Welcome to our dedicated page for Lantern Pharma news (Ticker: LTRN), a resource for investors and traders seeking the latest updates and insights on Lantern Pharma stock.
Lantern Pharma Inc. (Symbol: LTRN) is at the forefront of innovation in the realm of cancer treatment, striving to deliver the most effective therapies to patients who are poised to benefit the most. The company employs a pioneering precision medicine approach to cancer treatment, leveraging biomarker-based genetic screening to identify and treat patients who would derive the greatest benefit from their drugs. This method not only reduces the cost of drug development but also expedites the time to market.
Lantern Pharma's core business revolves around its proprietary artificial intelligence (AI) and machine learning (ML) platform, RADR. The RADR platform assimilates oncology-focused data points and utilizes advanced ML algorithms to address complex, billion-dollar challenges in cancer drug development. This innovative platform has significantly accelerated the company's growing pipeline of precision therapies, with input from world-class scientific advisors and collaborators.
In addition to its in-house development, Lantern Pharma adopts a strategic approach by acquiring or partnering with promising drug and diagnostic companies. This strategy is aimed at advancing personalized medicine programs for cancer patients, thus broadening the company's impact in the oncology space.
With a commitment to transforming the cost, pace, and timeline of oncology drug discovery and development, Lantern Pharma continues to make strides in the development of precision therapies. The company's recent achievements and ongoing projects underscore its potential to revolutionize cancer treatment and deliver significant value to both patients and stakeholders.
Lantern Pharma (NASDAQ: LTRN) has received three rare pediatric disease designations (RPDD) from the FDA for its drug candidate LP-184 in malignant rhabdoid tumors, rhabdomyosarcoma, and hepatoblastoma. This brings the total RPDDs for LP-184 to four, including a previous designation for atypical teratoid rhabdoid tumors. The efficacy of LP-184 was demonstrated through tumor regression and extended event-free survival in models developed by the NCI-supported Pediatric Preclinical Testing Program.
RPDDs can lead to Priority Review Vouchers upon FDA marketing approval, which can expedite future drug reviews or be sold for significant sums. LP-184 is currently in a Phase 1A clinical trial enrolling 50-60 patients across various solid tumors. Lantern Pharma aims to use AI and data-driven approaches to revolutionize cancer drug development, potentially reducing costs and accelerating timelines for new therapies.
Lantern Pharma (NASDAQ: LTRN) reported Q2 2024 financial results and business updates. Key highlights include:
1. Preliminary data from LP-300 Harmonic™ Trial showed 86% clinical benefit rate in initial 7-patient cohort.
2. Phase 1 trials for LP-184 and LP-284 progressing with no dose-limiting toxicities.
3. Launched AI-driven collaboration with Oregon Therapeutics for XCE853 development.
4. Starlight Therapeutics advancing Phase 1B/2 trial for STAR-001 in recurrent GBM.
5. Q2 2024 financials: $33.3M cash position, $3.9M R&D expenses, $1.5M G&A expenses, $4.96M net loss ($0.46 per share).
6. RADR® AI platform continues to expand in size and capabilities.
Lantern Pharma (NASDAQ: LTRN) announced promising preclinical results for LP-184, demonstrating synergy with checkpoint inhibitors and the ability to resensitize tumors non-responsive to Anti-PD1 therapies. Key findings include:
1. LP-184 potentiates anti-PD1 response in a mouse model of triple negative breast cancer (TNBC) resistant to immunotherapy.
2. It can transform 'cold' tumors into 'hot' tumors by modulating T cell activity and inducing replication stress response defects.
3. LP-184 reshapes the tumor microenvironment by reducing M2 macrophages associated with tumor drug resistance.
4. Combined with anti-PD1, LP-184 showed greater anti-tumor response than monotherapies in mouse TNBC tumors.
LP-184 is currently in a Phase 1 trial for advanced recurrent solid tumors. This research supports Lantern's AI-driven hypothesis on LP-184's potential to synergize with PD1 and PDL1 drugs, potentially improving cancer treatment outcomes.
