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Generation Bio Co. (Nasdaq: GBIO) is a pioneering biotechnology company dedicated to developing innovative genetic medicines to treat rare and prevalent diseases. The company's mission is to deliver durable and redosable treatments through their groundbreaking platforms. Generation Bio focuses on liver and retina-related diseases and has built a robust pipeline leveraging two main proprietary technologies: the cell-targeted lipid nanoparticle (ctLNP) delivery system and immune-quiet DNA (iqDNA) cargo.
Using the ctLNP delivery system, Generation Bio can selectively target specific tissues and cell types, significantly reducing off-target effects. This system has shown promising results in both mouse models and non-human primates (NHPs), demonstrating effective delivery of genetic materials with minimal immunogenic response. The ctLNP platform is a cornerstone of their collaborative efforts with Moderna, aimed at developing highly specific in vivo delivery systems for T cells and other immune cells.
iqDNA, an optimized variant of the company's closed-ended DNA (ceDNA), stands out for its ability to evade the immune system while maintaining high levels of gene expression. This feature addresses a critical challenge in genetic therapies by allowing for repeated dosing without triggering adverse immune responses. Recent studies have shown that iqDNA has a tolerability profile comparable to chemically modified messenger RNA (mRNA) in both mice and NHPs.
Generation Bio's commitment to innovation is further highlighted by their rapid enzymatic synthesis (RES) manufacturing process. This proprietary method enables scalable and efficient production of their novel DNA constructs, ensuring high purity and consistency. The company believes that RES can support the manufacturing scale required to meet global clinical and commercial demands.
Recent announcements have emphasized the company's progress and strategic collaborations. For instance, their partnership with Moderna focuses on leveraging ctLNPs for targeted delivery of nucleic acid therapies to specific immune cell types. Additionally, Generation Bio's sustained financial health, supported by careful expense management and collaboration incomes, ensures a steady runway into 2026, enabling continued investment in their groundbreaking technologies.
On the business front, Generation Bio is ramping up efforts across their platforms, with ongoing programs targeting hemophilia A, sickle cell disease, and beta-thalassemia. The company is actively presenting their latest data at key industry conferences like the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, showcasing the advanced capabilities of their ctLNP and iqDNA platforms.
For more information about Generation Bio’s revolutionary work in genetic medicine, please visit their website at www.generationbio.com or follow their updates on Twitter (@lifetimegenetx).
Generation Bio (Nasdaq:GBIO) has announced that CEO Geoff McDonough, M.D., will participate in a fireside chat at the 22nd Annual Needham Virtual Healthcare Conference on April 18th at 3:00 p.m. EST. Investors can access a live webcast on the company's investor website, with a replay available for 30 days after the event.
Generation Bio specializes in genetic medicines aimed at providing sustainable, redosable treatments for both rare and common diseases. Their innovative platform utilizes a unique non-viral genetic medicine, featuring closed-ended DNA (ceDNA) and a specialized delivery system known as cell-targeted lipid nanoparticles (ctLNP). This technology is designed to enable long-lasting treatment effects from a single dose and has the potential to significantly scale up production.
Generation Bio Co. (Nasdaq:GBIO) has appointed Yalonda Howze, J.D., as its chief legal officer and secretary. Howze brings nearly two decades of legal experience in biotechnology and life sciences, having previously served at Codiak BioSciences and as a partner at Mintz Levin. CEO Geoff McDonough expressed optimism about her contributions to the company’s ambitious goal of developing transformative genetic medicines for rare and prevalent diseases. Generation Bio focuses on innovative genetic therapies using its proprietary non-viral delivery system, aiming for long-lasting and adjustable treatments.
Moderna and Generation Bio have formed a strategic collaboration to develop novel nucleic acid therapeutics. Moderna has secured an option to license Generation Bio's lipid nanoparticle technology for two immune cell and two liver programs, with the possibility of a third. As part of the deal, Generation Bio will receive a $40 million upfront cash payment, along with a $36 million equity investment from Moderna, which will also fund all research and development activities. The collaboration aims to enhance the delivery of genetic medicines, targeting both immune cells and liver tissues.
On March 21, 2023, Generation Bio (Nasdaq:GBIO) announced its participation in the BMO Biopharma Spotlight Series: Novel Technologies for the Delivery of Genetic Medicines. The virtual event will occur on March 28 at 10:00 a.m. ET.
Generation Bio is focused on developing genetic medicines for rare and prevalent diseases. Their innovative platform features closed-ended DNA (ceDNA), a cell-targeted lipid nanoparticle delivery system (ctLNP), and a proprietary cell-free rapid enzymatic synthesis (RES) process. This technology aims to provide durable, redosable treatments potentially capable of producing hundreds of millions of doses, thus broadening access to genetic therapies globally.
Generation Bio (Nasdaq:GBIO), a biotechnology firm focused on genetic medicines, announced that Geoff McDonough, M.D., the president and CEO, will speak at the Gene Therapy panel during the 43rd Annual Cowen Healthcare Conference. This event is scheduled for March 6th at 10:30 a.m. EST in Boston, MA. A live webcast will be accessible on the company's investor website, with a replay available for 30 days post-event.
Generation Bio aims to provide innovative treatments for rare and prevalent diseases using its proprietary non-viral genetic medicine platform. This includes closed-ended DNA (ceDNA) technology and cell-targeted lipid nanoparticle delivery systems.
Generation Bio Co. (Nasdaq: GBIO) announced strategic priorities for 2023 and reported its 2022 financial results. The company aims to lead in non-viral DNA therapeutics, focusing on optimized delivery systems to enhance drug efficacy. A strong cash balance of $279.1 million is expected to fund operations into 2025. For 2022, the company reported a net loss of $136.6 million or $2.35 per share, with R&D expenses of $96.7 million. Upcoming plans include demonstrating Factor VIII expression in non-human primates and developing novel lipid nanoparticle systems for targeted therapies.
Generation Bio (Nasdaq: GBIO) announced its participation in the 41st Annual J.P. Morgan Healthcare Conference scheduled for January 10, 2023, at 4:30 p.m. PST in San Francisco, CA. The company focuses on innovative genetic medicines targeting rare and prevalent diseases. A live webcast of the presentation will be available on the investor section of their website. Generation Bio's platform features unique technologies designed to enable durable, redosable treatments with large genetic payloads for specific cell types.
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