Ipsen Provides Update On Phase III CONTACT-01 Trial Evaluating Cabozantinib in Combination With Atezolizumab in Patients With Metastatic Non-small Cell Lung Cancer Previously Treated With Immunotherapy and Chemotherapy
Ipsen announced that the CONTACT-01 study, evaluating Cabometyx® (cabozantinib) with atezolizumab for treating non-small cell lung cancer (NSCLC), did not achieve its primary endpoint of overall survival. The trial involved 366 patients who previously received anti-PD-1 treatment and chemotherapy. Despite the disappointing results, the safety profile of the treatment was consistent with known safety profiles and no new safety signals were identified. Detailed findings will be presented at a future medical meeting.
- The safety profile of cabozantinib in combination with atezolizumab was consistent with known profiles, indicating no new safety concerns.
- The CONTACT-01 study failed to meet its primary endpoint of overall survival in patients with NSCLC.
- The trial did not meet its primary endpoint of overall survival (OS)
- The safety profile of the combination of cabozantinib and atezolizumab was consistent with the known safety profiles for each single agent
- The clinical trial results will be presented at a future medical meeting
Ipsen (Euronext: IPN; ADR: IPSEY) announced today that the CONTACT-01 study did not meet its primary endpoint of overall survival (OS) at the final analysis. CONTACT-01 is a phase III clinical trial evaluating Cabometyx® (cabozantinib) in combination with atezolizumab (Tecentriq®) versus docetaxel in patients with unmutated metastatic non-small cell lung cancer (NSCLC) who experienced disease progression on or after treatment with an immune checkpoint inhibitor and platinum-containing chemotherapy.
The safety profile of the combination of cabozantinib and atezolizumab observed in the trial was consistent with the known safety profiles for each single agent, and no new safety signals were identified. Detailed findings from CONTACT-01 will be submitted for presentation at a future medical meeting.
ENDS
About CONTACT-01
CONTACT-01 is a global, multicenter, randomized, phase 3, open-label study that enrolled 366 patients who were randomized 1:1 to the experimental arm of cabozantinib in combination with atezolizumab and the control arm of docetaxel. The study enrolled patients with both squamous and non-squamous NSCLC who progressed during or following anti-PD-1/PD-L1 therapy administered either concurrently or sequentially with chemotherapy. The primary endpoint of the trial was overall survival. Secondary endpoints included progression-free survival, objective response rate and duration of response. Results from cohort 7 of the phase 1b COSMIC-021 trial informed the CONTACT-01 trial design. CONTACT-01 was sponsored by Roche and co-funded by Exelixis. Both
About CABOMETYX® (cabozantinib)
Cabometyx is a multi-targeted tyrosine kinase inhibitor (TKI) with targets including vascular endothelial growth factor receptor (VEGFR), c-MET and the TAM receptor family, which block the growth of cancer.
Exelixis granted Ipsen exclusive rights for the commercialization and further clinical development of Cabometyx outside of the
In over 60 countries outside of
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Monotherapy for advanced renal cell carcinoma:
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- Monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy
- Monotherapy for the treatment of hepatocellular carcinoma (HCC) in adults who have previously been treated with sorafenib.
About Ipsen
Ipsen is a global, mid-sized biopharmaceutical company focused on transformative medicines in Oncology, Rare Disease and Neuroscience. With Specialty Care sales of
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