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About Sensei Biotherapeutics, Inc.
Sensei Biotherapeutics, Inc. (Nasdaq: SNSE) is a clinical-stage biotechnology company specializing in the development of next-generation immuno-oncology therapeutics aimed at transforming cancer treatment. Headquartered in Gaithersburg, Maryland, the company leverages its proprietary TMAb™ (Tumor Microenvironment Activated Biologics) platform to create conditionally active biologics that selectively target the unique conditions of the tumor microenvironment. These therapeutics are designed to either disable immunosuppressive signals or activate immunostimulatory signals, thereby enhancing the immune system's ability to detect and eliminate cancer cells.
Proprietary Technology Platform
At the core of Sensei Biotherapeutics’ innovation is its TMAb™ platform, which addresses the complexities of immune recognition in cancer. Unlike traditional approaches, TMAb™ therapeutics are conditionally active, meaning they are specifically designed to function within the acidic pH and immunosuppressive conditions of the tumor microenvironment. This targeted approach minimizes off-target effects, improves safety profiles, and enhances therapeutic efficacy. The platform exemplifies cutting-edge advancements in immuno-oncology by focusing on overcoming the challenges of tumor immune evasion and resistance to existing therapies.
Product Pipeline
Sensei Biotherapeutics is advancing a robust pipeline of investigational therapeutics, each targeting critical pathways in cancer immunotherapy:
- SNS-101: A conditionally active monoclonal antibody targeting VISTA (V-domain Ig suppressor of T cell activation), a checkpoint protein implicated in immune suppression within the tumor microenvironment. SNS-101 is designed to block VISTA selectively under low pH conditions, enabling T-cell activation and mitigating safety issues seen in earlier VISTA-targeting approaches.
- SNS-102: A monoclonal antibody targeting VSIG-4 (V-Set and Immunoglobulin Domain Containing 4), another immune checkpoint protein associated with tumor immune evasion.
- SNS-103: A monoclonal antibody targeting CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1), which plays a role in suppressing anti-tumor immune responses by generating immunosuppressive adenosine in the tumor microenvironment.
- SNS-201: A bispecific antibody combining a CD28 agonist arm with a pH-sensitive anti-VISTA arm, designed to simultaneously activate T cells and block immune suppression within tumors.
Market Position and Industry Significance
Sensei Biotherapeutics operates within the highly competitive and rapidly evolving immuno-oncology market. The company’s focus on conditionally active biologics targeting the tumor microenvironment distinguishes it from competitors, addressing unmet needs in cancer treatment. By targeting previously undruggable pathways like VISTA, Sensei aims to expand the therapeutic landscape for patients with advanced solid tumors, including those resistant to existing immunotherapies.
Challenges and Opportunities
Developing innovative cancer therapies involves navigating significant challenges, including regulatory approvals, manufacturing complexities, and competition from other biotech firms. However, Sensei’s proprietary TMAb™ platform and its emphasis on safety and efficacy provide a competitive edge. The company’s ability to address the limitations of first-generation checkpoint inhibitors positions it as a key player in the immuno-oncology space.
Collaborations and Research
Sensei Biotherapeutics collaborates with leading academic institutions and industry partners to advance its research and development efforts. These partnerships enhance the company’s ability to innovate and validate its therapeutic candidates through rigorous preclinical and clinical studies.
Conclusion
Sensei Biotherapeutics, Inc. exemplifies innovation in the field of cancer immunotherapy. Through its TMAb™ platform and a focused pipeline of conditionally active biologics, the company is addressing critical challenges in oncology. By targeting the unique conditions of the tumor microenvironment, Sensei is poised to make significant contributions to the advancement of cancer treatment, offering hope to patients with limited therapeutic options.
Sensei Biotherapeutics announced the FDA's clearance of its IND application for SNS-101, a VISTA-blocking antibody, enabling a Phase 1/2 clinical trial for patients with solid tumors. This key milestone is expected to significantly impact cancer treatment. The trial will assess SNS-101's safety, tolerability, pharmacokinetics, and efficacy, both alone and combined with Regeneron’s Libtayo® (cemiplimab). The initial patient dosing is anticipated in mid-2023. Preclinical data suggest SNS-101's promising potential to inhibit tumor growth and enhance PD-1 blockade effects, while maintaining better pharmacokinetics and reducing cytokine release syndrome risk.
Sensei Biotherapeutics (Nasdaq: SNSE) presented new preclinical data on its SNS-103 program at the AACR Annual Meeting 2023, focusing on targeting CD39, an enzyme linked to an immunosuppressive tumor microenvironment. The data suggests that SNS-103, a conditionally active monoclonal antibody, selectively binds to CD39 in low pH conditions typical of tumors, potentially improving anti-tumor immunity by preserving extracellular ATP and inhibiting adenosine generation.
The poster presentation highlighted the selection of 8 antibodies for further optimization from a panel of 83, with a lead product candidate expected to be selected in 2023. This advancement could position Sensei favorably within the immuno-oncology sector.
Sensei Biotherapeutics (Nasdaq: SNSE) announced its participation in a panel discussion titled ‘Overcoming Resistance & Immunosuppression in Solid Tumors’ at the Canaccord Genuity Horizons in Oncology Virtual Conference on April 20, 2023, at 3:00 p.m. ET. The company specializes in developing next-generation therapeutics for cancer patients through its TMAb™ platform.
Sensei's lead candidate is SNS-101, designed to inhibit T cell suppression in the tumor microenvironment. The company is also advancing SNS-102, targeting VSIG-4, and SNS-103, which targets ENTPDase1, also known as CD39. For more information, visit www.senseibio.com.
BOSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics (Nasdaq: SNSE), an immuno-oncology firm, announced that its CEO, John Celebi, will participate in a panel on 'Novel Approaches in Immunotherapy' at the Cantor Fitzgerald's Future of Oncology Virtual Symposium on April 3rd at 10:00 a.m. ET.
Sensei Biotherapeutics focuses on developing next-generation therapeutics for cancer patients using its TMAb™ platform. The lead candidate is SNS-101, targeting VISTA in the tumor microenvironment. Other candidates include SNS-102 and SNS-103, which target VSIG-4 and ENTPDase1, respectively. For more details, visit www.senseibio.com.
Sensei Biotherapeutics (Nasdaq: SNSE) announced the submission of an Investigational New Drug (IND) application for its lead candidate, SNS-101, aimed at treating solid tumors through VISTA blockade. The company has formed partnerships with Regeneron, the National Cancer Institute, and Washington University to bolster development. Sensei expects to advance a second TMAb™ program to IND-enabling studies. The company reported a cash position of $107.1 million and projects a runway into the second half of 2025. However, the net loss increased to $48.6 million in 2022, up from $36.8 million in 2021.
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