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Lantern Pharma Inc. (LTRN) leverages artificial intelligence and precision medicine to revolutionize oncology drug development. This news hub provides investors and researchers with timely updates on the company's progress in transforming cancer treatment through biomarker-driven approaches.
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Lantern Pharma (NASDAQ:LTRN) announced that its subsidiary, Starlight Therapeutics, received FDA clearance for its IND application to conduct a Phase Ib/2a clinical trial evaluating STAR-001 in combination with spironolactone for glioblastoma multiforme (GBM) patients. The trial will assess safety, tolerability, and preliminary efficacy in recurrent GBM patients.
STAR-001 is a brain-penetrant DNA-damaging agent that has received both FDA Orphan Drug and Fast Track Designations. The combination therapy leverages synthetic lethality, targeting approximately 60% of GBM cells that overexpress PTGR1. The global market opportunity for GBM treatment is estimated at $3-5 billion annually.
The company plans to commence the trial in late 2025 or early 2026, pending additional funding. A separate Phase 1a trial determining safety and dosing is expected to complete enrollment this quarter.
Lantern Pharma (NASDAQ:LTRN) has publicly released predictBBB.ai™, a groundbreaking AI module for predicting blood-brain barrier (BBB) permeability with 94% accuracy, 95% sensitivity, and 89% specificity. The platform leverages billions of data points across millions of compounds to address a critical pharmaceutical challenge, as only 2-6% of small-molecule drugs successfully cross the blood-brain barrier.
The technology currently holds five of the top eleven positions on the Therapeutic Data Commons Leaderboard. The BBB technologies market is projected to grow from $1.4 billion in 2023 to $9.85 billion by 2032. Lantern is implementing a freemium business model to accelerate adoption while creating pathways for strategic collaborations across the pharmaceutical ecosystem.
Lantern Pharma (NASDAQ: LTRN) has successfully completed targeted enrollment for its Phase 2 HARMONIC™ clinical trial in Japan, enrolling 10 patients ahead of schedule across five clinical sites, including the National Cancer Center Japan. The trial evaluates LP-300 in combination with carboplatin and pemetrexed for never-smoker patients with non-small cell lung cancer (NSCLC).
The trial has shown promising initial results, with an 86% clinical benefit rate and 43% objective response rate among the first seven U.S. patients, including one patient achieving a durable complete response lasting nearly two years. The global trial aims to enroll approximately 90 patients across multiple regions, targeting a market opportunity estimated at over $4 billion annually.
Japan represents a strategically important region with 35-40% of NSCLC cases occurring in never-smokers, compared to 15% in Western populations. Additional clinical data from both Asian and U.S. patient cohorts is expected by the end of Q3 2025.
Lantern Pharma (NASDAQ: LTRN) has appointed Dr. Lee T. Schalop to its Board of Directors. Dr. Schalop brings over 20 years of combined experience in biotechnology leadership and financial markets, with expertise in precision neurooncology and clinical development.
Dr. Schalop notably co-founded Oncoceutics, Inc., which was successfully sold to Chimerix Inc. for $450 million in 2021. At Oncoceutics, he served in various senior roles including CEO, and the company later became part of Jazz Pharmaceuticals in a $935 million acquisition in 2025.
This strategic appointment aligns with Lantern Pharma's focus on AI-driven oncology drug development and its CNS-focused pipeline through subsidiary Starlight Therapeutics. Dr. Schalop's expertise in clinical development and strategic transactions is expected to support the company's mission in transforming cancer drug discovery through AI and machine learning.
Lantern Pharma (NASDAQ:LTRN) has reported a groundbreaking complete metabolic response in a heavily pre-treated lymphoma patient using LP-284 in its Phase 1 clinical trial. The 41-year-old patient, who had previously failed three aggressive treatment regimens including R-CHOP chemotherapy, CAR-T therapy, and bispecific antibody therapy, achieved complete response after just two 28-day cycles of LP-284.
The AI-guided drug development, powered by Lantern's RADR® platform, enabled the company to advance LP-284 from concept to clinical milestone in under three years at approximately $3 million. This success positions LP-284 to potentially address a critical need in the $4 billion global blood cancer market, particularly for DLBCL, which affects approximately 200,000 patients globally each year.
Lantern Pharma (NASDAQ:LTRN) has received a notice of allowance from the European Patent Office for LP-284, its AI-developed cancer therapy. The patent, extending through early 2039, covers the composition of matter for LP-284, which targets B-cell lymphomas and other B-cell malignancies.
LP-284, developed using Lantern's RADR® AI platform, is currently in Phase 1 clinical trials with potential completion in late 2025. The drug has received Orphan Drug Designations from the FDA for both mantle cell lymphoma (MCL) and high-grade B-cell lymphomas (HGBL). The therapy addresses a $4 billion annual market for blood cancers.
The development of LP-284 was notably efficient, achieving clinical trial readiness in under three years at a cost of $1.5 to $2.0 million. The patent complements existing protections in the US, Japan, India, and Mexico, with pending applications in other key markets.
Lantern Pharma (NASDAQ:LTRN) has launched an innovative AI-powered module within its RADR® platform to predict the effectiveness of combination cancer treatments. The module, trained on 221 clinical trials, focuses on DNA damaging agents (DDAs) and DNA repair inhibitors (DDRis), targeting a $50+ billion market growing at 8.5% annually through 2030.
The AI system has already demonstrated success by guiding an FDA-cleared Phase 1B/2 trial design combining LP-184 with olaparib for triple-negative breast cancer. The platform analyzes genomic, transcriptomic, and clinical data to predict drug synergies and identify optimal patient populations, potentially reducing development timelines and costs by one-third compared to traditional methods.
Key findings include an 80% positive outcome rate in non-PARP DDRi combinations, particularly with WEE1 inhibitors and platinum agents in TP53-mutated cancers.