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Mersana Therapeutics, Inc. (NASDAQ: MRSN) is a clinical-stage biopharmaceutical company dedicated to developing innovative antibody-drug conjugates (ADCs) aimed at improving the lives of cancer patients. Leveraging their proprietary Fleximer platform, Mersana is rewriting the rules for immunoconjugate therapies by creating precisely targeted and highly tailored drugs. This platform allows for the custom design of ADCs with specific properties that overcome current limitations and enhance the drug's effectiveness against particular cancers, while minimizing side effects.
Mersana's lead product candidate, Upifitamab Rilsodotin (UpRi), utilizes the Dolaflexin platform and targets the NaPi2b protein, primarily for the treatment of platinum-resistant ovarian cancer. Although the UPLIFT clinical trial did not meet its primary endpoint, the company is conducting in-depth analyses to understand the results and potential future steps for UpRi.
Among its pipeline, Mersana's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, and XMT-2056, a STING agonist ADC developed using the Immunosynthen platform, which targets a novel epitope of human epidermal growth factor receptor 2 (HER2). Mersana is advancing XMT-1660 in its Phase 1 clinical trial, with plans to initiate dose expansion in 2024. For XMT-2056, Mersana has resumed enrollment in its Phase 1 clinical trial following the lifting of a clinical hold by the FDA.
Mersana collaborates with multiple partners, such as Janssen Biotech and Merck KGaA, to advance their ADC pipelines using Mersana’s innovative platforms. Additionally, the company continues to strengthen its financial position, reporting substantial cash reserves to support its operations into 2026.
With a focus on developing next-generation ADCs, Mersana remains committed to delivering meaningful clinical benefits to cancer patients through its robust pipeline and strategic partnerships.
Mersana Therapeutics (NASDAQ:MRSN) has announced promising preclinical data for XMT-2056, its first Immunosynthen STING-agonist ADC candidate, targeting a novel epitope of HER2. Presented at the AACR-NCI-EORTC conference, data shows that XMT-2056 activates the STING pathway effectively in tumor cells and immune cells, outperforming trastuzumab-TLR7/8 agonist ADCs. The ADC demonstrates increased efficacy in various HER2 models and potential for combination treatments with existing HER2 therapies. The compound also shows excellent tolerability in NHP studies, suggesting a broad therapeutic index.
Mersana Therapeutics (NASDAQ:MRSN) announced its upcoming presentation of preclinical data for XMT-2056, its first STING-agonist ADC, at the AACR-NCI-EORTC Virtual Conference on Molecular Targets and Cancer Therapeutics. The session is scheduled for October 7, 2021, featuring Dr. Timothy B. Lowinger, the Chief Science & Technology Officer. This event highlights Mersana's innovations in antibody-drug conjugates aimed at targeting cancers with significant unmet medical needs, strengthening its pipeline that includes UpRi and XMT-1592.
Mersana Therapeutics (NASDAQ:MRSN), a clinical-stage biopharmaceutical company, announced management presentations at three investor conferences. The Baird 2021 Global Healthcare Conference will take place on September 14, 2021, at 8:30 a.m. ET, followed by the Morgan Stanley 19th Annual Global Healthcare Conference on September 15, 2021, at 1:15 p.m. ET. Lastly, the 2021 Cantor Virtual Global Healthcare Conference is set for September 28, 2021, at 4:00 p.m. ET. A live webcast will be accessible on Mersana's website, with an archived replay available for 90 days.
Mersana Therapeutics (NASDAQ:MRSN) has announced a live conference call and webcast on September 10, 2021, at 8:00 a.m. ET to discuss the development strategy of its ADC candidate, upifitamab rilsodotin (UpRi), and share updated interim data from the ovarian cancer expansion cohort of the Phase 1 study. The expansion cohort has completed enrollment with 97 patients evaluable for safety, of which 75 are RECIST-evaluable. Key executives, including lead investigator Debra L. Richardson, MD, will participate in the call.
Mersana Therapeutics (Nasdaq: MRSN) has announced the appointment of Tushar Misra, Ph.D., as Senior Vice President and Chief Manufacturing Officer, with a stock option grant of up to 112,500 shares priced at $11.56 each. This grant serves as an inducement for Dr. Misra's employment and vests over four years. Mersana specializes in antibody-drug conjugates (ADCs) for cancer treatment, with lead candidate upifitamab rilsodotin currently in clinical studies for ovarian cancer. The company aims to enhance efficacy and safety in treating cancer patients.
Mersana Therapeutics has appointed Tushar Misra, Ph.D., as its new Chief Manufacturing Officer, effective August 16, 2021. He takes over from Michael Kaufman, Ph.D., who will retire following a transition period ending on September 10, 2021. Misra brings extensive experience from his previous roles in major biopharmaceutical companies. His leadership is expected to advance the company’s clinical programs, particularly for UpRi, aimed at treating ovarian cancer.
Mersana Therapeutics (NASDAQ:MRSN) reported its Q2 2021 financial results, ending with $227.4 million in cash. Significant updates include the initiation of the UPGRADE Phase 1 study for Upifitamab Rilsodotin (UpRi) in platinum-sensitive ovarian cancer, and the ongoing exploration of ADC candidates like XMT-1592 and XMT-2056. The company also recorded a net loss of $40.9 million, or $0.59 per share, compared to a net loss of $19.8 million, or $0.33 per share in Q2 2020. Mersana aims to enhance its ADC pipeline while maintaining financial stability.
Mersana Therapeutics, Inc. (NASDAQ:MRSN) announced its participation in the virtual panel at the 12th Annual Wedbush PacGrow Healthcare Conference on August 11, 2021, at 2:20 p.m. ET. The event will showcase the company's progress in developing antibody-drug conjugates (ADCs) targeting cancer. A live webcast will be available on their website, followed by an archived replay for 90 days. Mersana’s lead candidate, upifitamab rilsodotin (UpRi), is currently in trials for platinum-resistant ovarian cancer and NSCLC adenocarcinoma, alongside several other ADC programs.
Mersana Therapeutics (NASDAQ:MRSN) announced a conference call on August 6, 2021, at 8:00 a.m. ET to report its Q2 2021 financial results and provide business updates. The company focuses on developing antibody-drug conjugates (ADCs) for cancer treatment, with its lead candidate, upifitamab rilsodotin (UpRi), under investigation for platinum-resistant ovarian cancer and non-small cell lung cancer (NSCLC). Mersana’s platform is also supporting ADC development for multiple partners, highlighting its commitment to innovation in cancer therapies.
Mersana Therapeutics (NASDAQ:MRSN) has launched the UPGRADE study, a Phase 1 clinical trial evaluating the combination of upifitamab rilsodotin (UpRi) and carboplatin in patients with platinum-sensitive ovarian cancer. This study aims to determine the maximum tolerated dose and safety of UpRi over six cycles followed by monotherapy. Early results indicate UpRi's favorable tolerability profile without severe adverse effects commonly seen with other therapies. The study's initiation marks a critical step in advancing UpRi as a foundational treatment for ovarian cancer.
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