Lexaria Bioscien Stock Price, News & Analysis

Lexaria Bioscience (NASDAQ: LEXX) has successfully completed a human clinical study comparing oral DehydraTECH-liraglutide capsules to injectable Saxenda (liraglutide). The study demonstrated a 22.7% overall reduction in adverse events with the oral formulation, including significant decreases in nausea (67%) and gastrointestinal issues (31%). The oral version showed comparable effectiveness in blood glucose, insulin, and weight loss metrics. This breakthrough positions Lexaria to pursue FDA registration through the 505(b)(2) pathway for an oral alternative to injectable liraglutide, which generated $1.8B in revenue for Novo Nordisk in 2024. Notably, Lexaria has now shown reduced adverse events with DehydraTECH versions of all three major GLP-1 drugs: liraglutide, semaglutide, and tirzepatide.

Lexaria Bioscience Corp. (NASDAQ: LEXX) announced its participation in the BIO International Convention, scheduled for June 16-19 in Boston. As the world's largest biotechnology convention, BIO will host over 1,500 exhibitors and 20,000 attendees. Lexaria's CEO and President, along with the Chief Scientific Officer, will attend the event to explore potential partnerships and meet with strategic investors. The company aims to advance discussions regarding its DehydraTECH-enhanced drug product candidates, focusing on weight loss, diabetes, and hypertension treatments. Lexaria is currently scheduling one-on-one meetings with global and regional corporate leaders through the BIO Partnering platform.

Lexaria Bioscience Corp. (NASDAQ: LEXX) has provided an update on its Material Transfer Agreement (MTA) with an unnamed pharmaceutical company (PharmaCO). The company has completed initial pre-clinical pharmacokinetic animal studies evaluating Lexaria's DehydraTECHTM technology, though results will remain confidential. PharmaCO has expressed interest in reviewing pending safety and efficacy data from Lexaria's ongoing independent human study GLP-1-H24-4 in Australia, expected in Q3 2025.

Lexaria is preparing for strategic planning discussions with PharmaCO's human clinical development team regarding potential collaborative human clinical studies. Both parties have agreed to maintain their relationship and keep the temporary exclusive license active until the Australian study data becomes available.

Lexaria Bioscience (NASDAQ: LEXX) has successfully closed a $2 million registered direct offering of common stock with a single institutional investor. The deal was structured at $1.00 per share for 2,000,000 shares, with an option for pre-funded warrants in lieu of shares.

Key highlights of the offering:

• H.C. Wainwright & Co. served as the exclusive placement agent
• The offering was made under an effective S-3 shelf registration
• No additional warrants were issued except for pre-funded warrants
• Net proceeds will support working capital and general corporate purposes

CEO Richard Christopher emphasized the achievement of securing funding in challenging market conditions while minimizing shareholder dilution by avoiding additional warrant issuance. The offering was completed through a shelf registration statement that received SEC approval on January 30, 2025.

Lexaria Bioscience (NASDAQ:LEXX) has secured a definitive agreement with a single institutional investor for a $2 million registered direct offering of common stock. The deal involves the sale of 2,000,000 shares at $1.00 per share.

The offering, expected to close around April 28, 2025, is being facilitated by H.C. Wainwright & Co. as the exclusive placement agent. The company plans to utilize the net proceeds, after deducting placement agent fees and offering expenses, for working capital and general corporate purposes.

The offering is being conducted under Lexaria's effective S-3 shelf registration statement, with a final prospectus supplement and accompanying prospectus to be filed with the SEC.

Lexaria Bioscience (NASDAQ:LEXX) provides a strategic update on GLP-1 industry developments, highlighting its DehydraTECH technology's potential in enhancing oral drug delivery. Recent industry news includes Pfizer's discontinuation of danuglipron development due to liver injury concerns, while Eli Lilly reported positive phase 3 results for orfoglipron, leading to a $100 billion market valuation increase.

The company emphasizes that DehydraTECH has demonstrated enhanced delivery performance with existing oral GLP-1 drugs and shown potential in reducing common side effects that lead to high discontinuation rates (47-64% within 1-2 years). Lexaria is executing its strategy through collaborations, evidenced by a material transfer agreement with PharmaCO announced in September 2024.

The GLP-1 drug sector is expected to generate over $100 billion in annual revenue, with applications expanding across multiple healthcare sectors including cardiovascular disease, chronic kidney disease, obesity, and diabetes.

Lexaria Bioscience (NASDAQ:LEXX) has announced completion of patient enrollment for its Phase 1b clinical study GLP-1-H24-4 in Australia. The 12-week study, investigating safety, diabetes control, and weight loss, has exceeded its initial enrollment targets with 24 patients per study arm versus the original target of 20, across all 5 study arms.

The achievement marks the 'last patient in' (LPI) milestone, with treatment expected to conclude in approximately twelve weeks. Following the treatment phase, the company will proceed with patient sample analyses, data compilation, analysis, and reporting.

Lexaria Bioscience (NASDAQ:LEXX) has initiated dosing in its human study GLP-1-H25-5, comparing oral DehydraTECH-liraglutide to injected Saxenda®-branded liraglutide. The study focuses on pharmacokinetics and safety assessment.

A previous 12-week rodent study showed that oral DehydraTECH-liraglutide achieved:

• 5.88% weight reduction
• 11.54% blood sugar reduction

Earlier GLP-1 PK studies in humans demonstrated that certain oral DehydraTECH formulations showed superior bloodstream delivery and reduced adverse events compared to existing oral semaglutide and injectable tirzepatide products. Currently, liraglutide is only available as an injectable under Saxenda® and Victoza® brands. Despite Teva's generic version launch in June 2024, Novo Nordisk generated $1.0 billion in Saxenda® revenue and $0.8 billion in Victoza® revenue during 2024.

Lexaria Bioscience (NASDAQ:LEXX) announced positive results from Human Study #3 comparing oral DehydraTECH-tirzepatide capsules to injectable Zepbound®. The study showed that oral capsules achieved comparable blood concentration levels to injections by the study's end.

Key findings from the 8-day study of 19 participants revealed that while injected Zepbound® typically peaked on Day 2 and declined, DehydraTECH-tirzepatide levels increased steadily daily. The oral version demonstrated:

• 47% fewer adverse events (20 vs 38)
• 54% reduction in gastrointestinal side effects
• Similar blood glucose reduction and insulin increase by Day 8

The company is now conducting a 12-week Phase 1b registrational study in Australia, starting at 20mg/day for 4 weeks and escalating to 40mg/day for the remaining 8 weeks. This extended study aims to evaluate steady-state blood levels and potentially demonstrate increased delivery and efficacy.