Welcome to our dedicated page for Phio Pharmaceuticals news (Ticker: PHIO), a resource for investors and traders seeking the latest updates and insights on Phio Pharmaceuticals stock.
About Phio Pharmaceuticals Corp
Phio Pharmaceuticals Corp (NASDAQ: PHIO) is a clinical-stage biotechnology company that is reshaping the landscape of cancer treatment through its proprietary INTASYL siRNA gene silencing technology. As a company focused on immuno-oncology therapeutics, Phio is dedicated to improving the ability of the body’s immune cells to target and eliminate tumor cells. Backed by rigorous scientific research and collaborative partnerships with leading research institutions, the company is committed to advancing next-generation treatments that address the immune suppression often induced by tumors.
Core Technology and Therapeutic Approach
The cornerstone of Phio Pharmaceuticals’ approach is its INTASYL platform, a unique self-delivering RNAi technology that bypasses the conventional need for specialized drug delivery systems. Unlike other RNAi therapies, INTASYL can target virtually any gene with high specificity, ensuring that immune cells are better equipped to kill cancer cells without impacting non-harmful cells. This innovative technology is specifically designed to silence genes responsible for tumor-induced immune suppression, thereby enhancing the efficacy of adoptive cell therapy as well as other immuno-oncology treatments.
Clinical-Stage Programs and Product Pipeline
Phio’s product development strategy centers on a portfolio of therapeutics that leverage INTASYL to selectively silence key checkpoint proteins. Its lead clinical program, PH-762, is an INTASYL compound aimed at silencing PD-1, a protein that inhibits the immune response by dampening T cell activity. This approach offers a potential non-surgical treatment option for various skin cancers such as cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma. In addition, the company is developing other compounds, including ones that target TIGIT and PD-L1, to broaden its impact in the immuno-oncology space.
The ongoing Phase 1b clinical trials utilize an intratumoral injection strategy, which not only provides localized treatment but also enhances the immune system's ability to combat tumors systemically. The safety and efficacy profiles observed in early cohorts underscore the potential of Phio’s approach, with early clinical data emphasizing tumor clearance in patients while maintaining a manageable safety profile.
Scientific Collaborations and Research Excellence
Phio Pharmaceuticals collaborates with renowned institutions across the globe, including partnerships with collaborative research centers and academic institutions. These collaborations, with entities like Gustave Roussy, Medigene AG, and Helmholtz Zentrum, underscore the company’s commitment to scientific excellence and innovation. Working jointly with experts in immunology and oncology, Phio benefits from access to advanced research methodologies and clinical expertise, further solidifying its position as an innovator in the RNAi and immuno-oncology domains.
Market Position and Competitive Landscape
Operating within the competitive realm of biotechnology and cancer therapeutics, Phio Pharmaceuticals distinguishes itself by leveraging a novel technology platform that integrates precision medicine with the power of the immune system. The ability of the INTASYL platform to effectively silence genes without the need for extensive formulation upgrades positions the company uniquely amongst peers and potential collaborators. This technological edge is particularly significant in the context of adoptive cell therapy, where streamlined delivery and strong gene specificity are critical for success.
Technological Advantages of INTASYL
The INTASYL siRNA technology offers several key advantages:
- Self-Delivery: Eliminates the need for complex delivery vehicles, reducing development hurdles and potential complications.
- High Specificity: Capable of silencing target genes with a high degree of precision across a wide range of cell types, thereby mitigating off-target effects.
- Versatility: The platform’s ability to target virtually any gene affords tremendous flexibility in addressing various pathways associated with tumor immune suppression.
- Enhanced Immune Function: By targeting immunosuppressive proteins, Phio’s therapies aim to activate and bolster the body's natural defenses against cancer cells.
Understanding the Business Model
Phio Pharmaceuticals generates value by advancing its clinical-stage pipeline through strategic investments in research and development, clinical trials, and collaborations with academic and research centers. While the company is primarily in the research and development phase, its focus on breakthrough technologies and innovative therapeutic approaches forms the backbone of its long-term strategy. By maintaining a diversified pipeline that targets multiple immune regulatory pathways, Phio effectively manages scientific risk while paving the way for potential future therapies that address the multifaceted challenges of cancer treatment.
