Lantern Pharma Inc - LTRN STOCK NEWS

Lantern Pharma (NASDAQ: LTRN) has announced advancements in its RADR® AI platform for optimizing antibody-drug conjugate (ADC) development. The company's AI-driven approach has successfully identified 82 promising ADC targets and 290 target-indication combinations, while validating 729 potential payload molecules from over 50,000 compounds.

The research demonstrated that 22 targets have been clinically validated, while 60 novel targets present new intellectual property opportunities. The platform's payload molecules showed exceptional potency with GI50 values from picomolar to 10 nM ranges. According to the company, this AI-driven approach could reduce ADC development timelines by 30-50% and cut costs by up to 60% compared to traditional methods.

The global ADC market is projected to reach $30.4 billion by 2028, growing at a CAGR of 41.7%. The company is advancing multiple ADC candidates through preclinical development, including a collaboration with the MAGICBULLET::Reloaded Initiative at the University of Bielefeld.

Lantern Pharma (NASDAQ: LTRN) has announced the enrollment and dosing of its first patient in Taiwan for the Phase 2 HARMONIC™ clinical trial of LP-300. The trial targets never-smoker patients with non-small cell lung cancer (NSCLC) who have progressed after tyrosine kinase inhibitor treatment.

The expansion into Taiwan is strategically significant as over 50% of lung cancer cases there occur in never-smokers. The trial follows encouraging preliminary results showing an 86% clinical benefit rate and 43% objective response rate among the first seven patients.

The Phase 2 trial will enroll up to 90 patients across two treatment arms: 60 patients receiving LP-300 with standard chemotherapy, and 30 receiving standard chemotherapy alone. The study will compare progression-free survival and median overall survival between the groups.

Lantern Pharma (NASDAQ: LTRN) announced that its drug candidate LP-184 received FDA Fast Track Designation for treating Triple Negative Breast Cancer (TNBC), marking its second such designation in 2024 following one for Glioblastoma. TNBC affects approximately 29,000 patients annually in the US, with over 50% relapsing within 3-5 years. LP-184, currently in Phase 1A clinical trials, has shown significant preclinical efficacy in TNBC models, including tumor regression of 107-141% in PDX models. The drug has demonstrated promising synergy with checkpoint inhibitors and effectiveness against PARP inhibitor-resistant cases.

Lantern Pharma and its subsidiary Starlight Therapeutics presented new preclinical data and Phase 1b trial design for LP-184 (STAR-001) in glioblastoma at SNO 2024. The data shows LP-184 combined with spironolactone increases GBM cell sensitivity up to 6-fold through ERCC3 degradation. The drug demonstrates favorable brain penetrance and effectiveness in temozolomide-resistant GBM models. Currently in Phase 1a trials, LP-184 has shown no dose-limiting toxicities across nine patient cohorts. The planned Phase 1b trial will evaluate LP-184 as both monotherapy and in combination with spironolactone in patients with IDH wild type GBM at first progression.

Lantern Pharma (NASDAQ: LTRN) has announced the first patient dosing in Japan for its Phase 2 HARMONIC™ clinical trial of LP-300 in never-smoker NSCLC patients. The trial, now expanded to ten sites across Japan and Taiwan, focuses on patients who have progressed after TKI treatment. Initial results from the U.S. trial showed an 86% clinical benefit rate and 43% objective response rate among the first seven patients. The expansion is significant as NSCLC in never-smokers occurs 2-3 times more frequently in East Asian countries, with Japan reporting 33-40% of new lung cancer cases in never-smokers.

Lantern Pharma reported Q3 2024 financial results and clinical updates. The company's LP-300 Harmonic™ Trial showed an 86% clinical benefit rate in initial patients and expanded to Japan and Taiwan. Phase 1 trials for LP-184 and LP-284 continue with no dose-limiting toxicities. LP-184 received FDA Fast Track Designation for Glioblastoma. Financial highlights include $28.1 million in cash and equivalents, R&D expenses of $3.7 million, and a net loss of $4.5 million ($0.42 per share). The company maintains three active clinical trials and is advancing its AI-guided precision-oncology drug candidates.

Starlight Therapeutics, a subsidiary of Lantern Pharmaceuticals (NASDAQ: LTRN), announced the formation of its Scientific Advisory Board (SAB) to support the development of STAR-001 for CNS and brain tumors. The inaugural SAB includes four distinguished experts: Dr. Mitchel S. Berger from UCSF, Dr. Lisa M. DeAngelis from Memorial Sloan Kettering, Dr. Stuart Grossman from Johns Hopkins Kimmel Cancer Center, and Dr. John Laterra from Johns Hopkins. These experts will provide strategic guidance for developing treatments targeting both adult and pediatric CNS cancers.

Lantern Pharma (NASDAQ: LTRN), an AI-driven cancer therapy development company, will host its third quarter 2024 operating and financial results webcast on Thursday, November 7, at 4:30 p.m. ET. CEO Panna Sharma and management will discuss Q3 2024 results ending September 30, provide guidance on upcoming milestones, clinical trials, and developments of their proprietary RADR® AI and machine learning platform. A replay will be available on the company's investor relations website after the call.

Lantern Pharma (NASDAQ: LTRN), an AI-focused company developing cancer therapies, announced its participation in the upcoming ThinkEquity Conference. The presentation is scheduled for Wednesday, October 30, 2024, at 10:30 a.m. ET and will take place at the Mandarin Oriental in New York, NY. The company's management will be available for one-on-one meetings during the conference. The event can be accessed through provided webcast and registration links, offering investors an opportunity to learn about Lantern's innovative approach to oncology drug discovery and development.