Welcome to our dedicated page for Immatics N.V news (Ticker: IMTX), a resource for investors and traders seeking the latest updates and insights on Immatics N.V stock.
Immatics N.V. (IMTX) is a clinical-stage biopharmaceutical leader developing T-cell redirecting immunotherapies for cancer treatment. This news hub provides investors and researchers with timely updates on groundbreaking therapies targeting solid and liquid tumors through proprietary platforms like Xpresient® and TCER® molecules.
Access consolidated coverage of press releases, clinical trial milestones, and strategic partnerships. Track developments in adoptive cell therapies and bispecific TCR molecules designed to enhance precision oncology outcomes. Our repository ensures you never miss critical updates about FDA interactions, collaborative research advancements, or pipeline expansions.
Key content categories include clinical program updates, partnership announcements with major industry players, financial disclosures, and scientific presentations. All materials are vetted for relevance to investment analysis and therapeutic innovation.
Bookmark this page for streamlined access to Immatics' latest achievements in immuno-oncology. Check regularly for authoritative reporting on their mission to redefine cancer treatment through engineered T-cell therapies.
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Immatics N.V. (NASDAQ: IMTX) reported an interim clinical update on ACTengine® IMA203, noting a confirmed objective response rate (cORR) of 50% from Phase 1 trials. The initial results indicate promising efficacy across various solid tumors, including melanoma and ovarian cancer. The company also announced the ongoing treatment of patients with its 2nd generation TCR-T candidate, IMA203CD8, and plans to start a Phase 1/2 trial for TCER® IMA402 in 2023. Financially, Immatics has €309.3 million in cash, projected to fund operations into 2025, and reported a revenue increase to €15.1 million for Q3 2022.
Immatics N.V. has announced a public offering of 10,905,000 ordinary shares priced at $10.09 per share, aiming to raise approximately $110 million in gross proceeds. The offering is expected to close on October 12, 2022, contingent on customary closing conditions. Notable investors include Armistice Capital, Dellora Investments, and Wellington Management. Jefferies and SVB Securities are serving as joint book-running managers for this offering.
Immatics announced promising clinical data for IMA203, a TCR-T therapy targeting PRAME in solid tumors. In a Phase 1 trial, 27 patients were treated, showing a 50% confirmed objective response rate (cORR) at high doses. Specifically, in Phase 1b, 80% of 5 patients experienced ongoing responses across various solid tumors, including melanoma and ovarian cancer. IMA203 demonstrated manageable tolerability with no dose-limiting toxicities. Future data releases and further expansion cohorts are anticipated in 2023, enhancing the outlook for IMA203 and its potential impact on cancer treatments.
Immatics N.V. (NASDAQ: IMTX) announced promising preclinical results for its T cell engaging receptor IMA402, targeting the cancer-associated antigen PRAME, at the ESMO Congress 2022. IMA402 demonstrated enhanced anti-tumor activity in vivo and favorable safety profiles in vitro. With a half-life of over one week, it is expected to allow for effective dosing in patients. The Phase 1/2 clinical trial is set to commence in 2023, with the submission of the Clinical Trial Application planned for Q2 2023, positioning IMA402 as a significant advancement in TCR bispecific therapies.
Immatics announced the initiation of patient treatment in its Phase 1b expansion cohort C for IMA203CD8, a 2nd generation TCR-T monotherapy that targets PRAME in solid tumors. This treatment employs a proprietary CD8αβ co-receptor, enhancing T cell activation. Preclinical results indicated improved anti-tumor activity. The cohort aims to assess IMA203CD8's safety and initial efficacy, with 24 patients expected to be enrolled. Interim data from previous trials showed a 50% objective response rate across various solid tumors. The study is part of a broader multi-cohort strategy.
Immatics N.V. (NASDAQ: IMTX) has initiated patient enrollment in three Phase 1b cohorts for its ACTengine® TCR-T cell therapy targeting PRAME. A multi-program collaboration with Bristol Myers Squibb includes a $60 million upfront payment and potential milestone payments nearing $700 million. The company's financial results for Q2 2022 show a revenue increase to €17.2 million and a net loss reduction to €14.0 million. Cash reserves total €324.4 million, funding operations through the second half of 2024. Expanded collaborations and clinical trials mark continued growth in cancer immunotherapy development.
Bristol Myers Squibb (NYSE:BMY) reported Q2 2022 revenues of $11.9 billion, a 2% year-over-year increase, or 5% when adjusted for foreign exchange. GAAP EPS rose 40% to $0.66, while non-GAAP EPS reached $1.93, mainly impacted by ($0.14) per share from Acquired IPRD charges. 11% revenue growth was noted in in-line products. The company reaffirmed non-GAAP EPS guidance for 2022 while adjusting GAAP EPS guidance. Additionally, they announced plans to acquire Turning Point Therapeutics (NASDAQ:TPTX) for $4.1 billion, expanding their precision oncology portfolio.
Immatics reported significant advancements in its clinical programs, specifically in its IMA203 and IMA401 trials. Patients have commenced treatment in two Phase 1b cohorts, with IND approval for the third cohort. Furthermore, a strategic partnership with Bristol Myers Squibb includes a $60 million upfront payment and potential milestones exceeding $700 million per program. Financially, Immatics reported a net income of €85.7 million for Q1 2022, a notable increase from a loss of €22.8 million in Q1 2021, largely due to collaboration revenue recognition.
Immatics announced a strategic alliance expansion with Bristol Myers Squibb to develop multiple allogeneic TCR-T/CAR-T programs. Immatics will receive an upfront fee of $60 million plus up to $700 million in milestone payments per program, alongside tiered royalties on net sales. This collaboration enhances Immatics’ ACTallo® platform, utilizing gamma delta T cells, and includes an additional TCR target from their 2019 agreement with a $20 million upfront payment. This partnership aims to innovate cancer treatments for solid tumors.