Commitment to Scientific Rigor and Transparency
In its quest to provide a thorough understanding of its technologies and clinical developments, Phio Pharmaceuticals embraces a transparent approach to research and data reporting. The company regularly presents data at industry conferences and in peer-reviewed journals, thereby contributing to the broader scientific community’s understanding of RNAi and immuno-oncology. This commitment to transparency not only enhances its credibility among investors and researchers but also underscores the company’s dedication to advancing scientific knowledge in a challenging and dynamic field.
Conclusion
Phio Pharmaceuticals Corp stands at the intersection of innovation and clinical research, leveraging a unique self-delivering RNAi technology to address the unmet needs in cancer therapy. Its comprehensive approach, which combines precision gene silencing with enhanced immune cell activity, positions it as a notable participant in the biotechnology arena. By continuously advancing its clinical programs and forging strategic collaborations, Phio demonstrates a firm commitment to improving patient outcomes through cutting-edge science and technology.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO), a clinical stage biotechnology company, has announced its participation in the Renmark Financial Communications Virtual Non-Deal Roadshow Series. The company's CEO and Chairman of the Board, Robert Bitterman, will present on Wednesday, October 9, 2024, at 2 PM EDT.
Phio Pharmaceuticals specializes in INTASYL® siRNA gene silencing technology, designed to enhance the effectiveness of immune cells in killing tumor cells. Stakeholders, investors, and interested individuals are invited to attend this live virtual event.
To participate, attendees should register through the provided link and use the latest version of Google Chrome for optimal connectivity. A replay of the event will be available on the Renmark Financial Communications website.
Phio Pharmaceuticals (NASDAQ: PHIO) announced its upcoming presentation at the American Society of Gene & Cell Therapy's 2024 Advancing Gene + Cell Therapies for Cancer conference. The event will be held virtually and in Philadelphia on October 16-17, 2024.
The presentation will focus on Phio's INTASYL compound PH-894, which targets BRD4 to enhance Natural Killer (NK) cell-based immunotherapy. Specifically, PH-894 silences BRD4 and enhances activation and proliferation of NK cells for Adoptive Cell Therapy (ACT).
Presentation details:
- Title: INTASYL PH-894: Targeting BRD4 to Enhance NK Cell-Based Immunotherapy
- Presenter: Melissa Maxwell
- Date: October 16, 2024
- Time: 8 a.m. - 6:45 p.m. ET
- Location: FDR Ballroom, Wyndham Hotel, Philadelphia Historic District
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) announced it will present data on its INTASYL technology platform at the 20th Annual Oligonucleotide Therapeutics Society (OTS) Meeting in Montreal from October 6th-9th. The presentation, titled 'INTASYL Self-Delivering RNAi: a Flexible Platform for Cancer Treatment', will focus on how INTASYL can enhance ex vivo expansion processes to improve functionality and outcomes of adoptive cell therapies like NK, TIL, or CAR-T.
INTASYL's advantage lies in its simplified chemical composition, designed to reduce toxicity and improve tolerability and efficacy in therapeutic development. The poster presentation (Number P180) will be given by Melissa Maxwell on October 8th from 3:45-6:45 PM at the Centre Mont-Royal in Montreal.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical stage biotechnology company, has announced its participation in the Renmark Financial Communications Virtual Non-Deal Roadshow Series. The event is scheduled for Tuesday, September 24, 2024, at 12 PM EDT.
Mr. Robert Bitterman, CEO and Chairman of the Board, will present on behalf of Phio Pharmaceuticals. The company specializes in INTASYL® siRNA gene silencing technology, designed to enhance immune cells' effectiveness in killing tumor cells.
Stakeholders, investors, and interested individuals are invited to register and attend this live event. A replay will be available on the Renmark Financial Communications Inc. website. Attendees are advised to use the latest version of Google Chrome for optimal connectivity.
