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Sensei Biotherapeutics, Inc. (Nasdaq: SNSE) is a clinical stage immuno-oncology company, renowned for its innovation in next-generation cancer immunotherapies. Headquartered in Gaithersburg, MD, Sensei leverages its proprietary TMAb™ (Tumor Microenvironment Activated biologics) platform to develop cutting-edge therapeutics designed to harness the body's immune system against cancer. The company’s leading product candidates include SNS-101, SNS-102, SNS-103, and SNS-201, all of which are conditionally active antibodies targeting different immunosuppressive markers within the tumor microenvironment.
Sensei’s flagship candidate, SNS-101, is designed to block the VISTA (V-domain Ig suppressor of T cell activation) checkpoint selectively within the low pH tumor microenvironment, where VISTA acts as a suppressor of T cells by binding the receptor PSGL-1. SNS-101 is currently undergoing a multi-center Phase 1/2 clinical trial, evaluating its safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy as both a monotherapy and in combination with Regeneron's PD-1 inhibitor, Libtayo® (cemiplimab), in patients with advanced solid tumors. Initial data are promising, showing SNS-101 to be well-tolerated and demonstrating clinical activity, particularly in tumor types typically resistant to PD-1 monotherapy.
Other promising candidates include SNS-102, targeting VSIG-4 (V-Set and Immunoglobulin Domain Containing 4), and SNS-103, targeting CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1), as well as SNS-201, a conditionally active VISTAxCD28 bispecific antibody. The company has established key academic collaborations, including with Brown University, to bolster its research and development efforts.
Financially, Sensei maintains a strong balance sheet with cash reserves projected to fund operations into the second half of 2025. Recent financial updates show reduced R&D and G&A expenses due to strategic restructuring, leading to a narrower net loss. The company is focused on advancing its clinical trials, with expected milestones including initial combination safety and pharmacokinetic data for SNS-101 in early 2024, followed by topline monotherapy data later in the year.
For more information, visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.
Sensei Biotherapeutics (Nasdaq: SNSE) has presented promising preclinical data for its antibody candidate SNS-101 at the Society for Immunotherapy of Cancer annual meeting. This highly pH-selective antibody targets VISTA, showing significant anti-tumor effects and favorable pharmacokinetics. Additionally, the company is advancing its SNS-102 program, focusing on VSIG4, with plans for an IND filing for SNS-101 in the first half of 2023. Both programs leverage Sensei’s TMAb™ platform aimed at improving cancer therapies.
Sensei Biotherapeutics (Nasdaq: SNSE) reported third-quarter results for 2022, showing a net loss of $13.4 million, up from $9.7 million a year earlier. The company's cash position was $116.6 million, expected to fund operations into Q1 2025. Sensei highlighted favorable preclinical data for SNS-101, which demonstrated a superior cytokine release profile and advanced anti-tumor effects. Upcoming events include a virtual KOL webinar on November 21 and presentations at the SITC Annual Meeting.
Sensei Biotherapeutics (NASDAQ: SNSE) announced a KOL webinar titled “Lessons from VISTA: New Strategies to Address an Important Immune Checkpoint,” scheduled for November 21, 2022, at 2:15 p.m. ET. Featuring Dr. Robert Schreiber, the webinar will cover VISTA's role in immuno-oncology and present data on SNS-101, a VISTA-blocking antibody designed for the low pH tumor microenvironment. Participants can register online, and a recording will be available afterward. The event will conclude with a Fireside Chat with Dr. Schreiber and a live Q&A session.
Sensei Biotherapeutics, Inc. (NASDAQ: SNSE) will present at the 13th Annual Jefferies Global Healthcare Conference in London on November 17, 2022, at 7:25 a.m. GMT. The presentation, led by CEO John Celebi, will highlight the company's focus on developing innovative immuno-oncology therapeutics, particularly through its TMAb™ platform. The lead candidate, SNS-101, targets the VISTA checkpoint in the tumor microenvironment to enhance T cell activation against tumors. A webcast of the presentation will be available on Sensei’s website for approximately 90 days.
Sensei Biotherapeutics (Nasdaq: SNSE) has announced its participation in the SITC 37th Annual Meeting in Boston from November 8-12, 2022. The company will present two posters highlighting their advancements in immuno-oncology. The first presentation will focus on novel T-cell receptors related to the VSIG4 macrophage receptor, while the second will discuss SNS-101, an antibody that enhances anti-PD-1 sensitivity in tumors. These advancements underscore Sensei's commitment to developing innovative cancer therapeutics using their TMAb and ImmunoPhage platforms.
Sensei Biotherapeutics (NASDAQ: SNSE) presented promising data on SNS-101, a monoclonal antibody targeting the immune checkpoint VISTA, at the Sixth Annual CRI-ENCI-AACR International Cancer Immunotherapy Conference. Preclinical results indicate SNS-101 enhances anti-tumor effects when combined with anti-PD-1 antibodies, achieving five complete responses in a resistant tumor model. The antibody also exhibits a favorable pharmacokinetic profile, reducing the risk of cytokine release syndrome compared to traditional VISTA antibodies. This data may support SNS-101's potential for broad oncological applications.
Sensei Biotherapeutics (Nasdaq: SNSE) announced it will present new preclinical data on SNS-101, a monoclonal antibody targeting the immune checkpoint VISTA, at the Sixth Annual CRI-ENCI-AACR International Cancer Immunotherapy Conference in New York from September 28 to October 1, 2022. The poster presentation is scheduled for September 30, highlighting SNS-101's favorable pharmacokinetic properties and its potential to enhance anti-PD-1 responses. This aligns with Sensei's mission of developing next-generation cancer therapeutics.
Sensei Biotherapeutics (NASDAQ: SNSE) announced preliminary preclinical data for SNS-101, an antibody targeting the VISTA immune checkpoint. Results indicate that SNS-101 effectively overcomes pharmacokinetic challenges and enhances anti-tumor effects when combined with anti-PD-1 antibodies. Additionally, SNS-101 shows a favorable pharmacokinetic profile, with a median half-life of approximately three weeks. Ongoing IND-enabling studies aim to evaluate SNS-101's potential for treatment in solid cancers, with an IND filing planned for the first half of 2023.
Sensei Biotherapeutics (NASDAQ: SNSE) announced its participation in two key investor conferences in September 2022, aimed at exploring the latest in immuno-oncology developments.
The conferences are:
- Citi’s 17th Annual Biopharma Conference (September 7-8, Boston, MA)
- Wells Fargo’s 2022 Healthcare Conference (September 7-9, Boston, MA)
Interested portfolio managers and analysts can arrange meetings with company management through their respective representatives.
Sensei Biotherapeutics (NASDAQ: SNSE) announced progress in its clinical programs, including pre-IND feedback from the FDA for SNS-101, an anti-VISTA antibody, expected to file an IND in the first half of 2023. The company will present new pharmacokinetic data in non-human primates in Q3 2022. The strong financial position, with cash equivalents of $123.7 million, supports operations through Q1 2025. Research and development expenses increased to $6.4 million due to higher headcount and inflation. The net loss was reported at $10.5 million for Q2 2022.
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