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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Bicycle Therapeutics (NASDAQ: BCYC) has appointed Santiago Arroyo, M.D., Ph.D., as Chief Development Officer effective March 31. Dr. Arroyo brings over 20 years of experience, having previously served as Chief Medical Officer at Momenta Pharmaceuticals. He will oversee the clinical development of Bicycle’s expanding pipeline, including programs in oncology. Jennifer Perry, Pharm.D., has been promoted to Senior Vice President, Commercial, with over 15 years of experience in oncology. The transition includes the departure of Chief Medical Officer Dr. Dominic Smethurst. These leadership changes aim to position Bicycle for continued growth and success in late-stage development.
Bicycle Therapeutics has announced a strategic collaboration with Novartis to develop targeted radioligand therapies for oncology. Under this agreement, Bicycle will receive a
Bicycle Therapeutics (NASDAQ: BCYC) announced participation in two investor conferences in March 2023. The company will host a fireside chat at Cowen's 43rd Annual Health Care Conference on March 7 at 9:50 a.m. ET, and at the Barclays Global Healthcare Conference on March 16 at 9:00 a.m. ET. Live webcasts of these discussions will be available on the company's website, with archived replays accessible for 90 days post-event. Bicycle Therapeutics specializes in developing a new class of therapeutics using its proprietary Bicycle technology, targeting underserved diseases with high-affinity and selectivity.
Bicycle Therapeutics (NASDAQ: BCYC) reported fourth-quarter and full-year 2022 results, highlighting significant progress with advanced clinical trials for BT8009, BT5528, and BT7480. BT8009 received Fast Track Designation from the FDA, and Phase I results showed anti-tumor activity in treated patients. The company has a cash position of $339.2 million, expected to support operations into 2025. R&D expenses rose to $81.6 million in 2022, leading to a net loss of $112.7 million, or $(3.80) per share. Further updates on trials are anticipated by the end of 2023, positioning the company for future milestones.
Bicycle Therapeutics (NASDAQ: BCYC) announced promising results from the Phase I trial of BT8009, a novel BTC targeting Nectin-4, showing a 50% overall response rate and a 75% clinical benefit rate in urothelial cancer. A complete response was recorded at the 5 mg/m² dose. As of
Bicycle Therapeutics plc (NASDAQ:BCYC), a pioneering biotechnology firm, will participate in a fireside chat at the SVB Securities Global Biopharma Conference on February 15, 2023, at 9:20 a.m. ET. This event will be held virtually, and a live webcast will be accessible on their website, www.bicycletherapeutics.com. The archived version of the chat will be available for 90 days. Bicycle Therapeutics specializes in developing novel therapeutics, called Bicycles, which are designed for diseases lacking effective treatments. Their ongoing clinical trials include BT5528, BT8009, BT7480, and BT1718, targeting various significant tumor antigens.
The report titled "Non-Viral / Intracellular Drug Delivery Systems Market" by ResearchAndMarkets.com highlights the rising demand for efficient drug delivery systems in the biopharmaceutical industry. It notes that over 20% of the proteome resides within cell membranes, necessitating innovative delivery methods for therapeutic intervention. Key advancements include non-viral systems such as exosome-based techniques and cell-penetrating peptides. The report reveals that around 1,300 patents have been filed, indicating substantial innovation, with over 20,000 studies on oligonucleotide-based therapeutics underway. The market is expected to grow significantly in the near term.
Nerviano Medical Sciences announced the appointment of Terrence West as New Business, Virtual CEO, tasked with enhancing the value of its oncology drug asset NMS-173. With over 25 years in biopharma and expertise in drug development, West aims to strategically position NMS-173, a dual IDH1/IDH2 inhibitor, against current cancer therapies. The drug shows promise in overcoming resistance mechanisms and has demonstrated significant anti-tumor activity. This leadership move reflects Nerviano's intent to strengthen its presence in the Boston biotech market.
Bicycle Therapeutics plc (NASDAQ: BCYC) will present results from its Phase I/II trial of BT8009 at the 2023 ASCO GU Cancers Symposium, taking place in San Francisco from February 16-18, 2023. The conference call, scheduled for February 14 at 8:00 a.m. ET, will feature Dr. Capucine Baldini and Dr. Daniel Petrylak discussing the data on BT8009, a BTC targeting Nectin-4. The poster presentation, under the title 'BT8009-100,' will occur on February 17. Bicycle Therapeutics specializes in innovative therapies, focusing on advanced malignancies.
Bicycle Therapeutics (NASDAQ:BCYC) announced the FDA's grant of Fast Track Designation for its BT8009 monotherapy targeting urothelial cancer. This designation aims to expedite the development of therapies addressing serious unmet medical needs. CEO Kevin Lee highlighted the importance of this FTD for aligning with the FDA to meet patient needs. Fast Track programs can benefit from more frequent FDA interactions and may qualify for Accelerated Approval and Priority Review if criteria are met, indicating progress in BT8009’s development.
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