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Centogene N.V. (symbol: CNTG) is a leading global company in the field of genetic diagnostic testing for rare hereditary diseases. With an expansive test portfolio covering over 2,800 genes, as well as biochemical and biomarker tests, the company offers unparalleled expertise in whole exome sequencing and whole genome sequencing. Centogene's mission is to provide data-driven, life-changing answers to patients, physicians, and pharmaceutical companies by diagnosing the root causes of symptoms early on.
Centogene leverages its unique CentoMD® mutation database, integrating genetic and clinical information to deliver the highest quality genetic testing and biomarker development. This extensive database allows the company to maintain the largest systematic documentation of genetic results worldwide.
Beyond individual diagnostic services, Centogene is a pivotal partner for pharmaceutical companies, offering essential services such as early patient recruitment, epidemiological insights, biomarker discovery, and patient monitoring. The company operates in two main segments: pharmaceutical and diagnostics, serving regions including Europe, the Middle East, North America, and Latin America.
Recent achievements include the launch of innovative genomic and multiomic products, a significant joint venture in Saudi Arabia, and expanded collaborations with long-standing and new pharma partners. Despite the challenges posed by current financial markets, Centogene remains committed to growth and profitability, exploring strategic alternatives to unlock value for its stakeholders.
With ISO, CAP, and CLIA certified multiomic reference laboratories in Germany, Centogene's research and development efforts have led to over 285 peer-reviewed publications. The company's pioneering work in rare and neurodegenerative diseases has fostered collaborations with over 50 pharmaceutical partners, accelerating drug discovery and development.
To discover more about Centogene's products, pipeline, and patient-driven purpose, visit their website and follow them on LinkedIn.
CENTOGENE has published data from its Rostock International Parkinson's Disease (ROPAD) Study in The Lancet Neurology, supporting the association of a RAB32 gene mutation with Parkinson's disease (PD). The study analyzed Whole Genome Sequencing data from 3,354 PD patients, revealing that nine patients (0.3% of the cohort) carried the RAB32 c.213C>G mutation. This prevalence is significantly higher than the 0.002% found in general population databases.
Key findings include:
- The mutation's causal role in Parkinson's disease is supported
- Age at onset did not differ between mutation-positives and negatives
- Gender proportions and certain clinical characteristics differed
- The RAB32 Ser71Arg-associated haplotype supports a single founder mutational event
CENTOGENE has launched a ROPAD Consortium to continue driving PD research and treatment through collaborative efforts, aiming to streamline access to critical data and improve the potential for advancing treatment options.
CENTOGENE N.V., a life science company specializing in rare and neurodegenerative diseases, has received a delisting notice from Nasdaq due to non-compliance with the minimum USD 15 million market value requirement for publicly held shares. Trading of CENTOGENE's common stock on Nasdaq will be suspended on August 8, 2024. The company expects to begin trading on the OTC Markets Group platform under the symbol 'CNTGF' on the same day.
CENTOGENE has also applied to trade on the OTCQX Market in the coming weeks. The company does not plan to request a review of Nasdaq's decision. Despite ongoing efforts to complete a sale transaction as part of its strategic alternatives review process, CENTOGENE was unable to meet the compliance deadline of August 26, 2024, set by the Nasdaq panel.
CENTOGENE N.V. (Nasdaq: CNTG) has published groundbreaking data from its Rostock International Parkinson's Disease (ROPAD) Study in the Brain journal. The study reveals that approximately 15% of Parkinson's disease (PD) cases are linked to genetic factors, with about 90% of these genetically confirmed patients having variants in the LRRK2 or GBA1 genes. This discovery highlights the importance of genetic testing in PD patient care and opens up possibilities for gene-targeted clinical trials.
The study, which involved over 12,500 patients from 16 countries, investigated variants in 50 genes associated with PD. The findings underscore the need to integrate genetic testing into routine care for PD patients, potentially enabling access to available treatments and accelerating the development of gene-specific therapies. CENTOGENE has also launched a ROPAD Consortium to further drive PD research and treatment through collaborative efforts.
Critical Path Institute (C-Path) and Centogene (Nasdaq: CNTG) have signed a Memorandum of Understanding (MOU) to collaborate on drug development for lysosomal diseases (LDs). The partnership aims to leverage genetic and real-world data (RWD) to overcome barriers in developing therapies for LDs, such as Niemann-Pick disease type C, Gaucher disease types 2 and 3, and mucopolysaccharidosis type II.
CENTOGENE, a leader in genomic and multiomic testing, will provide genetic testing services, sample analysis reporting, and access to its extensive Biodatabank. C-Path will use its collaborative work groups to create tools that help drug developers. The partnership is expected to advance the development of safe and effective therapies for LDs, enhancing the quality of life for affected patients.
CENTOGENE (Nasdaq: CNTG) announced the adoption of all resolutions at its 2024 Annual General Meeting. Shareholders approved an extension for drafting annual accounts and board reports for the 2023 financial year. Ernst & Young Accountants LLP was appointed as the external auditor for the 2024 financial year. Additionally, a revised compensation structure for the Supervisory Board was adopted. The Management Board's authority to issue shares, grant subscription rights, limit/exclude pre-emption rights, and acquire shares and depository receipts was also extended.
Centogene (NASDAQ: CNTG) reported a 2% increase in total revenues for FY2023, reaching €48.5 million. The Diagnostics segment saw an 8% revenue increase to €33.7 million, while Pharma segment revenues decreased by 8% to €14.8 million. The company's gross profit margin fell to 36%, and its net loss increased by 12.2% to €35.8 million.
Centogene secured approximately $20 million and strengthened its cash position through collaborations with Lifera. The company also expanded its Biodatabank and launched several new diagnostic tools. Guidance for FY2024 predicts revenue growth between 10-15%.
Despite delays in Pharma timelines, Centogene is optimistic about 2024, expecting steady growth in its Diagnostics business and a strong Pharma orderbook. Strategic alternatives are being explored to create long-term value.
Centogene (Nasdaq: CNTG) has secured approximately $20 million in funding through an expanded relationship with Lifera, a biopharma company owned by Saudi Arabia's Public Investment Fund (PIF). This includes a $15 million purchase of Centogene’s accounts receivables and additional investments in their joint venture. The financing bolsters Centogene’s liquidity, supporting operations and strategic initiatives, and aims to help the company achieve EBITDA breakeven by year-end. Adjustments to a previous $30 million convertible loan from Lifera include extending the loan to 24 months and partial conversion at $0.79.
CENTOGENE and Evotec announced the discovery of a promising new molecule with potential to treat type 2 and type 3 Gaucher disease. The discovery stems from their ongoing drug discovery partnership initiated in 2020, now extended for another year. Evotec has received an R&D license for continued development and has an exclusive option until March 31, 2025, to license CENTOGENE’s share of the IP. If exercised, CENTOGENE will receive an upfront fee, milestone payments, and royalties. Preclinical studies show the molecule has high brain penetration and metabolic stability, indicating significant progress towards a treatment for neuronopathic Gaucher disease.
CENTOGENE N.V. (Nasdaq: CNTG) announced significant growth in the CENTOGENE Biodatabank, with over 850,000 diverse patient insights for rare and neurodegenerative diseases. The data aids in precise diagnosis, new genetic variant identification, and drug development de-risking. With patients from 120+ countries, the biobank supports a vast diagnostic testing portfolio, 300 publications, and 48 pharma collaborations.
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