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Nurix Therapeutics Announces Presentations at the 7th Annual TPD & Induced Proximity Summit

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Nurix Therapeutics (Nasdaq: NRIX) announced presentations at the 7th Annual TPD & Induced Proximity Summit, October 28-31, 2024, in Boston. The company will present new preclinical data on a brain-penetrant, pan-mutant B-Raf degrader and recent clinical data from the NX-5948 BTK degrader program.

Key presentations include:

  • An orally bioavailable, brain-penetrant pan-mutant B-RAF degrader showing potent anti-tumor activity in multiple disease models
  • Clinical activity of NX-5948 in CLL & NHL, demonstrating utility in relapsed/refractory B-cell malignancies, including cases with CNS involvement and BTK inhibitor resistance mutations

Nurix executives will also participate in panel discussions on strategic partnerships and the future of targeted protein degradation. The company aims to showcase its leadership in the field and the therapeutic potential of its targeted protein modulation approach.

Nurix Therapeutics (Nasdaq: NRIX) ha annunciato presentazioni al 7° Annual TPD & Induced Proximity Summit, che si terrà dal 28 al 31 ottobre 2024 a Boston. L'azienda presenterà nuovi dati preclinici su un degradatore B-Raf pan-mutante in grado di penetrare nel cervello e dati clinici recenti dal programma di degradatori BTK NX-5948.

Le presentazioni chiave includono:

  • Un degradatore B-RAF pan-mutante bio disponibile per via orale che mostra una potente attività anti-tumorale in diversi modelli di malattia
  • Attività clinica di NX-5948 in CLL e NHL, dimostrando utilità nelle neoplasie maligne B-cellulari recidivanti/riferite, compresi i casi con coinvolgimento del SNC e mutazioni di resistenza agli inibitori BTK

Gli dirigenti di Nurix parteciperanno anche a discussioni di pannello su partnership strategiche e il futuro della degradazione proteica mirata. L'azienda mira a mostrare la sua leadership nel settore e il potenziale terapeutico del suo approccio alla modulazione proteica mirata.

Nurix Therapeutics (Nasdaq: NRIX) anunció presentaciones en la 7ª Cumbre Anual de TPD & Induced Proximity, que se llevará a cabo del 28 al 31 de octubre de 2024 en Boston. La compañía presentará nuevos datos preclínicos sobre un degradador B-Raf pan-mutante que penetra en el cerebro y datos clínicos recientes del programa de degradadores BTK NX-5948.

Las presentaciones clave incluyen:

  • Un degradador B-RAF pan-mutante bio-disponible por vía oral que muestra una potente actividad antitumoral en múltiples modelos de enfermedad
  • Actividad clínica de NX-5948 en CLL y NHL, demostrando utilidad en malignidades de células B refractarias/recaídas, incluidos los casos con afectación del SNC y mutaciones de resistencia a los inhibidores de BTK

Los ejecutivos de Nurix también participarán en discusiones en panel sobre asociaciones estratégicas y el futuro de la degradación proteica dirigida. La compañía tiene como objetivo mostrar su liderazgo en el campo y el potencial terapéutico de su enfoque de modulación proteica dirigida.

Nurix Therapeutics (Nasdaq: NRIX)는 2024년 10월 28일부터 31일까지 보스턴에서 열리는 제7회 연례 TPD 및 유도 근접 정상 회담에서 발표할 예정입니다. 이 회사는 새로운 전임상 데이터와 뇌 침투 저항 B-Raf 분해제를 발표하고 최근의 임상 데이터를 NX-5948 BTK 분해제 프로그램에서 공유할 것입니다.

주요 발표 내용은 다음과 같습니다:

  • 여러 질병 모델에서 강력한 항종양 활성을 보이는 경구 투여 가능한 뇌 침투성 판-돌연변이 B-RAF 분해제
  • CLL 및 NHL에서 NX-5948의 임상적 활성을 나타내며, CNS 침투 및 BTK 억제제 내성 변이가 있는 경우를 포함하여 재발/불응성 B세포 악성종양에서 효용을 입증합니다.

Nurix 임원들은 또한 전략적 파트너십 및 표적 단백질 분해의 미래에 대한 패널 토론에 참여할 것입니다. 이 회사는 해당 분야에서의 리더십과 표적 단백질 조절 접근법의 치료적 잠재력을 보여주는 것을 목표로 하고 있습니다.

Nurix Therapeutics (Nasdaq: NRIX) a annoncé des présentations lors de la 7e édition du TPD & Induced Proximity Summit, qui se tiendra du 28 au 31 octobre 2024 à Boston. L'entreprise présentera de nouvelles données précliniques sur un dégradateur B-Raf pan-mutant capable de pénétrer dans le cerveau et des données cliniques récentes du programme de dégradateurs BTK NX-5948.

