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Mersana Therapeutics, Inc. (NASDAQ: MRSN) is a clinical-stage biopharmaceutical company dedicated to developing innovative antibody-drug conjugates (ADCs) aimed at improving the lives of cancer patients. Leveraging their proprietary Fleximer platform, Mersana is rewriting the rules for immunoconjugate therapies by creating precisely targeted and highly tailored drugs. This platform allows for the custom design of ADCs with specific properties that overcome current limitations and enhance the drug's effectiveness against particular cancers, while minimizing side effects.
Mersana's lead product candidate, Upifitamab Rilsodotin (UpRi), utilizes the Dolaflexin platform and targets the NaPi2b protein, primarily for the treatment of platinum-resistant ovarian cancer. Although the UPLIFT clinical trial did not meet its primary endpoint, the company is conducting in-depth analyses to understand the results and potential future steps for UpRi.
Among its pipeline, Mersana's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, and XMT-2056, a STING agonist ADC developed using the Immunosynthen platform, which targets a novel epitope of human epidermal growth factor receptor 2 (HER2). Mersana is advancing XMT-1660 in its Phase 1 clinical trial, with plans to initiate dose expansion in 2024. For XMT-2056, Mersana has resumed enrollment in its Phase 1 clinical trial following the lifting of a clinical hold by the FDA.
Mersana collaborates with multiple partners, such as Janssen Biotech and Merck KGaA, to advance their ADC pipelines using Mersana’s innovative platforms. Additionally, the company continues to strengthen its financial position, reporting substantial cash reserves to support its operations into 2026.
With a focus on developing next-generation ADCs, Mersana remains committed to delivering meaningful clinical benefits to cancer patients through its robust pipeline and strategic partnerships.
Mersana Therapeutics (NASDAQ:MRSN) announced today that its management team will hold a fireside chat at the 4th Annual Evercore ISI HealthCONx Conference on December 1, 2021, at 2:40 p.m. ET. A live webcast will be accessible through the Investors & Media section of Mersana’s website, with an archived replay available for 90 days post-event. The company focuses on developing antibody-drug conjugates (ADCs) aimed at addressing high unmet medical needs in cancer treatment, including lead candidate upifitamab rilsodotin targeting platinum-resistant ovarian cancer.
Mersana Therapeutics (NASDAQ:MRSN), a biopharmaceutical company focused on antibody-drug conjugates (ADCs), announced that CEO Anna Protopapas will present a company overview at the Stifel 2021 Virtual Healthcare Conference on November 17, 2021, at 3:20 p.m. ET. Investors can access a live webcast on Mersana's website, with an archived replay available for 90 days post-event. Mersana is developing innovative ADCs to improve cancer treatment, with its lead candidate, upifitamab rilsodotin (UpRi), targeting platinum-resistant ovarian cancer.
Mersana Therapeutics (NASDAQ:MRSN) reported significant advancements in its clinical pipeline, particularly regarding UpRi, a treatment for ovarian cancer. Updated data showed a confirmed objective response rate (ORR) of 34% in patients with NaPi2b high ovarian cancer, supporting the ongoing UPLIFT study. The company introduced UP-NEXT, a Phase 3 study for UpRi maintenance therapy in platinum-sensitive patients. Financially, Mersana ended Q3 2021 with about $192 million in cash and new credit access of $100 million, bolstering its operational capabilities.
Mersana Therapeutics (NASDAQ:MRSN) announced a conference call on November 9, 2021, at 8:00 a.m. ET to discuss third-quarter financial results ending September 30, 2021. The clinical-stage biopharmaceutical company specializes in antibody-drug conjugates (ADCs) for cancer treatment and is developing several product candidates, including upifitamab rilsodotin (UpRi). UpRi targets NaPi2b and is under evaluation in multiple studies for ovarian cancer treatment. Investors can access the call via phone or webcast through the company’s website.
Mersana Therapeutics (Nasdaq: MRSN) has appointed Mohan Bala, Ph.D., as Senior Vice President of Strategic Product Planning & Program Leadership. To entice Dr. Bala, the Compensation Committee granted him a stock option for 112,500 shares at $8.63 per share, the closing price on the grant date. The options will vest over four years, with 25% vesting on the first anniversary of his start date and the remainder vesting quarterly. Mersana is focused on developing antibody-drug conjugates (ADCs) for cancer treatment, including their lead candidate UpRi for ovarian cancer.
Mersana Therapeutics has appointed Mohan Bala, Ph.D., as SVP, Strategic Product Planning & Program Leadership, effective October 25, 2021. He takes over responsibilities from Brian DeSchuytner, who has been named SVP and Chief Financial Officer. Dr. Bala brings over 20 years of experience in clinical development, having launched seven oncology products globally. This leadership change is expected to strengthen Mersana's efforts in advancing its clinical pipeline, especially UpRi, a candidate for treating ovarian cancer.
Mersana Therapeutics (NASDAQ:MRSN) has announced promising preclinical data for XMT-2056, its first Immunosynthen STING-agonist ADC candidate, targeting a novel epitope of HER2. Presented at the AACR-NCI-EORTC conference, data shows that XMT-2056 activates the STING pathway effectively in tumor cells and immune cells, outperforming trastuzumab-TLR7/8 agonist ADCs. The ADC demonstrates increased efficacy in various HER2 models and potential for combination treatments with existing HER2 therapies. The compound also shows excellent tolerability in NHP studies, suggesting a broad therapeutic index.
Mersana Therapeutics (NASDAQ:MRSN) announced its upcoming presentation of preclinical data for XMT-2056, its first STING-agonist ADC, at the AACR-NCI-EORTC Virtual Conference on Molecular Targets and Cancer Therapeutics. The session is scheduled for October 7, 2021, featuring Dr. Timothy B. Lowinger, the Chief Science & Technology Officer. This event highlights Mersana's innovations in antibody-drug conjugates aimed at targeting cancers with significant unmet medical needs, strengthening its pipeline that includes UpRi and XMT-1592.
Mersana Therapeutics (NASDAQ:MRSN), a clinical-stage biopharmaceutical company, announced management presentations at three investor conferences. The Baird 2021 Global Healthcare Conference will take place on September 14, 2021, at 8:30 a.m. ET, followed by the Morgan Stanley 19th Annual Global Healthcare Conference on September 15, 2021, at 1:15 p.m. ET. Lastly, the 2021 Cantor Virtual Global Healthcare Conference is set for September 28, 2021, at 4:00 p.m. ET. A live webcast will be accessible on Mersana's website, with an archived replay available for 90 days.
Mersana Therapeutics (NASDAQ:MRSN) has announced a live conference call and webcast on September 10, 2021, at 8:00 a.m. ET to discuss the development strategy of its ADC candidate, upifitamab rilsodotin (UpRi), and share updated interim data from the ovarian cancer expansion cohort of the Phase 1 study. The expansion cohort has completed enrollment with 97 patients evaluable for safety, of which 75 are RECIST-evaluable. Key executives, including lead investigator Debra L. Richardson, MD, will participate in the call.
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