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Sensei Biotherapeutics, Inc. (Nasdaq: SNSE) is a clinical stage immuno-oncology company, renowned for its innovation in next-generation cancer immunotherapies. Headquartered in Gaithersburg, MD, Sensei leverages its proprietary TMAb™ (Tumor Microenvironment Activated biologics) platform to develop cutting-edge therapeutics designed to harness the body's immune system against cancer. The company’s leading product candidates include SNS-101, SNS-102, SNS-103, and SNS-201, all of which are conditionally active antibodies targeting different immunosuppressive markers within the tumor microenvironment.
Sensei’s flagship candidate, SNS-101, is designed to block the VISTA (V-domain Ig suppressor of T cell activation) checkpoint selectively within the low pH tumor microenvironment, where VISTA acts as a suppressor of T cells by binding the receptor PSGL-1. SNS-101 is currently undergoing a multi-center Phase 1/2 clinical trial, evaluating its safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy as both a monotherapy and in combination with Regeneron's PD-1 inhibitor, Libtayo® (cemiplimab), in patients with advanced solid tumors. Initial data are promising, showing SNS-101 to be well-tolerated and demonstrating clinical activity, particularly in tumor types typically resistant to PD-1 monotherapy.
Other promising candidates include SNS-102, targeting VSIG-4 (V-Set and Immunoglobulin Domain Containing 4), and SNS-103, targeting CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1), as well as SNS-201, a conditionally active VISTAxCD28 bispecific antibody. The company has established key academic collaborations, including with Brown University, to bolster its research and development efforts.
Financially, Sensei maintains a strong balance sheet with cash reserves projected to fund operations into the second half of 2025. Recent financial updates show reduced R&D and G&A expenses due to strategic restructuring, leading to a narrower net loss. The company is focused on advancing its clinical trials, with expected milestones including initial combination safety and pharmacokinetic data for SNS-101 in early 2024, followed by topline monotherapy data later in the year.
For more information, visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.
Sensei Biotherapeutics announced the FDA's clearance of its IND application for SNS-101, a VISTA-blocking antibody, enabling a Phase 1/2 clinical trial for patients with solid tumors. This key milestone is expected to significantly impact cancer treatment. The trial will assess SNS-101's safety, tolerability, pharmacokinetics, and efficacy, both alone and combined with Regeneron’s Libtayo® (cemiplimab). The initial patient dosing is anticipated in mid-2023. Preclinical data suggest SNS-101's promising potential to inhibit tumor growth and enhance PD-1 blockade effects, while maintaining better pharmacokinetics and reducing cytokine release syndrome risk.
Sensei Biotherapeutics (Nasdaq: SNSE) presented new preclinical data on its SNS-103 program at the AACR Annual Meeting 2023, focusing on targeting CD39, an enzyme linked to an immunosuppressive tumor microenvironment. The data suggests that SNS-103, a conditionally active monoclonal antibody, selectively binds to CD39 in low pH conditions typical of tumors, potentially improving anti-tumor immunity by preserving extracellular ATP and inhibiting adenosine generation.
The poster presentation highlighted the selection of 8 antibodies for further optimization from a panel of 83, with a lead product candidate expected to be selected in 2023. This advancement could position Sensei favorably within the immuno-oncology sector.
Sensei Biotherapeutics (Nasdaq: SNSE) announced its participation in a panel discussion titled ‘Overcoming Resistance & Immunosuppression in Solid Tumors’ at the Canaccord Genuity Horizons in Oncology Virtual Conference on April 20, 2023, at 3:00 p.m. ET. The company specializes in developing next-generation therapeutics for cancer patients through its TMAb™ platform.
Sensei's lead candidate is SNS-101, designed to inhibit T cell suppression in the tumor microenvironment. The company is also advancing SNS-102, targeting VSIG-4, and SNS-103, which targets ENTPDase1, also known as CD39. For more information, visit www.senseibio.com.
BOSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics (Nasdaq: SNSE), an immuno-oncology firm, announced that its CEO, John Celebi, will participate in a panel on 'Novel Approaches in Immunotherapy' at the Cantor Fitzgerald's Future of Oncology Virtual Symposium on April 3rd at 10:00 a.m. ET.
Sensei Biotherapeutics focuses on developing next-generation therapeutics for cancer patients using its TMAb™ platform. The lead candidate is SNS-101, targeting VISTA in the tumor microenvironment. Other candidates include SNS-102 and SNS-103, which target VSIG-4 and ENTPDase1, respectively. For more details, visit www.senseibio.com.
Sensei Biotherapeutics (Nasdaq: SNSE) announced the submission of an Investigational New Drug (IND) application for its lead candidate, SNS-101, aimed at treating solid tumors through VISTA blockade. The company has formed partnerships with Regeneron, the National Cancer Institute, and Washington University to bolster development. Sensei expects to advance a second TMAb™ program to IND-enabling studies. The company reported a cash position of $107.1 million and projects a runway into the second half of 2025. However, the net loss increased to $48.6 million in 2022, up from $36.8 million in 2021.
Sensei Biotherapeutics (NASDAQ: SNSE) announced on March 21, 2023, the submission of an Investigational New Drug (IND) application to the FDA for SNS-101, a VISTA-blocking antibody targeting solid tumors. This therapy is designed to selectively inhibit the VISTA checkpoint, which suppresses T cell activity, potentially enhancing anti-tumor responses. Preclinical data indicate SNS-101's efficacy as a monotherapy and in combination with PD-1 blockade, while minimizing poor pharmacokinetics and cytokine release syndrome risks. Sensei aims to address solid cancers with this innovative therapeutic approach.
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