Marengo Therapeutics Announces First Drug Candidate Nomination from Oncology Collaboration with Ipsen
- Marengo Therapeutics and Ipsen partnership aims to develop T cell activator molecule for solid tumor treatment
- Ipsen nominates first clinical drug candidate from the collaboration
- Marengo receives milestone payment for pre-defined pre-clinical milestone
- Marengo and Ipsen plan to advance the program through IND-enabling studies and into clinical development
- Potential of STAR TCR Vb T cell activator platform to deliver precision T cell bispecific antibodies for refractory solid tumors
- None.
- A Novel TCR Vβ bifunctional selective T cell activator molecule for solid tumor treatment
- Marengo to receive an associated milestone payment and eligible for additional future milestone payments, and tiered royalties
This clinical candidate reflects a productive collaboration since the strategic partnership was signed in August 2022. Marengo and Ipsen plan to advance the program through IND-enabling studies and into clinical development. This nomination represents the first of two selective T cell activation repertoire (STAR) T cell bi-functional activator programs that Marengo and Ipsen will advance as part of the collaboration.
"The DC nomination is a testament to our close partnership with Ipsen and to the expertise and dedication of Marengo's R&D team," said Zhen Su, M.D., MBA, Chief Executive Officer of Marengo. "It underscores the potential of our STAR TCR Vb T cell activator platform to deliver a range of first-in-class precision T cell bispecific antibodies for the treatment of refractory solid tumors. We look forward to the next phase of the collaboration as we work to advance treatment options for patients living with cancer."
Under the terms of the agreement, Marengo will receive a milestone payment for this pre-defined pre-clinical milestone. Marengo is leading the research and preclinical development efforts while Ipsen will assume responsibilities for regulatory submissions, clinical development and commercialization.
About Marengo Therapeutics
Marengo Therapeutics, Inc, a clinical-stage biotech company, develops novel TCR-targeting antibodies that selectively modulate common and disease-specific T cell subsets of the germline TCR repertoire to provide lifelong protection against cancer and other diseases. With a passionate team of dedicated scientists experienced in immunology and oncology, Marengo's proprietary Selective T Cell Activation Repertoire (STAR) platform leverages an extensive biological understanding of T cell function and receptor signaling to create a world in which everyone's immune system can defeat cancer. To learn more, visit marengotx.com.
About STAR™ Platform
Marengo's STAR™ Platform is a multi-specific antibody-fusion platform derived from Marengo's proprietary library of antibodies targeting germline-encoded variable (V)β regions of the TCR fused to different T cell co-stimulatory moieties. Combining a novel non-clonal mode of TCR activation with a T cell co-stimulator in the same molecule, promotes a distinct mechanism of action that promotes durable anti-tumor Vβ T cell responses.
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SOURCE Marengo Therapeutics
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