Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on novel cancer therapies that target nuclear export dysregulation. Its lead product, XPOVIO (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor approved in the U.S. in multiple oncology indications and in various indications across more than 50 ex-U.S. territories and countries, according to company statements.
This news page aggregates company-issued updates and market disclosures related to Karyopharm. Readers can follow announcements on XPOVIO commercial performance, such as reported U.S. net product revenue and trends in license and royalty revenue from international partners, as described in the company’s earnings releases. The feed also covers progress in Karyopharm’s clinical pipeline, including multiple myeloma, endometrial cancer, myelofibrosis and diffuse large B-cell lymphoma (DLBCL).
Recent news has highlighted key milestones in late-stage development, including completion of enrollment in the Phase 3 SENTRY trial (XPORT-MF-034) in myelofibrosis and ongoing enrollment in the global Phase 3 XPORT-EC-042 trial in TP53 wild-type advanced or recurrent endometrial cancer. Company releases also describe Phase 2 data in heavily pretreated myelofibrosis patients and the design of additional studies such as SENTRY-2 and XPORT-MM-031 in multiple myeloma.
In addition to clinical and commercial updates, Karyopharm’s news includes financial results, preliminary revenue disclosures, strategic financing transactions involving term loans and convertible notes, and inducement equity awards granted under its inducement stock incentive plan. Investors and observers can use this page to review the company’s own descriptions of its operational progress, financing activities and anticipated clinical catalysts as reported in press releases and referenced in SEC filings.
Karyopharm Therapeutics (Nasdaq: KPTI) announced its upcoming presentations at the 66th American Society of Hematology (ASH) Annual Meeting in San Diego, December 7-10, 2024. The presentations will showcase data on selinexor across multiple studies.
The presentations include two posters: one examining the efficacy and safety of selinexor, pomalidomide, and dexamethasone (SPd) for relapsed/refractory multiple myeloma, and another studying selinexor's effect on ruxolitinib refractory myelofibrosis. Additionally, their partner Antengene will present data comparing weekly selinexor, bortezomib, and dexamethasone versus twice-weekly bortezomib and dexamethasone in Chinese patients with relapsed/refractory multiple myeloma.
Karyopharm Therapeutics reported Q3 2024 financial results with total revenue of $38.8 million, including U.S. XPOVIO net product revenue of $29.5 million. The company narrowed its full-year 2024 guidance, projecting total revenue of $145.0-155.0 million and U.S. XPOVIO net product revenue of $110.0-115.0 million. Following FDA alignment, the Phase 3 SENTRY trial in myelofibrosis will use Absolute Change in Total Symptom Score as a co-primary endpoint, with top-line data expected in 2H 2025. The company reported a net loss of $32.1 million for Q3 2024 and had cash reserves of $133.9 million as of September 30, 2024.
Karyopharm Therapeutics (Nasdaq: KPTI) has granted 10,500 restricted stock units (RSUs) to three newly-hired employees as of October 31, 2024. The RSUs were awarded under the company's 2022 Inducement Stock Incentive Plan and will vest over three years, with 33 1/3% vesting annually. The grants serve as employment inducements in compliance with Nasdaq Listing Rule 5635(c)(4). The RSUs include accelerated vesting provisions in case of employment termination following a change in control event.
Karyopharm Therapeutics (Nasdaq: KPTI), a commercial-stage pharmaceutical company focused on novel cancer therapies, has scheduled its third quarter 2024 financial results announcement for Tuesday, November 5, 2024. The management team will host a conference call and audio webcast at 8:00 a.m. ET on the same day. The presentation will include financial results and company updates, with dial-in numbers provided for both local and international participants. A live webcast with slides will be available on the company's investor website, with an archived version accessible approximately two hours after the event.
Karyopharm Therapeutics (Nasdaq: KPTI) announced a change in co-primary endpoint for its Phase 3 SENTRY Trial in myelofibrosis, replacing TSS50 with Absolute Total Symptom Score (Abs-TSS) following FDA feedback. The trial's sample size will increase to approximately 350 patients, with top-line data expected in 2H 2025.
Phase 1 trial data showed promising results with 79% of patients achieving SVR35 and an average Abs-TSS improvement of 18.5 points at week 24 when combining selinexor with ruxolitinib, compared to historical data showing less than 50% SVR35 achievement with JAK inhibitor monotherapy.
Karyopharm Therapeutics (Nasdaq: KPTI) has announced a conference call and webcast scheduled for October 31, 2024, at 8:00 a.m. ET. The event will feature leading myelofibrosis experts Dr. Raajit Rampal from Memorial Sloan Kettering Cancer Center and Dr. John Mascarenhas from Mount Sinai. They will provide a favorable study design update on the company's pivotal Phase 3 SENTRY study in JAKi naive myelofibrosis.
The conference call will be accessible via phone at (800) 836-8184 (local) or (646) 357-8785 (international). A live webcast with slides will be available on the company's investor website, with an archived version available approximately two hours after the event.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company focusing on novel cancer therapies, has announced the granting of 17,000 restricted stock units (RSUs) to three newly-hired employees. These RSU awards were granted on September 30, 2024, under the company's 2022 Inducement Stock Incentive Plan, in compliance with Nasdaq Listing Rule 5635(c)(4).
The RSU awards will vest over a three-year period, with 33 1/3% of the shares vesting on each anniversary of the Grant Date, subject to continued employment. In the event of a "change in control event" followed by termination for "good reason" or without "cause" within one year, the RSUs will become immediately exercisable in full.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company focusing on novel cancer therapies, has announced the granting of 22,050 restricted stock units (RSUs) to five newly-hired employees. These RSU awards, granted on August 31, 2024, are part of the company's 2022 Inducement Stock Incentive Plan and comply with Nasdaq Listing Rule 5635(c)(4).
The RSUs will vest over three years, with 33 1/3% vesting on each anniversary of the grant date, subject to continued employment. In case of a 'change in control event' followed by termination under specific conditions within a year, the RSUs will become fully exercisable.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company specializing in novel cancer therapies, has announced its participation in two upcoming investor conferences in September 2024:
- H.C. Wainwright 26th Annual Global Investment Conference on September 10, featuring a podium presentation at 9:00 a.m. ET
- Baird 2024 Global Healthcare Conference on September 11, with a fireside chat at 10:50 a.m. ET
Live webcasts and slides will be available on the company's website. Karyopharm is known for its oral compound XPOVIO® (selinexor), an XPO1 inhibitor approved in the U.S. for three oncology indications and in other countries as NEXPOVIO®. The company focuses on high unmet need cancers, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) reported financial results for Q2 2024, achieving total revenue of $42.8 million and U.S. XPOVIO® net product revenue of $28.0 million. The company highlighted:
1. Updated clinical results from the SIENDO study showing promising PFS in endometrial cancer subgroups.
2. Completion of refinancing transactions extending debt maturities to 2028 and 2029.
3. Raised lower end of 2024 revenue guidance to $145.0-$160.0 million.
4. Lowered 2024 R&D and SG&A expense guidance to $250.0-$265.0 million.
5. Reported net income of $23.8 million for Q2 2024.
6. Cash position of $152.5 million as of June 30, 2024.