Bicycle Therapeutics to Present at the 2023 AACR Annual Meeting

Rhea-AI Summary

Bicycle Therapeutics plc (NASDAQ: BCYC) has announced its participation in the 2023 American Association for Cancer Research (AACR) Annual Meeting, scheduled from April 14-19, 2023 in Orlando, FL. The company will present four posters highlighting its innovative bicyclic peptide technology aimed at enhancing cancer treatment.

The presentations include:

• NK-TICA™ Agonist - Modulation of natural killer cell immune response on April 17.
• In Vivo Models for NK-TICA™ - Evaluation of a novel immune cell agonist on April 17.
• BT7455 - Anti-tumor efficacy study on April 17.
• BT7480 - Phase 1/2 study on April 18.

Further details will be available post-presentation on bicycletherapeutics.com.

CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)-- Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle^®) technology, today announced that the company will present four poster presentations at the 2023 American Association for Cancer Research (AACR) Annual Meeting, taking place in Orlando, FL on April 14-19, 2023.

Poster Presentation Details:

Title: Modulation of natural killer cell immune response to tumor with novel synthetic tumor-immune cell agonist, NK-TICA^™
Session Title: Immunomodulatory Agents and Interventions 1
Date and Time: Monday, April 17, 2023 at 9:00 a.m. ET
Abstract Number: 1806
Speaker/Lead Author: Fay Dufort, Bicycle Therapeutics

Title: Development of in vivo models for evaluation of NK-TICA^™, novel Bicycle® tumor-targeted immune cell agonist^® designed to engage NK cells
Session Title: Immunomodulatory Agents and Interventions 1
Date and Time: Monday, April 17, 2023 at 9:00 a.m. ET
Abstract Number: 1826
Speaker/Lead Author: Lukas Stanczuk, Bicycle Therapeutics

Title: EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle^® tumor-targeted immune cell agonist^®
Session Title: Immunomodulatory Agents and Interventions 2
Date and Time: Monday, April 17, 2023 at 9:00 a.m. ET
Abstract Number: 1832
Speaker/Lead Author: Lia Luus, Bicycle Therapeutics

Title: Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with Nectin-4 associated advanced malignancies
Session Title: Phase I and First-in-Human Clinical Trials in Progress
Date and Time: Tuesday, April 18, 2023 at 1:30 p.m. ET
Abstract Number: CT253
Speaker/Lead Author: Thomas R. Jeffry Evans, MBBS: School of Cancer Sciences, University of Glasgow

The posters will be made available on the Publications section of bicycletherapeutics.com following the presentations.

About Bicycle Therapeutics

Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC™) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle TICA™ targeting Nectin-4 and agonizing CD137, in company-sponsored Phase I/II trials. In addition, BT1718, a BTC that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial sponsored by the Cancer Research UK Centre for Drug Development. Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA. For more information, visit bicycletherapeutics.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230414005025/en/

Investors:

David Borah, CFA

SVP, Capital Markets & Corporate Communications

david.borah@bicycletx.com

617-203-8300



Media:

Argot Partners

Sarah Sutton

bicycle@argotpartners.com

212-600-1902

Source: Bicycle Therapeutics plc

FAQ

What presentations will Bicycle Therapeutics showcase at the 2023 AACR Annual Meeting?

Bicycle Therapeutics will present four posters at the AACR Annual Meeting, covering topics such as NK-TICA™ agonist and BT7455 and BT7480 studies.

When is the AACR Annual Meeting taking place where Bicycle Therapeutics will present?

The AACR Annual Meeting will occur from April 14-19, 2023, in Orlando, FL.

What is the focus of the presentations by Bicycle Therapeutics at AACR?

The focus will be on innovative treatments involving their proprietary bicyclic peptide technology, specifically targeting immune responses in cancer.

What are the key dates for Bicycle Therapeutics' presentations at the AACR meeting?

Bicycle Therapeutics' presentations are scheduled for April 17 and April 18, 2023.

Where can I find the presentations made by Bicycle Therapeutics at AACR?

The presentations will be available on the Publications section of bicycletherapeutics.com following the event.