Lantern Pharma Inc - LTRN STOCK NEWS

Lantern Pharma (NASDAQ: LTRN) has expanded its clinical development team, appointing Dr. Reggie Ewesuedo as Vice President of Clinical Development. This strategic move aims to advance the ongoing Harmonic™ trial for non-small cell lung cancer (NSCLC) and initiate first-in-human Phase 1 trials for drug candidates LP-184 and LP-284, projected to launch in mid-2023. Dr. Ewesuedo brings over 20 years of experience in drug development, enhancing the company's capabilities in oncology. The team also welcomes Ernest Kitt as Head of Clinical Operations and other professionals to bolster their clinical efforts.

Lantern Pharma announced a collaboration with TTC Oncology to utilize its AI platform, RADR^®, in advancing the clinical development of TTC-352, a selective human estrogen receptor partial agonist (ShERPA) for metastatic ER+ breast cancer. This innovative drug candidate is positioned as first-in-class, targeting patients who have failed previous therapies. As part of the agreement, Lantern gains exclusive licensing rights to TTC-352 and any resulting intellectual property. The partnership aims to leverage over 25 billion oncology-focused data points and advanced machine learning algorithms for patient selection and drug development insights, enhancing potential market reach.

Lantern Pharma Inc. (NASDAQ: LTRN) is enhancing its RADR^® platform to support the development of Antibody Drug Conjugates (ADCs). This initiative aims to advance ADC candidates to first-in-human trials in around two years, bolstered by a library of over 200 algorithms and 25 billion oncology-focused data points. The ADC market, currently valued at over $4 billion, is projected to grow to $14 billion by 2027. The expansion includes new AI and ML strategies for drug candidate identification, patient stratification, and improved payload delivery, positioning Lantern for significant business development opportunities.

Lantern Pharma (NASDAQ: LTRN) has received FDA guidance for its LP-184 program aimed at treating various cancers, including CNS cancers. The feedback aligns with Lantern's plans for an IND submission and a first-in-human clinical trial scheduled for Q2 2023. LP-184 demonstrates significant potency against multiple cancers and aims to improve outcomes for patients with high unmet needs. The trial will focus on pancreatic cancer and glioblastoma, leveraging Lantern's RADR® AI platform for patient identification. The company anticipates impactful results that could benefit both patients and shareholders.

Lantern Pharma (NASDAQ: LTRN) announced that the FDA has granted Orphan Drug Designation for LP-284, aimed at treating mantle cell lymphoma (MCL). This designation enhances LP-284’s clinical development and offers seven years of market exclusivity. Lantern expects to file an IND and begin a Phase 1 trial for LP-284 in MCL by mid-2023. MCL affects around 4,500 patients annually in the U.S., with a market potential of $600 million. The drug demonstrated significant anti-tumor activity in preclinical models, particularly against resistant tumors.

Lantern Pharma (NASDAQ: LTRN) released positive preclinical data for LP-284, targeting Mantle Cell Lymphoma (MCL), presented at the American Society of Hematology Meeting. The data indicates LP-284's superior tumor growth inhibition compared to traditional therapies like Ibrutinib and Bortezomib, achieving a TGI of 113%. Lantern plans to file an IND with the FDA in early 2023 and initiate a Phase 1 trial mid-2023. MCL and double hit lymphoma (DHL) represent about 9,000 new cases annually, with a market potential of $1.2 billion USD.

Lantern Pharma Inc. (NASDAQ: LTRN) announced significant findings at the SABCS 2022, highlighting the promising anti-tumor effects of its drug candidate LP-184 against Triple Negative Breast Cancer (TNBC). LP-184 demonstrated an average IC50 of 297nM across four TNBC cell lines and achieved a remarkable 107-141% tumor regression in 10 resistant tumor models. The annual market for TNBC represents approximately $1.7 billion USD. The expansion of LP-184's indications may enhance its long-term value and address unmet needs in solid tumors.

Lantern Pharma (NASDAQ: LTRN) announced that CEO Panna Sharma will present at the RHK Capital Disruptive Growth Conference in New York City on December 5, 2022, at 12:00 p.m. ET. This conference will showcase around 30 innovative companies, connecting them with institutional and accredited investors.

Lantern Pharma leverages its RADR® AI platform for oncology drug development, focusing on genomically-targeted therapies, with four candidates in progress.

Lantern Pharma (NASDAQ: LTRN) announced positive preclinical data for its drug candidate LP-184 targeting glioblastoma (GBM) at the Society for Neuro-Oncology annual meeting. The study showed LP-184's efficacy either alone or combined with spironolactone, outperforming the standard treatment Temozolomide (TMZ) in resistant models. LP-184 has the potential market of $1.5-2.0 billion, with ongoing collaborative research with Johns Hopkins aimed at advancing it to clinical trials in 2023. The drug holds Orphan Drug and Rare Pediatric Disease designations, emphasizing its potential in oncology.