Les présentations clés incluent :

  • Un dégradateur B-RAF pan-mutant, bio-disponible par voie orale, montrant une activité antitumorale puissante dans plusieurs modèles de maladies
  • Activité clinique de NX-5948 dans la CLL et la NHL, démontrant son utilité dans les malignités des cellules B récidivantes/réfractaires, y compris les cas avec implication du SNC et des mutations de résistance aux inhibiteurs de BTK

Les dirigeants de Nurix participeront également à des discussions en panel sur les partenariats stratégiques et l'avenir de la dégradation protéique ciblée. L'entreprise vise à mettre en avant son leadership dans ce domaine et le potentiel thérapeutique de son approche de modulation protéique ciblée.

Nurix Therapeutics (Nasdaq: NRIX) hat Präsentationen beim 7. jährlichen TPD & Induced Proximity Summit angekündigt, der vom 28. bis 31. Oktober 2024 in Boston stattfinden wird. Das Unternehmen wird neue präklinische Daten zu einem gehirngängigen, pan-mutante B-Raf-Degrader und aktuelle klinische Daten aus dem NX-5948 BTK-Degrader-Programm vorstellen.

Zu den wichtigsten Präsentationen gehören:

  • Ein oral bioverfügbarer, gehirngängiger pan-mutante B-RAF-Degrader, der in mehreren Krankheitsmodellen eine starke antitumorale Aktivität zeigt
  • Klinische Aktivität von NX-5948 bei CLL und NHL, die die Nützlichkeit bei rezidivierenden/refraktären B-Zell-Malignomen demonstriert, einschließlich Fälle mit CNS-Beteiligung und BTK-Inhibitor-Resistenzmutationen

Die Führungskräfte von Nurix werden auch an Podiumsdiskussionen über strategische Partnerschaften und die Zukunft der gezielten Proteinabbau teilnehmen. Das Unternehmen zielt darauf ab, seine Führungsposition in diesem Bereich und das therapeutische Potenzial seines Ansatzes zur gezielten Proteinmodulation zu präsentieren.

Positive
  • Development of a potent, selective, and orally bioavailable mutant-specific B-RAF degrader for oncology
  • Observed anti-tumor activity in multiple disease models, including CNS disease and treatment-resistant cases
  • NX-5948 showing clinical activity in relapsed/refractory B-cell malignancies, including CLL with CNS involvement
  • Advancement of NX-5948 into Phase 1b expansion cohorts
  • Demonstrated clinical activity in Waldenstrom's macroglobulinemia (WM)
Negative
  • None.

Presentations will summarize new preclinical data from brain-penetrant, pan-mutant B-Raf degrader program and recent clinical data from NX-5948 BTK degrader program

Members of the Nurix management team also to participate in several expert panel discussions

SAN FRANCISCO, Oct. 21, 2024 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with cancer and inflammatory diseases, today announced that members of the Nurix team will make oral presentations on Nurix programs and participate in several industry panel discussions at the 7th Annual TPD & Induced Proximity Summit, being held October 28–31, 2024, in Boston, MA.

“The growing interest in the targeted protein degradation field underscores the immense therapeutic potential of this approach,” said Arthur T. Sands, M.D., Ph.D., president and chief executive officer of Nurix. “As an early leader in this space, Nurix has developed a broad pipeline and established numerous successful collaborations. We are excited to share preclinical data from our previously undisclosed pan-mutant B-Raf selective degrader with CNS exposure along with a review of clinical data from our NX-5948 selective BTK degrader with updated case reports.”

Presentation and Panel Participation Details:

Presentations

Title: An Orally Bioavailable, Brain Penetrant Pan-Mutant B-RAF Degrader for the Treatment of Primary & Treatment-Resistant Solid Tumors
Presenting author: Ya-Wen Lu, Ph.D.
Session: Track B: Preclinical: Unearthing Brand New Bifunctional Modes of Action & Achieving Potent, Selective ADME Preclinically
Date and time: Tuesday, October 29th, at 11:30 AM ET
Description:

  • Nurix has developed a potent, selective, and orally bioavailable mutant-specific B-RAF degrader for use in oncology
  • Potent anti-tumor activity observed in multiple CDX and PDX disease models representing Class I, Class II and Class III B-RAF mutations.
  • Anti-tumor activity was also observed in the setting of CNS disease and treatment-resistance, suggesting the potential for utility across a broad range of solid tumor types

Title: Clinical Activity of NX-5948 in CLL & NHL: A First-in-Class BTK Degrader
Presenting author: Paula G. O’Connor, M.D., Chief Medical Officer, Nurix
Morning Keynote Plenary Session: Advancing Bifunctionals Towards the First Approval with Clinical Data from Leaders in the Clinic
Date and time: Wednesday, October 30th, at 9:00 AM ET.
Description:

  • NX-5948 is an investigational, orally bioavailable degrader of BTK that is currently being evaluated in relapsed or refractory B-cell malignancies and recently advanced into Phase 1b expansion cohorts.
  • Emerging data continues to support the utility of BTK degradation in patients with relapsed or refractory CLL including those with CNS involvement and with tumors harboring BTK inhibitor resistance mutations
  • Recent data demonstrates clinical activity in Waldenstrom’s macroglobulinemia (WM)
  • Updated case reports will be presented

The slides for these presentations may be accessed following their presentation at the 7th Annual TPD & Induced Proximity Summit, via links in the Scientific Resources section of the Nurix website.

