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Generation Bio Co. (Nasdaq: GBIO) is a pioneering biotechnology company dedicated to developing innovative genetic medicines to treat rare and prevalent diseases. The company's mission is to deliver durable and redosable treatments through their groundbreaking platforms. Generation Bio focuses on liver and retina-related diseases and has built a robust pipeline leveraging two main proprietary technologies: the cell-targeted lipid nanoparticle (ctLNP) delivery system and immune-quiet DNA (iqDNA) cargo.
Using the ctLNP delivery system, Generation Bio can selectively target specific tissues and cell types, significantly reducing off-target effects. This system has shown promising results in both mouse models and non-human primates (NHPs), demonstrating effective delivery of genetic materials with minimal immunogenic response. The ctLNP platform is a cornerstone of their collaborative efforts with Moderna, aimed at developing highly specific in vivo delivery systems for T cells and other immune cells.
iqDNA, an optimized variant of the company's closed-ended DNA (ceDNA), stands out for its ability to evade the immune system while maintaining high levels of gene expression. This feature addresses a critical challenge in genetic therapies by allowing for repeated dosing without triggering adverse immune responses. Recent studies have shown that iqDNA has a tolerability profile comparable to chemically modified messenger RNA (mRNA) in both mice and NHPs.
Generation Bio's commitment to innovation is further highlighted by their rapid enzymatic synthesis (RES) manufacturing process. This proprietary method enables scalable and efficient production of their novel DNA constructs, ensuring high purity and consistency. The company believes that RES can support the manufacturing scale required to meet global clinical and commercial demands.
Recent announcements have emphasized the company's progress and strategic collaborations. For instance, their partnership with Moderna focuses on leveraging ctLNPs for targeted delivery of nucleic acid therapies to specific immune cell types. Additionally, Generation Bio's sustained financial health, supported by careful expense management and collaboration incomes, ensures a steady runway into 2026, enabling continued investment in their groundbreaking technologies.
On the business front, Generation Bio is ramping up efforts across their platforms, with ongoing programs targeting hemophilia A, sickle cell disease, and beta-thalassemia. The company is actively presenting their latest data at key industry conferences like the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, showcasing the advanced capabilities of their ctLNP and iqDNA platforms.
For more information about Generation Bio’s revolutionary work in genetic medicine, please visit their website at www.generationbio.com or follow their updates on Twitter (@lifetimegenetx).
Generation Bio Co. (Nasdaq: GBIO) reported a cash position of $301.2 million as of September 30, 2022, expected to fund operations into 2025. The company focuses on developing genetic medicines, particularly for hemophilia A, utilizing its proprietary delivery system. Third quarter R&D expenses totaled $21.2 million, down from $22.0 million the previous year, while G&A expenses rose to $11.5 million, up from $9.7 million. The net loss narrowed to $31.3 million or $0.53 per share, compared to $31.9 million or $0.56 per share a year ago.
Generation Bio Co. (Nasdaq: GBIO) will participate in a fireside chat at the 2022 Jefferies Cell & Genetic Medicine Summit on September 29th at 10:30 a.m. ET in New York. A live webcast will be available on the company's investor website, and a replay will be accessible for 30 days post-event.
Generation Bio focuses on developing genetic medicines for rare and prevalent diseases using its unique platform, which includes closed-ended DNA (ceDNA) technology and a scalable manufacturing process. The aim is to provide durable, redosable treatments for patients worldwide.
Generation Bio Co. (Nasdaq: GBIO) has promoted Phillip Samayoa, Ph.D., to chief strategy officer. Dr. Samayoa, who joined the company in 2017, will lead corporate strategy and business development. His previous experience includes co-founding Generation Bio and roles at Merck and Flagship Pioneering. The company is focused on innovating genetic medicines using non-viral DNA therapeutics and targeted lipid nanoparticle delivery. Generation Bio aims to increase the availability of genetic medicines through its scalable manufacturing processes and unique technology platform.
Generation Bio Co. (Nasdaq: GBIO) reported second quarter 2022 financial results, focusing on advancements in its genetic medicine platform. The company has a cash balance of $312.2 million, projected to fund operations into 2025. Key developments include a new modular manufacturing strategy for its closed-ended DNA (ceDNA) product, enhancing productivity and capital efficiency. The net loss for the quarter increased to $37.9 million, or $0.66 per share, compared to $30.8 million or $0.55 per share in the previous year.
Generation Bio Co. (Nasdaq: GBIO) announced its participation in the virtual 2022 Wedbush PacGrow Healthcare Conference scheduled for August 9th at 9:45 a.m. ET. The event will include a live webcast available on the company’s investor website, with a replay accessible for 30 days post-event. Generation Bio is focused on advancing genetic medicines using its unique non-viral platform, which aims to provide durable, redosable treatments for rare and prevalent diseases, utilizing innovative technologies like closed-ended DNA (ceDNA) and cell-targeted lipid nanoparticles.
Generation Bio (Nasdaq: GBIO) announced the appointment of Dannielle Appelhans to its Board of Directors on July 18, 2022. Appelhans, currently COO of Rubius Therapeutics, brings extensive experience in pharmaceutical strategy and operations, including leadership roles at Novartis. Her expertise is expected to aid Generation Bio as it transitions from research to commercialization. Appelhans expressed enthusiasm about contributing to the company's mission of developing novel genetic medicines for rare diseases.
Generation Bio (Nasdaq: GBIO) is revising its GMP manufacturing strategy to optimize efficiency through enhanced rapid enzymatic synthesis (RES) of closed-ended DNA (ceDNA). The company will sublease its planned GMP facility and adopt a smaller, flexible manufacturing footprint, extending its cash runway into 2025. This shift will not affect production timelines for its ongoing liver, retina, and vaccine programs. The RES process allows for high purity and scalability, enabling the company to produce millions of doses with shorter production cycles.
Generation Bio (Nasdaq: GBIO) will have CEO Geoff McDonough participate in a fireside chat at the 2022 Jefferies Healthcare Conference on June 10th at 11:00 a.m. ET in New York. A live webcast of the event will be accessible on the investor section of the company's website, with a replay available for 30 days afterwards.
The company focuses on innovative genetic medicines for rare and prevalent diseases using a unique DNA construct and delivery system aimed at providing durable treatments.
Generation Bio Co. (Nasdaq: GBIO) reported steady progress in optimizing cell-targeted lipid nanoparticles (ctLNPs) for genetic medicines in liver and retina applications, as well as vaccine development. The company maintains a strong cash position of $337.0 million, projected to fund operations into 2024. In Q1 2022, R&D expenses rose to $25.6 million, while G&A expenses increased to $9.8 million, resulting in a net loss of $35.0 million, or $0.61 per share, compared to a net loss of $25.6 million a year earlier.
Generation Bio Co. (Nasdaq: GBIO) announced that its CEO, Geoff McDonough, will participate in the 21st Annual Needham Virtual Healthcare Conference on April 11th at 11:00 a.m. ET. A live webcast of the event will be available on the company’s investor website, with a replay accessible for 30 days post-event. Generation Bio focuses on developing innovative genetic medicines for rare and prevalent diseases, utilizing its proprietary non-viral genetic medicine platform, which includes unique delivery systems and manufacturing processes aimed at providing durable and scalable treatments.
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