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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Bicycle Therapeutics (NASDAQ: BCYC) reported significant clinical progress in its oncology pipeline during Q1 2022, including promising interim data for the BT8009 Phase I clinical trial with a 50% overall response rate in patients with urothelial cancer. As of March 31, 2022, the company has $407.4 million in cash and equivalents, expected to fund operations through 2024. However, it reported a net loss of $27.6 million, or $(0.93) per share, compared to a loss of $16.2 million in Q1 2021.
Egle Therapeutics SAS has appointed Pierre Legault as Chairman and board member, effective March 2022. With over 35 years of experience in the biotech sector, his leadership is anticipated to enhance Egle's efforts in developing novel immunotherapies targeting regulatory T cells (Tregs) for oncology and autoimmune diseases. Mr. Legault's previous roles include Director at Syndax Pharmaceuticals and Chairman at Bicycle Therapeutics (BCYC), positioning him well to accelerate Egle's strategic initiatives.
Bicycle Therapeutics (NASDAQ: BCYC) announced interim Phase I results for BT8009, a second-generation BTC targeting Nectin-4, at the 2022 AACR Annual Meeting. The overall confirmed response rate was 50%, with one complete response among eight urothelial cancer patients at a 5.0mg/m² dosage. No dose-limiting toxicities were observed, and the tolerability profile remained favorable. Four of five responders are still on therapy after 24 weeks. The Phase I trial continues to explore additional dosing options. A conference call will provide further insights.
Bicycle Therapeutics (NASDAQ: BCYC) announced the presentation of interim Phase I results for BT8009, targeting Nectin-4, at the 2022 American Association for Cancer Research Annual Meeting. The oral presentation titled BT8009-100 Phase I/II Study will be on April 10, 2022, at 4:05 PM CT, presented by Meredith McKean from the Sarah Cannon Research Institute. Following the presentation, the company will hold a conference call on April 11, 2022, at 8:30 AM ET to discuss the findings.
Bicycle Therapeutics (NASDAQ: BCYC) announced updated preclinical results demonstrating the efficacy of its Bicycle® technology as a novel antiviral therapy against SARS-CoV-2. Presented at the 2022
Bicycle Therapeutics (NASDAQ: BCYC) will participate in a fireside chat at the 21st Annual Needham Virtual Healthcare Conference on April 13, 2022, at 8:45 a.m. ET. The event will be available via a live webcast on Bicycle's website, with an archived replay accessible for 90 days post-event. Bicycle Therapeutics specializes in pioneering therapeutics using its proprietary Bicycle technology, focusing on clinical-stage biopharmaceuticals that target underserved diseases. Current development includes BT5528, BT8009, BT7480, and BT1718 across various trials.
Bicycle Therapeutics (NASDAQ: BCYC) announced that interim Phase I results from the ongoing Phase I/II trial of BT8009, targeting Nectin-4, will be presented at the 2022 American Association for Cancer Research Annual Meeting in New Orleans from April 8-13. The company will discuss these results in a conference call on April 11, 2022, at 8:30 a.m. ET. Additionally, four abstracts are selected for presentation, including details on BT7480 and BCY6033, highlighting advancements in Bicycle's novel therapeutics.
Bicycle Therapeutics (NASDAQ: BCYC) will participate in a fireside chat at the Oppenheimer 32nd Annual Healthcare Conference on March 15, 2022, at 8:00 a.m. ET. The event will occur virtually, and interested parties can access a live webcast through the Investors and Media section of the company's website. An archived version of the chat will be available for 90 days following the event. Bicycle Therapeutics is focused on developing innovative therapeutics using its proprietary Bicycle technology, targeting diseases with limited treatment options.
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