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HOOKIPA Pharma Inc. (symbol: HOOK) is a clinical-stage biopharmaceutical company dedicated to the development of immunotherapeutics aimed at preventing and treating infectious diseases and cancer. Leveraging its proprietary arenavirus platform, HOOKIPA has created VaxWave® and TheraT®, groundbreaking technologies that reprogram and stimulate the immune system.
VaxWave® is a replication-deficient viral vector, while TheraT® is an attenuated replicating vector. Both technologies are designed to induce strong pathogen-neutralizing antibodies and CD8+ T cells. Remarkably, these vectors can be administered repeatedly without losing efficacy. TheraT® has shown the ability to stimulate CD8+ T cell responses to tumor antigens, achieving frequencies and potencies comparable to or surpassing those seen in adoptive T cell therapy.
HOOKIPA's viral vectors are administered systemically and target dendritic cells in vivo, effectively activating the immune system. This capability is particularly beneficial in the field of immuno-oncology, where it allows for the systemic combating of both primary and metastatic solid tumors.
In recent achievements, HOOKIPA has successfully completed a Phase 1 clinical trial, demonstrating the potential and safety of its innovative approaches. The company continues to focus on advancing its pipeline, which includes the development of an arenavirus-based immunotherapy for KRAS mutant cancer and a neoadjuvant HPV16-specific immunotherapy combined with chemotherapy for HPV16-positive oropharyngeal cancer.
As of December 31, 2023, the company maintains a robust financial position. HOOKIPA remains committed to pioneering immune-based treatments that offer hope for patients with infectious diseases and cancer, positioning itself at the forefront of biopharmaceutical innovation.
HOOKIPA Pharma has reported positive Phase 1 results for its HB-200 program targeting advanced HPV16+ head and neck cancer. The new alternating 2-vector therapy (HB-202/HB-201) demonstrated superior immune and tumor responses compared to the single-vector (HB-201), achieving an 80% disease control rate. Moving forward, HOOKIPA plans to advance to Phase 2 trials, which will explore the new therapy in conjunction with pembrolizumab and also as a standalone treatment in a post-standard care setting. These findings reflect HOOKIPA's commitment to innovative immunotherapy solutions in oncology.
HOOKIPA Pharma presented promising preclinical data on its arenaviral therapeutic vaccines for HIV at the Keystone Symposium. The findings show that an alternating 2-vector therapy resulted in a significantly stronger immune response compared to single-vector therapy, leading to a substantial reduction in viral load. Conducted in collaboration with Gilead Sciences, this research utilized a simian immunodeficiency virus model to assess immune response. HOOKIPA aims to advance this therapy through a Phase 1b clinical trial, supported by Gilead's funding. These investigational compounds have not been approved for use.
HOOKIPA Pharma announced positive Phase 1 trial results for its HB-200 program targeting HPV16+ head and neck cancers. The data showed that both single-vector HB-201 and the 2-vector HB-202/HB-201 therapies were generally well tolerated and induced tumor-specific T cells, demonstrating anti-tumor activity in patients who had undergone extensive prior treatment. The company plans to present these findings at the ASCO Annual Meeting in June 2022, including the recommended Phase 2 dose for HB-202/HB-201.
HOOKIPA Pharma reported a strong cash position of $142 million as of March 31, 2022, following a capital raise and collaboration with Gilead. The company is advancing its HB-200 program, with Phase 1 data expected mid-year and Phase 2 data expected in late 2022. However, revenue for Q1 2022 was $1.4 million, a decline from $5.3 million in Q1 2021, attributed to lower reimbursements under the Gilead collaboration. The net loss for the quarter was $18 million, slightly higher than the previous year's loss.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced it will release its first quarter 2022 financial results on May 16, 2022, before the market opens. The company specializes in developing novel immunotherapies using its proprietary arenavirus platform to enhance T cell responses against serious diseases. HOOKIPA's pipeline focuses on investigational immunotherapeutics targeting various cancers and aims to develop functional cures for HBV and HIV in partnership with Gilead. No conference call will accompany the earnings release.
HOOKIPA Pharma Inc. (NASDAQ: HOOK) announced its participation in several investor conferences in May 2022. Key events include the BofA Securities 2022 Healthcare Conference from May 10-13, with a fireside chat on May 10 at 8:40am PT; the 2022 RBC Capital Markets Global Healthcare Conference on May 17-18, featuring a chat on May 17 at 4:05pm ET; and the H.C. Wainwright Global Investment Conference from May 23-26, with a chat on May 24 at 2:00pm ET. Webcasts will be available on their website, with archived replays accessible for 30 days.
HOOKIPA Pharma announced the promotion of Christine D. Baker to Chief Operating Officer effective immediately. With over 30 years in the biotech industry, Baker has significantly contributed to HOOKIPA's strategic business collaborations and the development of its proprietary arenavirus platform. Her leadership is expected to bolster HOOKIPA's growth in novel immunotherapies targeting severe diseases. CEO Joern Aldag commended her experience and commitment to advancing the company's innovative pipeline.
HOOKIPA Pharma (NASDAQ: HOOK) has appointed Tim Reilly, Ph.D., to its Board of Directors, effective immediately. Reilly, a veteran in product development and early clinical trials, will enhance HOOKIPA's oncology initiatives, including the Phase 2 HB-200 program for head and neck cancer and preparations for the HB-300 prostate cancer program. His extensive experience includes 18 years at Bristol Myers Squibb, contributing to 12 therapy approvals. HOOKIPA focuses on innovative immunotherapies utilizing its proprietary arenavirus platform to target various cancers.
HOOKIPA Pharma announced positive preclinical data showcasing potent T cell responses and tumor control against cancer using its arenaviral platform. The results, presented at the AACR Annual Meeting, demonstrate effective combination strategies with 4-1BB agonists and adoptive T cell transfers. The company is preparing to file an IND for its HB-300 program targeting prostate cancer. Biomarker data from the ongoing HB-200 study in HPV16+ head and neck cancers indicate a significant induction of tumor antigen-specific T cell responses, further validating the potential of HOOKIPA's innovative immunotherapies.
HOOKIPA Pharma, a clinical-stage biopharmaceutical company, announced participation in investor meetings at the Kempen Life Sciences Conference in Amsterdam on April 20-21, 2022. The company focuses on developing immunotherapies using its proprietary arenavirus platform, targeting various cancers, including HPV16+ and KRAS-mutated cancers. HOOKIPA aims to advance novel treatments that enhance T cell responses and is also working on functional cures for HBV and HIV in collaboration with Gilead.
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