Lantern Pharma Inc. - LTRN STOCK NEWS

Lantern Pharma Inc. (NASDAQ: LTRN) announced that it has no exposure to Silicon Valley Bank, Silvergate Bank, or Signature Bank, ensuring its financial stability. The company’s cash, cash equivalents, and marketable securities are managed through top-tier financial institutions, providing sufficient resources to support operations and development through 2025. Lantern Pharma utilizes its proprietary RADR® AI platform to enhance oncology drug discovery, focusing on genomic profiling to identify patients likely to benefit from its therapeutics. This strategic approach aims to improve treatment outcomes for cancer patients.

Lantern Pharma (NASDAQ: LTRN) announced new findings supporting the development of LP-100 combined with PARP inhibitors for treating metastatic prostate cancer and other indications. Synergistic effects were observed in studies using LP-100 alongside notable PARP agents like Olaparib. Preliminary Phase 2 trial data indicated a median overall survival of 12.5 months for nine patients in Denmark, better than comparable treatment regimens. Future market potential for LP-100 is estimated between $700 million and $2 billion. This strategic focus aims to maximize LP-100's market opportunities while enhancing treatment pathways for patients with specific gene mutations.

Lantern Pharma (NASDAQ: LTRN) will host a virtual key opinion leader (KOL) webinar on March 21, 2023, at 12:00 p.m. ET, focusing on synthetic lethality in oncology. Dr. Zoltan Szallasi, a prominent expert, will discuss the mechanism of action behind Lantern's drug candidate LP-184 and its implications for solid tumors. Attendees will learn about the history of synthetic lethality, how it targets DNA damage repair deficiencies, and LP-184's potential to enhance cancer treatments. Registration is available here. A replay will be accessible on Lantern's website following the event.

Lantern Pharma (NASDAQ: LTRN) announces the formation of a wholly-owned subsidiary, Starlight Therapeutics, focused on developing therapies for CNS and brain cancers. Leveraging the RADR^® AI platform, Starlight's lead candidate, STAR-001, shows promising results in in-vitro and in-vivo studies, demonstrating blood-brain barrier permeability and nanomolar potency. Clinical trials are expected in late 2023 and early 2024 for indications with over 500,000 new cases annually and a market potential exceeding $6 billion. The formation aims to enhance clinical development, increase partnership opportunities, and improve patient outcomes.

Lantern Pharma (NASDAQ: LTRN) has expanded its clinical development team, appointing Dr. Reggie Ewesuedo as Vice President of Clinical Development. This strategic move aims to advance the ongoing Harmonic™ trial for non-small cell lung cancer (NSCLC) and initiate first-in-human Phase 1 trials for drug candidates LP-184 and LP-284, projected to launch in mid-2023. Dr. Ewesuedo brings over 20 years of experience in drug development, enhancing the company's capabilities in oncology. The team also welcomes Ernest Kitt as Head of Clinical Operations and other professionals to bolster their clinical efforts.

Lantern Pharma announced a collaboration with TTC Oncology to utilize its AI platform, RADR^®, in advancing the clinical development of TTC-352, a selective human estrogen receptor partial agonist (ShERPA) for metastatic ER+ breast cancer. This innovative drug candidate is positioned as first-in-class, targeting patients who have failed previous therapies. As part of the agreement, Lantern gains exclusive licensing rights to TTC-352 and any resulting intellectual property. The partnership aims to leverage over 25 billion oncology-focused data points and advanced machine learning algorithms for patient selection and drug development insights, enhancing potential market reach.

Lantern Pharma Inc. (NASDAQ: LTRN) is enhancing its RADR^® platform to support the development of Antibody Drug Conjugates (ADCs). This initiative aims to advance ADC candidates to first-in-human trials in around two years, bolstered by a library of over 200 algorithms and 25 billion oncology-focused data points. The ADC market, currently valued at over $4 billion, is projected to grow to $14 billion by 2027. The expansion includes new AI and ML strategies for drug candidate identification, patient stratification, and improved payload delivery, positioning Lantern for significant business development opportunities.

Lantern Pharma (NASDAQ: LTRN) has received FDA guidance for its LP-184 program aimed at treating various cancers, including CNS cancers. The feedback aligns with Lantern's plans for an IND submission and a first-in-human clinical trial scheduled for Q2 2023. LP-184 demonstrates significant potency against multiple cancers and aims to improve outcomes for patients with high unmet needs. The trial will focus on pancreatic cancer and glioblastoma, leveraging Lantern's RADR® AI platform for patient identification. The company anticipates impactful results that could benefit both patients and shareholders.

Lantern Pharma (NASDAQ: LTRN) announced that the FDA has granted Orphan Drug Designation for LP-284, aimed at treating mantle cell lymphoma (MCL). This designation enhances LP-284’s clinical development and offers seven years of market exclusivity. Lantern expects to file an IND and begin a Phase 1 trial for LP-284 in MCL by mid-2023. MCL affects around 4,500 patients annually in the U.S., with a market potential of $600 million. The drug demonstrated significant anti-tumor activity in preclinical models, particularly against resistant tumors.