2022, showing a net loss of $13.4 million, up from $9.7 million a year earlier. The company's cash position was $116.6 million, expected to fund operations into Q1 2025. Sensei highlighted favorable preclinical data for SNS-101, which demonstrated a superior cytokine release profile and advanced anti-tumor effects. Upcoming events include a virtual KOL webinar on November 21 and presentations at the SITC Annual Meeting.

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Sensei Biotherapeutics (NASDAQ: SNSE) announced a KOL webinar titled “Lessons from VISTA: New Strategies to Address an Important Immune Checkpoint,” scheduled for November 21, 2022, at 2:15 p.m. ET. Featuring Dr. Robert Schreiber, the webinar will cover VISTA's role in immuno-oncology and present data on SNS-101, a VISTA-blocking antibody designed for the low pH tumor microenvironment. Participants can register online, and a recording will be available afterward. The event will conclude with a Fireside Chat with Dr. Schreiber and a live Q&A session.

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Sensei Biotherapeutics, Inc. (NASDAQ: SNSE) will present at the 13th Annual Jefferies Global Healthcare Conference in London on November 17, 2022, at 7:25 a.m. GMT. The presentation, led by CEO John Celebi, will highlight the company's focus on developing innovative immuno-oncology therapeutics, particularly through its TMAb™ platform. The lead candidate, SNS-101, targets the VISTA checkpoint in the tumor microenvironment to enhance T cell activation against tumors. A webcast of the presentation will be available on Sensei’s website for approximately 90 days.

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Sensei Biotherapeutics (Nasdaq: SNSE) has announced its participation in the SITC 37th Annual Meeting in Boston from November 8-12, 2022. The company will present two posters highlighting their advancements in immuno-oncology. The first presentation will focus on novel T-cell receptors related to the VSIG4 macrophage receptor, while the second will discuss SNS-101, an antibody that enhances anti-PD-1 sensitivity in tumors. These advancements underscore Sensei's commitment to developing innovative cancer therapeutics using their TMAb and ImmunoPhage platforms.

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Sensei Biotherapeutics (NASDAQ: SNSE) presented promising data on SNS-101, a monoclonal antibody targeting the immune checkpoint VISTA, at the Sixth Annual CRI-ENCI-AACR International Cancer Immunotherapy Conference. Preclinical results indicate SNS-101 enhances anti-tumor effects when combined with anti-PD-1 antibodies, achieving five complete responses in a resistant tumor model. The antibody also exhibits a favorable pharmacokinetic profile, reducing the risk of cytokine release syndrome compared to traditional VISTA antibodies. This data may support SNS-101's potential for broad oncological applications.

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Sensei Biotherapeutics (Nasdaq: SNSE) announced it will present new preclinical data on SNS-101, a monoclonal antibody targeting the immune checkpoint VISTA, at the Sixth Annual CRI-ENCI-AACR International Cancer Immunotherapy Conference in New York from September 28 to October 1, 2022. The poster presentation is scheduled for September 30, highlighting SNS-101's favorable pharmacokinetic properties and its potential to enhance anti-PD-1 responses. This aligns with Sensei's mission of developing next-generation cancer therapeutics.

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FAQ

What is the current stock price of Sensei Biotherapeutics (SNSE)?

The current stock price of Sensei Biotherapeutics (SNSE) is $0.345 as of April 1, 2025.

What is the market cap of Sensei Biotherapeutics (SNSE)?

The market cap of Sensei Biotherapeutics (SNSE) is approximately 8.7M.

What is the core focus of Sensei Biotherapeutics?

Sensei Biotherapeutics is focused on developing next-generation immuno-oncology therapeutics using conditionally active antibodies that target cancer within the tumor microenvironment.

How does the TMAb platform work?

The TMAb platform is engineered to activate selectively under the acidic conditions found in the tumor microenvironment, which helps to minimize off-target effects and enhance precise T-cell activation.

What makes Sensei's approach unique in the immuno-oncology field?

Sensei’s approach is unique because it employs conditionally active antibodies that leverage environmental cues in tumors to selectively disrupt immune suppression, thereby overcoming common challenges in cancer immunotherapy.

Which immune checkpoints are targeted by Sensei’s therapeutics?

The company targets checkpoints such as VISTA, a molecule known for its role in suppressing T-cell activity, particularly within the harsh conditions of the tumor microenvironment.

What development stage is Sensei Biotherapeutics in?

Sensei is a clinical stage company with several investigational products under clinical evaluation, demonstrating its commitment to advancing novel immuno-oncology treatments.

How does targeted activation in the tumor microenvironment benefit patients?

By activating the therapeutic antibodies only where the tumor conditions exist, Sensei’s technology aims to reduce systemic side effects and enhance the specificity and safety of cancer treatments.

How does Sensei differentiate itself from other companies?

Sensei differentiates itself through its proprietary, conditionally active antibody platform that specifically exploits the low pH environment of tumors, addressing both safety and efficacy challenges seen in traditional immunotherapies.

What types of cancers are targeted by Sensei’s therapeutic candidates?

Sensei’s clinical programs primarily target advanced solid tumors, including cancers that are traditionally resistant to standard immunotherapy, by focusing on the tumor microenvironment.
Sensei Biotherapeutics, Inc.

Nasdaq:SNSE

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8.65M
16.60M
34.22%
9.37%
0.58%
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