Panel Discussions

CEO Think Tank: A Strategic Look at Targeted Protein Degradation & Induced Proximity Field
Panelist: Arthur T. Sands, M.D., Ph.D., President and CEO
Morning Keynote Plenary Session: Visions for the Future of TPD & Beyond: The CEO Perspective
Date and time: Tuesday, October 29th at 9:30 AM ET

Lessons Learned from a Major Strategic Partnership Deal for a Platform
Panelist: Jason Kantor Ph.D., Chief Business Officer
Closing Keynote Plenary Session: Preparing for the Future: Accelerating Strategy, Partnering & Investment for TPD & Beyond
Date and time: Wednesday, October 30th at 4:10 PM ET

Lessons Learned from a Major Strategic Partnership Deal for an Asset
Panelist: Jason Kantor Ph.D., Chief Business Officer
Closing Keynote Plenary Session: Preparing for the Future: Accelerating Strategy, Partnering & Investment for TPD & Beyond
Date and time: Wednesday, October 30th at 4:55 PM ET

About NX-5948

NX-5948 is an investigational, orally bioavailable degrader of BTK that is currently being evaluated in a Phase 1a/b clinical trial in adults with relapsed or refractory B-cell malignancies. Additional information on the Phase 1a/b clinical trial can be accessed at www.clinicaltrials.gov (NCT05131022).

About Nurix Therapeutics, Inc.

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of innovative small molecules and antibody therapies based on the modulation of cellular protein levels as a novel treatment approach for cancer, inflammatory conditions, and other challenging diseases. Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform, to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin-proteasome system to selectively decrease or increase cellular protein levels. Nurix’s wholly owned, clinical stage pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates activation of multiple immune cell types including T cell and NK cells. Nurix is headquartered in San Francisco, California. For additional information visit http://www.nurixtx.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and other federal securities laws. Any statements contained herein that do not describe historical facts, including, but not limited to, statements regarding the planned timing for the provision of updates and findings from preclinical studies and clinical trials, including Nurix’s intention to present preclinical data and updated clinical reports at the 7th Annual TPD & Induced Proximity Summit, are forward-looking statements that involve risks and uncertainties that could cause actual results to differ materially from those discussed in such forward-looking statements. Such risks and uncertainties include, among others, the risks described under the heading “Risk Factors” in Nurix’s Quarterly Report on Form 10-Q for the period ended August 31, 2024, and subsequent filings with the SEC. Any of these risks and uncertainties could materially and adversely affect Nurix’s business and results of operations, which could, in turn, have a significant and adverse impact on Nurix’s stock price. Nurix cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. Nurix undertakes no obligation to update publicly any forward-looking statements to reflect new information, events or circumstances after the date they were made or to reflect the occurrence of unanticipated events.

Contacts:

Investors
Jason Kantor, Ph.D.
Nurix Therapeutics, Inc.
ir@nurixtx.com

Elizabeth Wolffe, Ph.D.
Wheelhouse Life Science Advisors
lwolffe@wheelhouselsa.com

Media
Aljanae Reynolds
Wheelhouse Life Science Advisors
areynolds@wheelhouselsa.com


FAQ

What new data will Nurix Therapeutics (NRIX) present at the 7th Annual TPD & Induced Proximity Summit?

Nurix will present new preclinical data on a brain-penetrant, pan-mutant B-Raf degrader and recent clinical data from the NX-5948 BTK degrader program, including updated case reports.

What are the key features of Nurix Therapeutics' (NRIX) new B-RAF degrader?

Nurix's new B-RAF degrader is orally bioavailable, brain-penetrant, and pan-mutant specific. It has shown potent anti-tumor activity in multiple CDX and PDX disease models, including CNS disease and treatment-resistant cases.

What clinical progress has Nurix Therapeutics (NRIX) made with NX-5948?

NX-5948 has shown clinical activity in relapsed/refractory B-cell malignancies, including CLL with CNS involvement and BTK inhibitor resistance mutations. It has advanced into Phase 1b expansion cohorts and demonstrated activity in Waldenstrom's macroglobulinemia.

When and where will Nurix Therapeutics (NRIX) present at the TPD & Induced Proximity Summit?

Nurix will present at the 7th Annual TPD & Induced Proximity Summit, held from October 28-31, 2024, in Boston, MA. Specific presentation times are October 29th at 11:30 AM ET and October 30th at 9:00 AM ET.

Nurix Therapeutics, Inc.

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