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Lixte Biotechnology Holdings, Inc. (NASDAQ: LIXT) is a clinical-stage pharmaceutical company focused on cancer drug development, with news flow that reflects both its scientific programs and corporate strategy. Company announcements emphasize its lead compound LB-100, a first-in-class PP2A inhibitor, and its efforts to develop and commercialize cancer therapies targeting solid tumors with unmet medical needs.
News about Lixte often highlights clinical trial progress for LB-100, including proof-of-concept studies in ovarian clear cell carcinoma, metastatic colon cancer, and advanced soft tissue sarcoma. Releases describe collaborations with major institutions such as The University of Texas MD Anderson Cancer Center and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, as well as partnerships with large pharmaceutical companies supplying immunotherapies for combination studies.
Investors following LIXT can also expect updates on strategic transactions and platform expansion. Recent news includes the acquisition of Liora Technologies Europe Ltd., which holds the LiGHT System, an electronically controlled proton therapy platform. This transaction marks Lixte’s entry into the radiotherapy segment of cancer care and is presented as a complement to its LB-100 program.
In addition, Lixte issues releases on capital raises, such as registered direct offerings and private placements, as well as governance and proxy matters described in its definitive proxy statement. For investors and observers, the LIXT news stream provides insight into how the company is advancing LB-100, building a multi-asset oncology platform, managing its capital structure, and executing on its stated mission in oncology.
LIXTE Biotechnology Holdings has initiated its first clinical trial in Spain to evaluate the effectiveness of LB-100 in enhancing the cytotoxic effects of chemotherapy for patients with advanced soft tissue sarcoma (ASTS). Conducted by the Spanish Sarcoma Research Group (GEIS), the trial will commence at Fundación Jiménez Díaz University Hospital in Madrid, with additional sites planned in Valencia and Barcelona.
The Phase 1b trial aims to identify the recommended phase 2 dose and will involve approximately 150 patients randomized to receive either doxorubicin alone or in combination with LB-100. Completion is expected within nine months, paving the way for a subsequent Phase 3 trial.
CEO John S. Kovach expressed optimism about assessing LB-100's potential in improving treatment outcomes for ASTS, emphasizing the critical need for effective therapies.
LIXTE Biotechnology Holdings announced a significant step in its Phase 1b clinical trial for LB-100, a first-in-class protein phosphatase 2A inhibitor, to enhance treatment for extensive stage small cell lung cancer (ED-SCLC).
The Sarah Cannon Research Institute (SCRI) at Tennessee Oncology will now participate in the trial, led by notable oncologists.
John S. Kovach, M.D., emphasized that SCRI's involvement will accelerate patient recruitment, potentially demonstrating LB-100's efficacy in improving treatment outcomes for this aggressive cancer.
LIXTE Biotechnology Holdings has reported new insights on its lead clinical compound, LB-100, demonstrating that deficiency in PP2A can enhance the efficacy of immune checkpoint blockers in cancer treatment. An article published in The Journal of Clinical Investigation outlines a previously unappreciated mechanism linking PP2A to immunosuppression in tumors. CEO John S. Kovach highlighted the potential of LB-100 in immunotherapy, particularly for extensive stage small cell lung cancer, where a clinical trial is currently recruiting participants. This study aims to evaluate LB-100's effectiveness in conjunction with chemotherapy and immune blockers.
LIXTE Biotechnology Holdings announced promising results from preclinical studies using its lead clinical compound LB-100, in combination with a WEE1 kinase inhibitor, showing remarkable effectiveness in killing cancer cells, particularly in tough cases like colorectal, pancreatic, and bile duct carcinomas.
Notably, when cancer cells developed resistance to this therapy, they lost their cancerous properties in animal models. This indicates a novel concept termed “tumor suppressive drug resistance”, suggesting that the resistance can lead to decreased oncogenic capacity. The findings present a potential breakthrough in cancer treatment, emphasizing the unique mechanism of LB-100.
LIXTE Biotechnology Holdings (Nasdaq:LIXT) will present at the Planet MicroCap Showcase: VIRTUAL 2022 investor conference on December 7, 2022, at 3:30 p.m. EST. John S. Kovach, M.D., founder and CEO, will lead the presentation and host a Q&A session.
The conference showcases LIXTE's lead compound, LB-100, a novel protein phosphatase inhibitor with potential in cancer therapy. Interested attendees can access the presentation via this webcast link.
LIXTE Biotechnology Holdings (Nasdaq: LIXT) has gained authorization from the Spanish Agency for Medicines (AEMPS) for a Phase 1b/randomized Phase 2 study of LB-100, its lead compound, combined with doxorubicin for treating advanced soft tissue sarcomas (ASTS). This study aims to determine the efficacy and safety of the combination versus doxorubicin alone, which has been the standard treatment for over 40 years. With up to 170 patients expected, results may enhance treatment outcomes in this niche area, potentially changing existing protocols.
LIXTE Biotechnology Holdings, Inc. has appointed Bas van der Baan as an independent director to its Board of Directors. With over 20 years of experience in biotechnology, particularly in oncology, Mr. van der Baan is expected to enhance LIXTE's strategic direction, particularly in the commercialization of its first-in-class cancer drug, LB-100. This compound targets protein phosphatase 2A and aims to improve patient outcomes in chemotherapy and immunotherapy. LIXTE's novel approach is unique in the market and backed by a strong patent portfolio.
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