Fractyl Health to Present Compelling Weight Maintenance Data from both Revita® and Rejuva® Platforms at ObesityWeek® 2024

Rhea-AI Summary

Fractyl Health (Nasdaq: GUTS) has announced upcoming presentations of weight maintenance data from its Revita and Rejuva platforms at ObesityWeek 2024, scheduled for November 2-6 in San Antonio, Texas. The company will showcase two key presentations:

1. An oral presentation on islet-targeted GLP-1 receptor agonist gene therapy's effects on fat reduction and metabolism improvement in obese mice, scheduled for November 5.

2. A poster presentation demonstrating how duodenal mucosal resurfacing maintains weight loss in metabolic disease, to be presented during the Welcome Reception on November 3.

These presentations highlight Fractyl Health's commitment to developing innovative treatments for obesity and Type 2 Diabetes by addressing their root causes.

BURLINGTON, Mass., Oct. 28, 2024 (GLOBE NEWSWIRE) -- Fractyl Health, Inc. (Nasdaq: GUTS) (the “Company”), a metabolic therapeutics company focused on pioneering new approaches that treat root causes of obesity and Type 2 Diabetes (T2D), today announced that it will present compelling weight maintenance data from both its Revita and Rejuva platforms at The Obesity Society’s Annual Meeting at ObesityWeek 2024, held from November 2-6, 2024, in San Antonio, Texas.

Oral Presentation

• Title: Islet-Targeted GLP-1 Receptor Agonist Gene Therapy Reduces Fat and Improves Metabolism in Obese Mice
• Presentation Date & Time: Tuesday, November 5, 2024, 10:45 am - 11:00 am (CDT)
• Location: Henry B. Gonzalez Convention Center, Room 007
  

Poster Presentation

• Title: Duodenal Mucosal Resurfacing Durably Maintains Weight Loss in Metabolic Disease
• Presentation Date & Time: Sunday, November 3, 2024, 7:30 pm – 8:30 pm (CDT)
• Location: Henry B. Gonzalez Convention Center Exhibit Hall, Welcome Reception
  

About Fractyl Health 
Fractyl Health is a metabolic therapeutics company focused on pioneering new approaches to the treatment of metabolic diseases, including obesity and T2D. Despite advances in treatment over the last 50 years, obesity and T2D continue to be rapidly growing drivers of morbidity and mortality in the 21st century. Fractyl Health’s goal is to transform metabolic disease treatment from chronic symptomatic management to durable disease-modifying therapies that target the organ-level root causes of disease. Fractyl Health is based in Burlington, MA. For more information, visit www.fractyl.com or https://twitter.com/FractylHealth.  

About Revita
Fractyl Health’s lead product candidate, Revita, is based on the company’s insights surrounding the potential role of the gut in obesity and T2D. Revita is designed to remodel the duodenal lining via hydrothermal ablation (i.e., duodenal mucosal resurfacing) to edit abnormal intestinal nutrient sensing and signaling mechanisms that are a root cause of metabolic disease. Revita has received a CE mark in Europe and, in January 2022, received reimbursement authorization through NUB in Germany for the treatment of T2D. In the United States, Revita is for investigational use only under US law. It has US FDA Breakthrough Device designation in weight maintenance for people with obesity who discontinue GLP-1 based drugs, as well as in insulin-treated T2D. A pivotal study of Revita in weight maintenance for patients with obesity after discontinuation of GLP-1-based drugs, called REMAIN-1, is underway with anticipated data readouts from the open-label study in weight maintenance in the fourth quarter of 2024 and an anticipated mid-point analysis of the REMAIN-1 in the second quarter of 2025. A pivotal study of Revita in patients with T2D who are inadequately controlled on any glucose lowering agent, REVITALIZE-1, is currently enrolling in the United States and Europe. 

About Rejuva
Fractyl Health’s Rejuva platform focuses on developing next-generation adeno-associated virus (AAV)-based, locally delivered gene therapies for the treatment of obesity and T2D. The Rejuva platform is in preclinical development and has not yet been evaluated by regulatory agencies for investigational or commercial use. Rejuva leverages advanced delivery systems and proprietary screening methods to identify and develop metabolically active gene therapy candidates targeting the pancreas. The program aims to transform the management of metabolic diseases by offering novel, disease-modifying therapies that address the underlying root causes of disease.

Contacts 

Corporate Contact 
Lisa Davidson, Chief Financial Officer 
ir@fractyl.com, 781.902.8800

Media Contact 
Jessica Cotrone, Corporate Communications 
jcotrone@fractyl.com, 978.760.5622

Investor Contact
Stephen Jasper, Gilmartin Group
stephen@gilmartinir.com, 619.949.3681

FAQ

What will Fractyl Health (GUTS) present at ObesityWeek 2024?

Fractyl Health will present weight maintenance data from both its Revita and Rejuva platforms, including research on GLP-1 receptor agonist gene therapy and duodenal mucosal resurfacing.

When and where is Fractyl Health's (GUTS) presentation at ObesityWeek 2024?

The presentations will take place at the Henry B. Gonzalez Convention Center in San Antonio, Texas. The poster presentation is on November 3, 2024, and the oral presentation is on November 5, 2024.

What are the two treatment platforms Fractyl Health (GUTS) is presenting data on?

Fractyl Health is presenting data on the Revita platform, which involves duodenal mucosal resurfacing, and the Rejuva platform, which includes islet-targeted GLP-1 receptor agonist gene therapy.

What conditions does Fractyl Health (GUTS) aim to treat with their platforms?

Fractyl Health's platforms are designed to treat the root causes of obesity and Type 2 Diabetes (T2D).