Lantern Pharma (NASDAQ: LTRN) announced positive preliminary results from the Phase 2 HARMONIC™ clinical trial for LP-300 in never smokers with advanced non-small cell lung cancer (NSCLC). The initial patient cohort showed an 86% clinical benefit rate and a 43% objective response rate. Key findings include:
- 6 out of 7 patients experienced clinical benefit
- 3 patients showed partial responses with an average 51% tumor size reduction
- 3 patients had stable disease with an average 13% tumor size reduction
- No additional safety concerns or dose-limiting toxicities were observed
- Efficacy was seen regardless of prior treatments or tumor characteristics
The trial is now in the randomization and expansion phase, potentially enrolling up to 80 additional patients. Lantern Pharma aims to address the growing global need for therapies specifically approved for never-smoker NSCLC patients.
Lantern Pharma (NASDAQ: LTRN), an AI-driven cancer therapy company, has announced its second quarter 2024 operating and financial results webcast scheduled for August 8, 2024, at 4:30 p.m. ET. The company, which utilizes its proprietary RADR® AI and machine learning platform to develop targeted cancer therapies, will discuss Q2 results ending June 30, 2024. CEO Panna Sharma and other management team members will lead the call, providing insights on upcoming milestones, clinical trials, and AI platform developments. Interested parties can register for the webcast through the provided Zoom link, with a replay available on the company's investor relations website post-call.
Lantern Pharma (NASDAQ: LTRN) has achieved a milestone in developing a qRT-PCR-based diagnostic for its drug candidate, LP-184. This diagnostic quantifies PTGR1 RNA in tumor samples, helping identify patients likely to respond to LP-184 across various solid tumors. Successful confirmation of PTGR1 as a important biomarker paves the way for further assay validation and eventual use in later-stage clinical trials. Studies have shown that incorporating biomarkers like PTGR1 can significantly enhance clinical trial success rates. LP-184, aimed at treating malignant gliomas, pancreatic cancer, and ATRT, holds both Orphan Drug and Rare Pediatric Disease designations from the FDA.
Lantern Pharma has received a Certificate of Patent from the Japanese Patent Office (JPO) for its drug candidate LP-284, developed using the company's RADR® AI platform. LP-284, aimed at treating relapsed or refractory non-Hodgkin’s lymphoma and certain genomically defined sarcomas, is currently in a Phase 1 clinical trial. Japan is the third country to issue this patent, following the US in April 2023, with anticipated patents in Europe, China, and other countries. Lantern estimates LP-284 could benefit 40,000 to 80,000 blood cancer patients annually, potentially capturing a $4 billion global market. The drug has also received Orphan Drug Designation from the U.S. FDA for the treatment of high-grade B-cell lymphomas and mantle cell lymphoma.
Lantern Pharma Inc. (NASDAQ: LTRN) released its first-quarter 2024 financial results and operational highlights. The company reported progress in multiple clinical trials, obtaining regulatory allowance for the Harmonic™ clinical trial in Japan and Taiwan, and advancing AI-guided drug candidates LP-184 and LP-284. The global market potential for LP-184 and LP-284 is estimated to exceed $12 billion USD. Additionally, collaborations with Starlight Therapeutics and Oregon Therapeutics aim to streamline drug development strategies and leverage AI technologies. The company is focused on precision oncology and the development of high-impact drug candidates, reflecting a positive outlook for future growth.
Oregon Therapeutics and Lantern Pharma are collaborating to optimize the development of the first-in-class drug candidate XCE853, a potent inhibitor of cancer metabolism. The collaboration involves leveraging AI to refine and expand the positioning of XCE853 in new oncology indications, aiming to uncover biomarkers and define potential combination regimens. Lantern Pharma will have equal IP co-ownership and drug development rights in newly discovered biomarkers and indications for XCE853.
Lantern Pharma (NASDAQ: LTRN) will host a webcast on May 9th, 2024, discussing their first quarter 2024 financial results, upcoming milestones, clinical trials, and developments of their AI platform, RADR®. The webcast will be led by Panna Sharma, President and CEO. Register for the webinar here and access the replay on the investor relations section of the Company's website.
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