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About Defence Therapeutics Inc. (DTCFF)
Defence Therapeutics Inc. is a publicly traded, clinical-stage biopharmaceutical company headquartered in Canada, specializing in engineering next-generation vaccines, antibody-drug conjugates (ADCs), and radiopharmaceutical products. At the heart of Defence’s innovation is its proprietary ACCUM® technology platform, a groundbreaking solution designed to optimize intracellular drug delivery by overcoming endosomal entrapment. This enhancement enables precise delivery of therapeutic agents directly to target cells, significantly increasing their efficacy and potency. Defence’s technology is particularly impactful in the fields of oncology and infectious diseases, addressing critical unmet medical needs.
Core Technology: The ACCUM® Platform
The ACCUM® technology is a versatile platform that enhances the delivery and efficacy of biologics, including ADCs, radiopharmaceuticals, vaccines, and protein therapeutics. By addressing the common challenge of endosomal entrapment, ACCUM® ensures that therapeutic agents reach their intended intracellular targets intact, thereby amplifying their therapeutic potential. This innovation is especially valuable in oncology, where precision delivery can improve treatment outcomes while minimizing side effects.
Key Applications and Innovations
- Antibody-Drug Conjugates (ADCs): Defence’s ACCUM® technology enhances the potency of ADCs by ensuring efficient intracellular delivery of cytotoxic agents. This advancement has the potential to reduce dosing requirements and improve patient outcomes.
- Radiopharmaceuticals: The company is developing novel radio-immuno-conjugates that leverage ACCUM® to deliver radioactive isotopes directly to cancer cells. This targeted approach minimizes damage to healthy tissues and enhances therapeutic efficacy.
- Immune-Oncology Vaccines: Defence is pioneering vaccines that utilize ACCUM® to boost immunogenicity, making them more effective against cancers and infectious diseases.
- GLP-1 Analog Development: Defence is exploring the use of ACCUM® to improve the stability and half-life of GLP-1 analogs, addressing challenges in the treatment of obesity and type 2 diabetes.
Business Model and Revenue Streams
Defence Therapeutics operates on a dual business model. It licenses its ACCUM® technology to pharmaceutical and biotech companies, generating immediate revenue while establishing its platform as an industry standard. Concurrently, the company invests in proprietary drug development programs, focusing on oncology and infectious diseases. This balanced approach ensures both near-term profitability and long-term growth.
Market Position and Competitive Landscape
Defence Therapeutics is strategically positioned in the rapidly growing biopharmaceutical and radiopharmaceutical markets. The global cancer immunotherapy market, for instance, is projected to grow significantly, driven by advancements in targeted therapies. Defence’s focus on enhancing the delivery and efficacy of biologics sets it apart from competitors, which include established pharmaceutical companies and emerging biotech firms. Its robust intellectual property portfolio, with patents in multiple jurisdictions, further strengthens its competitive edge.
Commitment to Innovation and Collaboration
Defence is actively involved in collaborative projects with leading research institutions and industry partners. Notable initiatives include its work with Canadian Nuclear Laboratories on radio-immuno-conjugates and its partnership with Orano Support SAS for advanced radiopharmaceutical development. These collaborations underscore Defence’s commitment to leveraging external expertise to accelerate innovation.
Conclusion
With its cutting-edge ACCUM® technology, diversified business model, and strategic focus on oncology and infectious diseases, Defence Therapeutics Inc. is at the forefront of biopharmaceutical innovation. Its dedication to addressing critical medical challenges and its robust intellectual property portfolio position the company as a key player in the global healthcare landscape.
Defence Therapeutics has announced that its second-generation ARM-X anti-cancer vaccine, in combination with an anti-PD-1 immune-checkpoint inhibitor, has successfully inhibited the growth of pre-established ovarian cancer in animal models. The study demonstrated complete responses in nearly all treated animals, extending their survival beyond 80 days post-vaccination. This development highlights the versatility of Defence's ARM-X platform, which previously showed effectiveness against solid T-cell lymphoma, melanoma, and pancreatic cancer. The ARM-X vaccine requires lower antigen amounts, making it adaptable to patients' needs regardless of cancer type. The company is also testing ARM-X for colon cancer to set targets for upcoming Phase I-IIa trials.
Defence Therapeutics' Chief Scientific Officer, Dr. Moutih Rafei, discussed the company's Accum platform for cancer treatments on Money Talk Radio with Ellis Martin. The interview highlighted Defence's innovative approach in the field of immune-oncology, focusing on the enhancement of vaccine efficacy and drug delivery systems. The Accum platform aims to improve the targeting and effectiveness of cancer treatments, potentially transforming the landscape of oncology therapies. The discussion emphasized the platform's potential to make significant advances in cancer treatment.
Listeners can access the full interview on Money Talk Radio's website.
Defence Therapeutics (CSE: DTC) (OTCQB: DTCFF) is set to participate in the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting on June 11, 2024, in Toronto. This event is a key gathering for professionals involved in nuclear and molecular imaging. Defence will showcase AccuTRIC™, a novel Radio-Immuno-Conjugate developed with Orano Support SAS. AccuTRIC™ leverages Defence's AccuTOX® to enhance the treatment of hard-to-treat cancers. The technology aims to improve radiotherapy by using Auger electron emitter elements, which minimize damage to healthy tissues while maximizing therapeutic effects.
Defence Therapeutics announced the publication of a peer-reviewed study on AccuTOX, an anti-cancer molecule, in the Journal of Translational Medicine. The study details how AccuTOX synergizes with immune-checkpoint inhibitors to disrupt tumor growth. AccuTOX, derived from the Accum platform, shows enhanced killing potency, versatility, and ease of manufacturing. It induces immunogenic cell death and enhances cancer cell visibility to the immune system. The compound targets multiple cancer cell lines and has shown no apparent toxicity in animal models. Defence is initiating a Phase I trial and has submitted a CTA application to Health Canada.
Defence Therapeutics, a biopharmaceutical firm, announced the issuance and allowance of multiple patents across several Patent Families. The US Patent Office allowed application no. 18/169,440, enhancing the company's vaccine platform technology, Accum®, known for boosting antigen presentation. Recent pre-clinical studies using Defence's ARM-002™ vaccine showed significant antitumor responses, paving the way for Phase I trials.
Another patent in Australia for Defence's ADC platform was granted on February 1, 2024, further protecting Accum® and its variants, and adding to existing patents in the US, Japan, and Israel. Additionally, patents for Defence's vaccine platform technology were granted in Canada and Australia, with a Japanese patent expected soon. These patents cover methods and compositions for enhancing antigen immunogenicity.
CEO Mr. Plouffe highlighted the importance of these patents in Defence's mission to innovate and improve human health. The company is accelerating the examination of remaining applications via the Patent Prosecution Highway (PPH) program.
Defence Therapeutics Inc. announces successful completion of a pre-clinical vaccination trial using its ARM-002TM vaccine against pancreatic cancer, showing therapeutic effectiveness when combined with an immune-checkpoint inhibitor. Results reveal potent vaccine efficacy with tumor growth inhibition, positioning the company to target 'hard-to-treat' cancers like pancreatic cancer. The pancreatic cancer market is projected to exceed USD 36 billion by 2036.
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