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HOOKIPA Pharma Inc. (symbol: HOOK) is a clinical-stage biopharmaceutical company dedicated to the development of immunotherapeutics aimed at preventing and treating infectious diseases and cancer. Leveraging its proprietary arenavirus platform, HOOKIPA has created VaxWave® and TheraT®, groundbreaking technologies that reprogram and stimulate the immune system.
VaxWave® is a replication-deficient viral vector, while TheraT® is an attenuated replicating vector. Both technologies are designed to induce strong pathogen-neutralizing antibodies and CD8+ T cells. Remarkably, these vectors can be administered repeatedly without losing efficacy. TheraT® has shown the ability to stimulate CD8+ T cell responses to tumor antigens, achieving frequencies and potencies comparable to or surpassing those seen in adoptive T cell therapy.
HOOKIPA's viral vectors are administered systemically and target dendritic cells in vivo, effectively activating the immune system. This capability is particularly beneficial in the field of immuno-oncology, where it allows for the systemic combating of both primary and metastatic solid tumors.
In recent achievements, HOOKIPA has successfully completed a Phase 1 clinical trial, demonstrating the potential and safety of its innovative approaches. The company continues to focus on advancing its pipeline, which includes the development of an arenavirus-based immunotherapy for KRAS mutant cancer and a neoadjuvant HPV16-specific immunotherapy combined with chemotherapy for HPV16-positive oropharyngeal cancer.
As of December 31, 2023, the company maintains a robust financial position. HOOKIPA remains committed to pioneering immune-based treatments that offer hope for patients with infectious diseases and cancer, positioning itself at the forefront of biopharmaceutical innovation.
HOOKIPA Pharma reported significant advancements in its oncology pipeline, notably with HB-200, which showed a 75% disease control rate in heavily pre-treated head and neck cancer patients. The candidate received FDA Fast Track designation and has advanced to a Phase 2 trial alongside pembrolizumab. Additionally, a collaboration with Gilead triggered a $54 million commitment. HOOKIPA ended 2021 with a pro forma cash position of $156.9 million. Despite a revenue decrease to $18.4 million in 2021 and a net loss of $75.7 million, the company projects funding into H1 2024, supporting ongoing and new programs.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced the promotion of Klaus Orlinger, Ph.D. to Chief Scientific Officer. Since joining in 2012, Orlinger has significantly contributed to the development of HOOKIPA’s arenavirus platform, enhancing its clinical potential in treating infectious diseases and cancers. CEO Joern Aldag highlighted his expertise and leadership role in advancing the company's immunotherapy initiatives. HOOKIPA continues to develop novel treatments targeting various cancers and aims for functional cures for HBV and HIV in collaboration with Gilead.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced it will release its fourth quarter and full year 2021 financial results on March 24, 2022, before market opening. A live conference call and webcast will take place at 8:30 AM ET to discuss these results and provide updates on corporate developments. HOOKIPA focuses on developing novel immunotherapies utilizing its proprietary arenavirus platform, targeting serious diseases including HPV16+ cancers and collaborating with Gilead on HBV and HIV functional cures.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced four poster presentations at the 2022 AACR Annual Meeting, showcasing significant preclinical and clinical data on its arenaviral immunotherapy platform. The research emphasizes strong T cell responses, potential drug combinations, and highlights HB-201 and HB-202's efficacy in treating HPV16+ head and neck cancers. The presented abstracts focus on the broad potential of arenaviral vectors in cancer therapy, indicating their capability to activate tumor-specific CD8+ T cells. HOOKIPA's innovative approach aims to enhance cancer treatment outcomes across various malignancies.
HOOKIPA Pharma Inc. (Nasdaq: HOOK) has announced a public offering of 21.7 million shares of common stock priced at $2.00 each and 15,800 shares of non-voting Series A-1 preferred stock at $2,000 each. The total expected proceeds from this offering are approximately $75 million before expenses. The offering is set to close on March 4, 2022, subject to customary conditions, and underwriters have a 30-day option to purchase an additional 5.625 million shares. Proceeds will support HOOKIPA's immunotherapy development pipeline targeting various cancers and diseases.
HOOKIPA Pharma Inc. (Nasdaq: HOOK) announced plans for an underwritten public offering of its common stock and non-voting Series A convertible preferred stock. The offering allows underwriters a 30-day option to buy up to 15% more shares. The offering is subject to market conditions, and terms may vary. Securities offered are under a shelf registration statement, with details to be filed with the SEC. HOOKIPA focuses on immunotherapeutics for severe diseases, including cancer and viral infections.
HOOKIPA Pharma has announced an amended collaboration with Gilead to develop an arenaviral-based therapy for HIV, progressing through a Phase 1b clinical trial. Gilead is providing financial support, including a $15 million initiation fee and a potential $35 million in equity financing. The partnership aims to enhance Gilead's research in functional cures for HIV and HBV. HOOKIPA previously received a $4 million milestone payment and will receive an additional $5 million equity investment. The agreement underscores HOOKIPA’s innovative platform for immunotherapies targeting significant viral diseases.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced its participation in the virtual 11th Annual SVB Leerink Global Healthcare Conference from February 14-18, 2022, with a corporate presentation scheduled for February 16 at 10:30 AM EST. The presentation will be webcasted, and the replay will be available for 30 days. HOOKIPA focuses on developing novel immunotherapies using its proprietary arenavirus platform to target cancer and other diseases. Its pipeline includes investigational therapeutics for HPV16+ cancers and collaborations aimed at curing HBV and HIV.
HOOKIPA Pharma has initiated the dosing of the first patient with HB-200 and pembrolizumab in a Phase 2 arm of its ongoing Phase 1/2 trial aimed at treating advanced/metastatic HPV16+ head and neck cancer. The FDA has granted Fast Track Designation for HB-200, HB-201, and HB-202/HB-201, recognizing their potential in addressing unmet medical needs. The company's guidance includes further Phase 1 data in mid-2022 and the initiation of a randomized Phase 2 study in 1H 2023. HOOKIPA aims to deliver innovative therapies using its proprietary arenavirus platform.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) will present at the virtual H.C. Wainwright BioConnect Conference from January 10-13, 2022. The presentation, highlighting their innovative immunotherapeutics based on a proprietary arenavirus platform, will be available starting at 7:00 AM EST on January 10. Interested parties can access the webcast via the Investors & Media section of HOOKIPA's website, with a replay accessible for 30 days post-event. HOOKIPA is advancing multiple investigational therapies targeting various cancers and potential cures for HBV and HIV.
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