Phio Pharmaceuticals (NASDAQ: PHIO) announced a presentation at the 9th Annual CAR-TCR Summit in Boston, MA, showcasing its INTASYL self-delivering RNAi technology. The presentation, titled 'INTASYL Self-Delivering RNAi: A Flexible Platform to Improve Adoptive Cell Therapy,' will be given by Melissa Maxwell on September 17th. INTASYL is designed to enhance cell potency and yield in Adoptive Cell Therapy, potentially offering a more effective approach for cancer treatment. The technology aims to make immune cells more effective in killing tumor cells through gene silencing. This presentation highlights Phio's efforts to advance its innovative platform in the competitive field of cell therapy.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical stage biotech company, will participate in the H.C. Wainwright 26th Annual Global Investment Conference from September 9-11, 2024, in New York City. CEO Robert Bitterman will present on the company's INTASYL siRNA gene silencing technology, which aims to enhance immune cells' ability to kill tumor cells.
The presentation will cover:
- INTASYL technology overview
- Associated patents and intellectual property
- Ongoing Phase 1b clinical trial of PH-762, Phio's lead INTASYL compound
Phio's presentation will be streamed online starting September 9th at 7:00 AM ET. The management team will also be available for one-on-one meetings during the conference.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical stage biotech company specializing in INTASYL® siRNA gene silencing technology, has announced its participation in the Renmark Financial Communications Virtual Non-Deal Roadshow Series. The event is scheduled for Thursday, September 5, 2024, at 12 PM EDT.
Robert Bitterman, CEO and Chairman of the Board, will present on behalf of Phio Pharmaceuticals. The presentation will include a live Q&A session. Stakeholders, investors, and interested individuals are invited to register and attend this live event. A replay will be available on the Renmark Financial Communications website.
Phio's INTASYL® technology is designed to enhance the effectiveness of immune cells in killing tumor cells, positioning the company at the forefront of innovative cancer treatments.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) reported its Q2 2024 financial results and provided a business update. Key highlights include:
1. Positive safety recommendation for PH-762 Phase 1b trial, with no dose-limiting toxicities.
2. Addition of a fifth clinical trial site for the PH-762 study.
3. New patent granted in South Korea for INTASYL compounds targeting aging skin disorders.
4. Warrant exercise agreements resulting in $3.1 million gross proceeds.
5. Completion of a 1-for-9 reverse stock split.
6. Regained compliance with Nasdaq's minimum bid price requirement.
7. Appointment of Robert M. Infarinato as CFO.
8. Exploratory collaboration with a global skin care company.
Financial results show cash position of $4.7 million as of June 30, 2024, with decreased R&D and G&A expenses compared to Q2 2023.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) has announced an exploratory collaboration with a leading luxury skin care company to explore opportunities for its patented INTASYL compound in cosmeceutical applications. This collaboration aims to leverage Phio's gene silencing technology for aging skin disorders. CEO Robert Bitterman highlighted the significance of this step in demonstrating INTASYL's versatility across multiple applications.
Phio's INTASYL patent portfolio now includes 77 issued patents covering the silencing of over 25 gene targets in various fields, including dermatology, immuno-oncology, ophthalmology, and viral disorders. The technology is designed to enhance the effectiveness of immune cells in killing tumor cells, with applications for both intratumoral treatment and adoptive cell therapy.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO), a clinical stage biotechnology company specializing in INTASYL™ siRNA gene silencing technology, has announced the appointment of Robert M. Infarinato as their new Vice President and Chief Financial Officer, effective August 1, 2024. Infarinato brings over 20 years of financial and accounting leadership experience to the role, where he will serve as Principal Financial Officer overseeing accounting, finance, treasury, investor relations, and administration.
Infarinato's extensive background includes leadership positions in healthcare and pharmaceuticals, such as roles at Abington Health, Rhone Poulenc Rorer, and Pfizer. CEO Robert Bitterman expressed enthusiasm about Infarinato joining the executive team, highlighting his broad experience across multiple financial functions within the healthcare sector.
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