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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Nerviano Medical Sciences announced the appointment of Terrence West as New Business, Virtual CEO, tasked with enhancing the value of its oncology drug asset NMS-173. With over 25 years in biopharma and expertise in drug development, West aims to strategically position NMS-173, a dual IDH1/IDH2 inhibitor, against current cancer therapies. The drug shows promise in overcoming resistance mechanisms and has demonstrated significant anti-tumor activity. This leadership move reflects Nerviano's intent to strengthen its presence in the Boston biotech market.
Bicycle Therapeutics plc (NASDAQ: BCYC) will present results from its Phase I/II trial of BT8009 at the 2023 ASCO GU Cancers Symposium, taking place in San Francisco from February 16-18, 2023. The conference call, scheduled for February 14 at 8:00 a.m. ET, will feature Dr. Capucine Baldini and Dr. Daniel Petrylak discussing the data on BT8009, a BTC targeting Nectin-4. The poster presentation, under the title 'BT8009-100,' will occur on February 17. Bicycle Therapeutics specializes in innovative therapies, focusing on advanced malignancies.
Bicycle Therapeutics (NASDAQ:BCYC) announced the FDA's grant of Fast Track Designation for its BT8009 monotherapy targeting urothelial cancer. This designation aims to expedite the development of therapies addressing serious unmet medical needs. CEO Kevin Lee highlighted the importance of this FTD for aligning with the FDA to meet patient needs. Fast Track programs can benefit from more frequent FDA interactions and may qualify for Accelerated Approval and Priority Review if criteria are met, indicating progress in BT8009’s development.
Bicycle Therapeutics (NASDAQ: BCYC) announced the presentation of preclinical data for BT7480 and BT7455 at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) in Boston, from November 8-12, 2022. Five posters will be presented, highlighting innovative findings related to tumor-targeted immune cell agonists. Notable topics include the efficacy of Bicycle NK-TICA and the evaluation of humanized animal models. This event underscores Bicycle's commitment to advancing their proprietary bicyclic peptide technology in cancer therapy.
Bicycle Therapeutics (NASDAQ:BCYC) has announced updates from the ongoing Phase I/II trial of its therapy BT8009, targeting cancers expressing Nectin-4. The Phase I dose escalation is complete, establishing recommended doses of 5mg/m² and 7.5mg/m² for the Phase II expansion, where the first patient has already been dosed. Encouraging responses were observed in patients with non-small cell lung cancer and urothelial cancer, including confirmed responses consistent with earlier findings. Results will be shared at a conference in 2023.
Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology firm specializing in innovative therapeutics, has announced its participation in several upcoming investor conferences in November and December 2022. Notable events include the Cowen’s 6th Annual IO Next Summit on November 11 and the Jefferies London Healthcare Conference on November 17, among others. Live webcasts of the fireside chats will be available on the company’s website, with archived versions accessible for 90 days. Bicycle Therapeutics focuses on developing novel peptide-based medicines for underserved diseases.
Bicycle Therapeutics (NASDAQ: BCYC) reported third-quarter 2022 financial results, highlighting clinical progress across its pipeline. The company anticipates completing enrollment in the BT5528 initial dose expansion cohorts by Q4. A significant $10 million option fee from Genentech enhances their financial position, with cash and equivalents at $361.5 million, providing a runway into 2025. However, R&D expenses rose to $22.8 million, impacting net loss, which widened to $28.3 million or $(0.96) per share compared to $(0.59) in Q3 2021.
Ambi Robotics has secured $32 million in funding, aiming to enhance its AI-powered parcel sorting systems due to rising demand, especially during the holiday season. Existing investors, including Tiger Global and Bow Capital, are joined by Ahren and strategic partner Pitney Bowes (NYSE:PBI). This funding follows a previous $23 million deployment expansion with Pitney Bowes, facilitating more than 80 installations of AmbiSort A-Series systems. The technology promises to boost warehouse efficiency, with each system increasing throughput to over 1,200 items per hour.
Bicycle Therapeutics plc (NASDAQ: BCYC) has announced the publication of preclinical data for BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, in the Journal of Medicinal Chemistry. This study, alongside previous research, supports BT8009's development for treating Nectin-4 expressing tumors, which are prevalent in various solid cancers. The company is currently evaluating BT8009 in a Phase I/II clinical trial. Bicycle's innovative Bicycle technology aims to create effective therapies for underserved cancer indications.
Bicycle Therapeutics plc (NASDAQ: BCYC) announced the publication of preclinical data for BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, in Molecular Cancer Therapeutics. The article details its efficacy in killing solid tumor cells, with significant tumor regression observed in various models. The results follow positive interim findings from its Phase I trial, which suggest BT8009's potential for treating solid tumors effectively. Additional clinical data is expected later this year, underscoring the drug’s promising development trajectory.
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