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Immatics N.V. (NASDAQ: IMTX) is a pioneering clinical-stage biopharmaceutical company dedicated to the discovery and development of innovative T-cell redirecting immunotherapies for cancer treatment. Headquartered in both Germany and Switzerland, Immatics harnesses cutting-edge biotechnology to create transformative therapies aimed at combating various forms of cancer.
The company's core product candidates include adoptive cell therapies and bispecific TCR molecules. These therapies are designed to target tumor-specific antigens identified through Immatics' proprietary and world-leading XPRESIDENT® technology platform. This platform enables the precise identification and validation of tumor targets, ensuring the development of highly specific and effective cancer treatments.
Immatics is structured around two proprietary technology platforms and actively manages eight proprietary development programs, with two programs already in clinical trials as of 2017. The company's robust research pipeline covers more than 100 targets across 20 major solid and liquid tumors, with approximately 80% of these targets being novel discoveries.
Recent financial successes underscore Immatics' growth and potential; the company has raised over $230 million in cash through five financing rounds. This substantial funding supports their mission to advance T-cell redirecting immunotherapies and bring new hope to cancer patients worldwide.
Immatics collaborates with numerous third-party pharmaceutical and biotechnology companies, forming strategic partnerships to further enhance the development and commercialization of their innovative therapies. The company's commitment to innovation and collaboration positions it as a leader in the biopharmaceutical industry.
For more detailed information, including the latest updates and financial results, visit the Immatics website or follow them on Twitter and Xing.
Immatics (NASDAQ: IMTX) announced positive interim results for its IMA203 TCR-T candidate, showing a 50% objective response rate in a Phase 1a trial targeting PRAME across multiple solid tumors. The company is set to initiate multiple Phase 1b expansion cohorts in Q2 2022, including monotherapy and combination therapies. Additionally, a global licensing agreement with Bristol Myers Squibb provides Immatics with a $150 million upfront payment and up to $770 million in potential milestone payments. As of December 31, 2021, cash reserves totaled $164 million, ensuring operational funding through 2024.
Bristol Myers Squibb (NYSE:BMY) reported Q4 revenues of $12.0 billion, an 8% increase driven by robust sales of Eliquis and immuno-oncology products. Full-year revenues reached $46.4 billion, up 9%. Q4 earnings per share (EPS) stood at $1.07 (GAAP) and $1.83 (non-GAAP), with annual EPS at $3.12 and $7.51 respectively. The company announced a $15 billion share repurchase authorization and provided 2022 guidance, predicting $47 billion in revenues. The outlook includes expected growth from new products and a reduction in operating expenses.
Bristol Myers Squibb (NYSE:BMY) has reported fourth quarter revenues of $12.0 billion, marking an 8% increase year-over-year, and full-year revenues of $46.4 billion. The fourth quarter earnings per share (EPS) stand at $1.07 (GAAP) and $1.83 (non-GAAP), with full-year EPS at $3.12 and $7.51 respectively, reflecting a 17% growth in non-GAAP EPS. The company has authorized a $15 billion share repurchase initiative and announced a $5 billion accelerated share repurchase agreement for Q1 2022. Guidance for 2022 includes projected revenues of approximately $47 billion.
Immatics has secured a significant collaboration with Bristol Myers Squibb to develop the TCR bispecific candidate IMA401. The agreement entails an upfront payment of $150 million, with potential milestone payments totaling up to $770 million and double-digit royalties on net sales. IMA401 targets the MAGEA4/8 antigen prevalent in solid tumors and has demonstrated promising anti-tumor activity in preclinical studies. Clinical trials are expected to start in the first half of 2022.
Bristol Myers Squibb (BMY) has secured a global exclusive license to Immatics' (IMTX) TCR bispecific program IMA401. This strategic collaboration involves an upfront payment of
Immatics reported a positive update on its ACTengine® IMA203 trial targeting PRAME, showcasing a 94% disease control rate in evaluable patients and 50% achieving objective responses. The company plans to initiate three expansion cohorts for IMA203, including monotherapy and combinations with checkpoint inhibitors. Financially, cash reserves stand at $200.6 million as of September 30, 2021, though the company recorded a net loss of €27.2 million for Q3 2021, a decrease from a significant loss in Q3 2020. This news positions Immatics for potential growth in immunotherapy.
Immatics N.V. (NASDAQ: IMTX) has reported interim clinical data from its ongoing Phase 1a trial of ACTengine® IMA203, showing a 50% objective response rate (8/16 patients) across various solid cancers. Notably, 62% responded to higher dose levels. The therapy was well-tolerated, with manageable adverse events and no significant toxicities. Key findings indicate promising tumor infiltration and T cell persistence. The data will be presented at the SITC Annual Meeting on November 13, 2021, highlighting the potential of IMA203 in treating advanced solid cancers.
Immatics N.V. (NASDAQ: IMTX) has announced updates on its clinical trial ACTengine® IMA203, which will be presented at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) from November 10-14, 2021. The oral presentation on November 13 will cover safety and anti-tumor activity in advanced solid cancers, while a preclinical data update on CD8 TCR-T will be presented as a poster on November 12. These updates reflect Immatics’ commitment to enhancing cancer immunotherapy.
Immatics (NASDAQ: IMTX) reported its financial results for Q2 2021, revealing a net loss of €23.8 million ($28.3 million), up from €21.3 million ($25.3 million) in Q2 2020. The company's cash and cash equivalents stood at €192.8 million ($229.1 million) as of June 30, 2021. Patient recruitment for the ACTengine® programs continues positively, with 27 patients treated by the end of July. Immatics is advancing its TCR Bispecifics pipeline, anticipating the submission of a Clinical Trial Application for IMA401 in Q4 2021. Key upcoming data releases are expected in the second half of 2021.
BioCopy AG has partnered with Immatics N.V. (NASDAQ: IMTX) to enhance T cell receptor (TCR) characterization, crucial in cancer immunotherapy. The collaboration aims to innovate high-throughput screening for TCR-peptide-HLA interactions, supporting the development of TCR-based therapies. BioCopy's patented technology can analyze over 5,000 interactions simultaneously, potentially expediting pre-clinical safety assessments. Rainer Böhm of BioCopy emphasized their unique platform addressing oncology and infectious diseases, while Immatics plans to integrate this into its XCEPTOR® platform for targeted cancer therapies.
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