Lantern Pharma Inc. develops AI-driven precision oncology therapies and research platforms for cancer drug discovery. The company uses its proprietary RADR® platform to identify and advance small-molecule oncology candidates, including LP-300, LP-184 and LP-284, and develops STAR-001 for CNS cancers through Starlight Therapeutics, its wholly owned subsidiary.
Recurring news includes clinical-program updates for lung cancer, hematologic cancers, sarcomas and brain cancers; FDA and trial-design communications; financial results; and commercialization of AI tools such as withZeta.ai and predictBBB.ai. Company updates also cover subscription-based platform access, computational biology features and enterprise deployment for biomedical research and drug-development users.
Lantern Pharma (NASDAQ: LTRN) announced an extension of its share repurchase program through July 31, 2022, allowing for the acquisition of up to $7 million in common stock. Since November 2021, the program has seen the repurchase of 475,157 shares at a cost of approximately $3.4 million. An additional $3.6 million is available for future purchases. As of December 31, 2021, the company reported $70.7 million in cash and equivalents, indicating strong liquidity to support the buyback initiative.
Lantern Pharma (NASDAQ: LTRN) announced promising preclinical data for its drug candidate LP-184 at the upcoming AACR annual meeting, scheduled for April 8-13, 2022. LP-184 showed significant anti-tumor activity in brain metastases models from lung, skin, and breast cancers, achieving 6 times greater potency than standard therapies. This small molecule drug targets DNA in cancer cells, particularly beneficial for patients with CNS cancers due to its favorable blood-brain barrier permeability. The FDA has granted LP-184 Orphan Drug and Rare Pediatric Disease designations, expediting its path toward clinical trials.
Lantern Pharma (NASDAQ: LTRN) reported its financial results for Q4 and the fiscal year 2021, marking a pivotal year with significant growth and clinical advancements. The RADR® A.I. platform achieved a remarkable 1,000% growth, surpassing 18 billion data points, and is projected to exceed 25 billion by the end of 2022. The company plans to initiate multiple clinical trials in 2022, including the Phase 2 trial for LP-300 in non-small cell lung cancer. Lantern raised $69 million in 2021, extending its cash runway into 2025, while reporting a net loss of $12.4 million for the year.
Lantern Pharma (LTRN), a clinical-stage biopharmaceutical company, will hold a conference call on March 10, 2022, at 4:30 p.m. ET to discuss its fourth quarter and fiscal year 2021 financial results. Management, led by CEO Panna Sharma, will provide insights into the company's operating performance and guidance on upcoming milestones. Lantern Pharma specializes in oncology drug development leveraging its RADR® A.I. platform to enhance patient targeting for drug trials. The call will also be available via a replay on their investor relations website.
Lantern Pharma (NASDAQ: LTRN) announced a collaboration with The Greehey Children's Cancer Research Institute to expand its drug candidates, LP-184 and LP-284, into rare pediatric cancers. This partnership aims to validate findings from the RADR® platform and advance treatments for difficult-to-treat tumors like rhabdomyosarcoma and ATRT. The collaboration leverages GCCRI's expertise and models, seeking to accelerate pediatric cancer therapy development at reduced costs. Lantern has previously received FDA orphan drug designations for LP-184.
Lantern Pharma (LTRN) announced that the FDA granted Rare Pediatric Disease Designation and Orphan Drug Designation for its drug candidate LP-184, aimed at treating pediatric patients with ATRT (Atypical Teratoid Rhabdoid Tumor). LP-184 is also being investigated for genetically defined solid tumors like pancreatic cancer and GBM. The Rare Pediatric Disease designation may allow Lantern to receive a priority review voucher for future product applications. The firm focuses on using its RADR® A.I. platform to identify effective treatments tailored to patient genetics.
Lantern Pharma (NASDAQ: LTRN) announced a collaboration with The Danish Cancer Society Research Center to advance clinical development of its drug candidates, LP-100 and LP-184. This partnership aims to enhance diagnostic methods for identifying NER-deficient tumors. The collaboration will leverage Lantern's RADR® AI platform, potentially adding millions of data points and expediting cancer treatment discovery. Both LP-100 and LP-184 have shown promise in targeting NER deficiencies, with LP-100 currently in a phase 2 trial for metastatic prostate cancer, showing improved overall survival rates.
Lantern Pharma (LTRN) has expanded its collaboration with the National Cancer Institute (NCI) to enhance the development of its oncology drug candidates, LP-184 and LP-284. This partnership aims to leverage multiomic data to identify gene signatures predicting tumor responses. LP-184 is targeting pancreatic cancer and glioblastoma, while LP-284 focuses on leukemias and lymphomas. Initial results suggest LP-184 may be more effective in tumors resistant to current treatments. The partnership will continue to refine predictive biomarkers and advance clinical trials, with results expected to be published in peer-reviewed journals.
Lantern Pharma (NASDAQ: LTRN), a clinical-stage biopharmaceutical company, announced its CEO Panna Sharma will present at the H.C. Wainwright BioConnect 2022 Conference from January 10-13, 2022. The presentation will be a fireside chat with analyst Michael King and will be available on-demand for attendees starting January 10 at 7:00 AM ET. Lantern Pharma utilizes its RADR® A.I. platform for oncology drug development, focusing on biomarker identification to enhance treatment outcomes for patients. More information can be found on their website.
On December 14, 2021, Lantern Pharma (NASDAQ: LTRN) announced positive data on LP-284's efficacy against hematologic cancers presented at the ASH Annual Meeting. LP-284, a synthetic acylfulvene compound, showcased broad anti-tumor activity against lymphoma, multiple myeloma, and leukemia in vitro. The findings suggest LP-284 could serve as a targeted therapy option for cancers with DNA repair deficiencies. Lantern plans to leverage its RADR® A.I. platform to advance LP-284 development and address the urgent need for new treatment options in blood cancers.