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Defence Therapeu - DTCFF STOCK NEWS

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About Defence Therapeutics Inc. (DTCFF)

Defence Therapeutics Inc. is a publicly traded, clinical-stage biopharmaceutical company headquartered in Canada, specializing in engineering next-generation vaccines, antibody-drug conjugates (ADCs), and radiopharmaceutical products. At the heart of Defence’s innovation is its proprietary ACCUM® technology platform, a groundbreaking solution designed to optimize intracellular drug delivery by overcoming endosomal entrapment. This enhancement enables precise delivery of therapeutic agents directly to target cells, significantly increasing their efficacy and potency. Defence’s technology is particularly impactful in the fields of oncology and infectious diseases, addressing critical unmet medical needs.

Core Technology: The ACCUM® Platform

The ACCUM® technology is a versatile platform that enhances the delivery and efficacy of biologics, including ADCs, radiopharmaceuticals, vaccines, and protein therapeutics. By addressing the common challenge of endosomal entrapment, ACCUM® ensures that therapeutic agents reach their intended intracellular targets intact, thereby amplifying their therapeutic potential. This innovation is especially valuable in oncology, where precision delivery can improve treatment outcomes while minimizing side effects.

Key Applications and Innovations

  • Antibody-Drug Conjugates (ADCs): Defence’s ACCUM® technology enhances the potency of ADCs by ensuring efficient intracellular delivery of cytotoxic agents. This advancement has the potential to reduce dosing requirements and improve patient outcomes.
  • Radiopharmaceuticals: The company is developing novel radio-immuno-conjugates that leverage ACCUM® to deliver radioactive isotopes directly to cancer cells. This targeted approach minimizes damage to healthy tissues and enhances therapeutic efficacy.
  • Immune-Oncology Vaccines: Defence is pioneering vaccines that utilize ACCUM® to boost immunogenicity, making them more effective against cancers and infectious diseases.
  • GLP-1 Analog Development: Defence is exploring the use of ACCUM® to improve the stability and half-life of GLP-1 analogs, addressing challenges in the treatment of obesity and type 2 diabetes.

Business Model and Revenue Streams

Defence Therapeutics operates on a dual business model. It licenses its ACCUM® technology to pharmaceutical and biotech companies, generating immediate revenue while establishing its platform as an industry standard. Concurrently, the company invests in proprietary drug development programs, focusing on oncology and infectious diseases. This balanced approach ensures both near-term profitability and long-term growth.

Market Position and Competitive Landscape

Defence Therapeutics is strategically positioned in the rapidly growing biopharmaceutical and radiopharmaceutical markets. The global cancer immunotherapy market, for instance, is projected to grow significantly, driven by advancements in targeted therapies. Defence’s focus on enhancing the delivery and efficacy of biologics sets it apart from competitors, which include established pharmaceutical companies and emerging biotech firms. Its robust intellectual property portfolio, with patents in multiple jurisdictions, further strengthens its competitive edge.

Commitment to Innovation and Collaboration

Defence is actively involved in collaborative projects with leading research institutions and industry partners. Notable initiatives include its work with Canadian Nuclear Laboratories on radio-immuno-conjugates and its partnership with Orano Support SAS for advanced radiopharmaceutical development. These collaborations underscore Defence’s commitment to leveraging external expertise to accelerate innovation.

Conclusion

With its cutting-edge ACCUM® technology, diversified business model, and strategic focus on oncology and infectious diseases, Defence Therapeutics Inc. is at the forefront of biopharmaceutical innovation. Its dedication to addressing critical medical challenges and its robust intellectual property portfolio position the company as a key player in the global healthcare landscape.

