Sensei Biotherapeutics to Present New Preclinical Data for SNS-103, a Conditionally Active Monoclonal Antibody Targeting ENTPDase1 (CD39), at the American Association for Cancer Research (AACR) Annual Meeting 2023

Rhea-AI Summary

Sensei Biotherapeutics (NASDAQ: SNSE) will unveil new preclinical data on SNS-103, a monoclonal antibody targeting CD39, at the AACR Annual Meeting 2023 in Orlando from April 14-19, 2023. The presentation titled 'Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment' is scheduled for April 18, 2023, from 1:30 PM to 5:00 PM ET.

Sensei aims to develop therapeutics that activate immune responses against tumors utilizing its TMAb™ platform, and SNS-103 is part of its ongoing research in immune-oncology.

Positive

• Presentation of new preclinical data on SNS-103 at a major cancer conference.
• Focus on a promising therapeutic area targeting CD39.
• Potential to enhance T cell activity against tumors.

Negative

• None.

BOSTON, March 14, 2023 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), an immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients, will present new preclinical data on SNS-103, a conditionally active, monoclonal antibody targeting ENTPDase1 (ecto-nucleoside triphosphate diphosphohydrolase-1, also known as CD39) at the American Association for Cancer Research (AACR) Annual Meeting 2023, being held April 14-19, 2023 in Orlando, FL.

Presentation Details:

Title: Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment
Presentation Type: Poster
Session Category: Tumor Biology
Session Title: Inflammation and Tumor Progression
Date and time: Tuesday, April 18, 2023 1:30 PM - 5:00 p.m. ET
Location: Poster Section 5

The abstract will be available online on the AACR Online Program Planner. The poster will be made available on the Sensei Bio website following the presentation.

About Sensei Biotherapeutics
Sensei Biotherapeutics (NASDAQ: SNSE) is an immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients. Through its TMAb™ (Tumor Microenvironment Activated biologics) platform, Sensei develops conditionally active therapeutics designed to disable checkpoints and other immunosuppressive signals selectively in the tumor microenvironment to unleash T cells against tumors. Sensei’s lead investigational candidate is SNS-101, a conditionally active antibody designed to block the V-domain Ig suppressor of T cell activation (VISTA) checkpoint selectively within the low pH tumor microenvironment, where VISTA acts as a suppressor of T cells by binding the receptor PSGL-1. The company is also developing SNS-102, a conditional binding monoclonal antibody targeting V-Set and Immunoglobulin Domain Containing 4 (VSIG-4), as well as SNS-103, also a conditionally active monoclonal antibody targeting ecto-nucleoside triphosphate diphosphohydrolase-1 (ENTPDase1), also known as CD39. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

Cautionary Note Regarding Forward-Looking Statements
Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words and phrases such as “believe”, “designed to,” “expect”, “may”, “plan”, “potential”, “will”, and similar expressions, and are based on Sensei’s current beliefs and expectations. These forward-looking statements include expectations regarding the development of Sensei’s product candidates and platforms; the potential safety profile of Sensei’s product candidates; the potential benefits of Sensei’s product candidates; and the expected release of new preclinical data for SNS-103. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the development of therapeutic product candidates, such as the risk that any one or more of Sensei’s product candidates will not be successfully developed or commercialized; the risk of delay or cessation of any planned clinical trials of Sensei’s product candidates; the risk that prior results, such as signals of safety, activity or durability of effect, observed from preclinical studies will not be replicated or will not continue in ongoing or future studies or clinical trials involving Sensei’s product candidates; the risk that Sensei’s product candidates or procedures in connection with the administration thereof will not have the safety or efficacy profile that we anticipate; risks associated with Sensei’s dependence on third-party suppliers and manufacturers, including sole source suppliers, over which Sensei may not always have full control; risks regarding the accuracy of Sensei’s estimates of expenses, capital requirements and needs for additional financing; and other risks and uncertainties that are described in Sensei’s Annual Report on Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) on November 8, 2022 and Sensei’s other Periodic Reports filed with the SEC. Any forward-looking statements speak only as of the date of this press release and are based on information available to Sensei as of the date of this release, and Sensei assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

Investor Contact:
Michael Biega
Senior Director, Investor Relations
Sensei Biotherapeutics
mbiega@senseibio.com

Media Contact:
Chris Railey
Ten Bridge Communications
chris@tenbridgecommunications.com 

FAQ

What is SNS-103 and its significance for SNSE?

SNS-103 is a monoclonal antibody targeting CD39, which is intended to improve immune response in tumor environments.

When will the data on SNS-103 be presented?

The data will be presented on April 18, 2023, during the AACR Annual Meeting.

What is the focus of the presentation at the AACR Annual Meeting?

The presentation focuses on conditionally active antibodies that block CD39 activity in acidic tumor microenvironments.

How might the research impact SNSE's market position?

Positive outcomes from the research could enhance SNSE's reputation in immuno-oncology and attract investor interest.