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Defence Therapeutics Inc. announces the closing of the 2nd tranche of its non-brokered private placement, raising $600,000 for advancing preclinical and clinical programs.
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Defence Therapeutics Inc. receives US patent for its breakthrough AccuTOX technology, providing market exclusivity until 2042. The technology induces cancer cell death and shows promising results in pre-clinical studies, leading to FDA approval for Phase I clinical trials in melanoma patients.
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Defence Therapeutics Inc. announces a peer-reviewed study on its Accum®-E7 vaccine for cervical cancer treatment. The study, published in Cancer Science, highlights the vaccine's dual anti-cancer properties, prophylactic and therapeutic benefits, and safety profile. Defence also updates on a private placement offering.
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Defence Therapeutics Inc. announces the closing of the 1st tranche of its non-brokered private placement, raising $850,500.00. The Company intends to use the net proceeds to advance its preclinical and clinical programs, including the Phase I clinical trial of Defence's AccuTOX administered intratumorally in patients with stage IIIB to IV melanoma, and for general working capital. The Offering consists of units priced at $1.50 per Unit, each containing one common share and one common share purchase warrant. The Company paid a cash finder's fee of $68,040.00 and issued Finder's Warrants to a certain qualified arm's length finder. All securities issued in connection with the Offering are subject to a statutory hold period of four months plus a day from their date of issue in accordance with applicable securities legislation.
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Defence Therapeutics Inc. announces an amendment to its financing, conducting a non-brokered private placement of up to $2,250,000. The company will use the net proceeds to advance its preclinical and clinical programs, including the Phase I clinical trial of Defence's AccuTOX administered intratumorally in patients with stage IIIB to IV melanoma, and for general working capital.
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Defence Therapeutics Inc. announces a non-brokered private placement of up to $2,790,000 to advance its preclinical and clinical programs, including the Phase I clinical trial of Defence's AccuTOX®. The company's common shares have been upgraded to OTCQB, and are now trading under the symbol 'DTCFF'.
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Defence Therapeutics Inc. (DTC) successfully tested a new formulation of its ACCUM-002TM Dimer CDCA-SV40, known as AccuTOX®, for lung-established tumors. The drug demonstrated enhanced therapeutic properties and broader application in cancer therapeutics, with successful preclinical studies and FDA clearance to begin a Phase I trial in patients with melanoma. The global cancer therapeutics market size is expected to reach US$393.61 billion by 2032, presenting significant growth opportunities for the company.
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Defence Therapeutics Inc. (CSE: DTC) (OTC Pink: DTCFF) (FSE: DTC) has received clearance from the U.S. FDA for its Phase I clinical trial of ACCUM-002TM Dimer CDCA-SV40, also known as AccuTOX®, as an injectable anticancer molecule for the treatment of solid cancer tumors. This marks a significant milestone for Defence in the immune-oncology field, positioning AccuTOX® as the company's flagship asset in the anti-cancer therapeutics field. The approval reflects the company's commitment to addressing unmet clinical needs and becoming a global leader in innovative anti-cancer therapies.
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Defence Therapeutics Inc. (CSE: DTC) (OTC Pink: DTCFF) (FSE: DTC) is pleased to announce the successful submission of an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) for its ACCUM-002TM Dimer CDCA-SV40, AccuTOX®, an injectable anticancer molecule. The IND application includes preclinical animal testing data, pharmacology, pharmacokinetics, and toxicology studies, and details of drug substance and product manufacturing. The company aims to advance AccuTOX® into a Phase I clinical trial by Q1-Q2 2024. The primary objective of the upcoming trial is to identify the best therapeutic dosing range for co-administration with Opdulag®, a BMS product, in treating patients with solid tumors.
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Defence Therapeutics Inc., a Canadian biopharmaceutical company, has received a Notice of allowance for its Canadian patent application. The patent covers key vaccine platform technologies that enhance the immunogenicity of protein subunit vaccines, potentially improving their efficacy and lowering antigen dose required. The company already has a counterpart US patent. Defence intends to leverage these patents to secure broad patent protection in other markets and explore licensing and partnering opportunities. The global oncology market is predicted to be worth around $536.01 billion by 2029.
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FAQ

What is the current stock price of Defence Therapeu (DTCFF)?

The current stock price of Defence Therapeu (DTCFF) is $0.789 as of February 28, 2025.

What is the market cap of Defence Therapeu (DTCFF)?

The market cap of Defence Therapeu (DTCFF) is approximately 35.6M.

What is Defence Therapeutics’ core technology?

Defence Therapeutics’ core technology is the ACCUM® platform, which optimizes intracellular delivery of therapeutic agents by overcoming endosomal entrapment, enhancing their efficacy and potency.

What are the key applications of ACCUM® technology?

ACCUM® technology is applied in antibody-drug conjugates (ADCs), radiopharmaceuticals, immune-oncology vaccines, and GLP-1 analog development, primarily targeting oncology and infectious diseases.

How does Defence Therapeutics generate revenue?

Defence generates revenue through licensing its ACCUM® technology to pharmaceutical and biotech companies and by developing proprietary drug programs in oncology and infectious diseases.

What differentiates Defence Therapeutics from competitors?

Defence’s ACCUM® technology addresses endosomal entrapment, a major limitation in drug delivery, enabling more effective and precise therapies. Its robust patent portfolio further strengthens its competitive position.

What industries does Defence Therapeutics operate in?

Defence operates in the biopharmaceutical and radiopharmaceutical industries, focusing on oncology, immunotherapy, and infectious disease treatments.

What are the company’s key collaborations?

Defence collaborates with Canadian Nuclear Laboratories on radio-immuno-conjugates and Orano Support SAS for advanced radiopharmaceutical development, among other initiatives.

What is the significance of Defence’s intellectual property portfolio?

Defence’s patents, covering its ACCUM® technology and its applications, provide market exclusivity and validate the innovative nature of its solutions, supporting licensing and strategic partnerships.

What challenges does Defence Therapeutics address in oncology?

Defence addresses challenges like endosomal entrapment, inefficient drug delivery, and side effects by enhancing the precision and efficacy of cancer therapies.
Defence Therapeu

OTC:DTCFF

DTCFF Rankings

DTCFF Stock Data

35.59M
52.80M
3.8%
Biotechnology
Healthcare
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