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Bicycle Therapeutics plc (symbol: BCYC) is a pioneering clinical-stage biotechnology company with a mission to transform the pharmaceutical industry through its innovative Bicycle® product platform. This revolutionary platform focuses on developing a new class of medicines known as Bicycles, which are synthetic short peptides constrained to form two loops. These loops stabilize their structural geometry, granting them superior targeting abilities and efficiency compared to existing drug conjugate modalities.
The core business of Bicycle Therapeutics centers around creating transformational new therapies to enhance treatment options in oncology and other serious diseases. The company’s leading product candidate, BT1718, is a Bicycle Toxin Conjugate (BTC) designed to maximize tumor penetration while minimizing adverse effects on healthy tissues. Bicycles combine the beneficial properties of multiple therapeutic entities in a single modality – showcasing the affinity and selective pharmacology typical of antibodies, the rapid distribution kinetics of small molecules, and the adjustable pharmacokinetic half-life of peptides.
Bicycle Therapeutics is committed to addressing high unmet medical needs, particularly in oncology. Their proprietary IP is grounded in the groundbreaking work of scientific founders, and the company has made significant strides with their unique approach. Recent achievements include successful clinical trials and strategic partnerships aimed at advancing their robust pipeline of product candidates.
This innovative approach ensures that Bicycles exhibit a favorable safety profile and improved tolerability, making them a promising alternative to traditional therapies. As the company continues to evolve, it remains dedicated to enhancing patient outcomes and pioneering new treatment paradigms in the biotech space.
Bicycle Therapeutics plc (NASDAQ: BCYC) has announced its participation in the 2023 American Association for Cancer Research (AACR) Annual Meeting, scheduled from April 14-19, 2023 in Orlando, FL. The company will present four posters highlighting its innovative bicyclic peptide technology aimed at enhancing cancer treatment.
The presentations include:
- NK-TICA™ Agonist - Modulation of natural killer cell immune response on April 17.
- In Vivo Models for NK-TICA™ - Evaluation of a novel immune cell agonist on April 17.
- BT7455 - Anti-tumor efficacy study on April 17.
- BT7480 - Phase 1/2 study on April 18.
Further details will be available post-presentation on bicycletherapeutics.com.
ResearchAndMarkets.com has released the report "Global Genetic Disorders Partnering 2016-2023," providing a comprehensive overview of genetic disorder deals signed worldwide since 2016. The report captures key aspects including deal trends, financial terms, and the most active dealmakers in the biopharma industry. It includes detailed analyses of deal structures, contract documents, and financial metrics, such as headline values, upfront payments, and royalty rates. Covering multiple genetic disorders like Cystic Fibrosis and Huntington's Disease, this report aims to be an essential resource for stakeholders in genetic disorder collaborations.
The report titled Global Cardiovascular Partnering 2016-2023, released by ResearchAndMarkets.com, analyzes cardiovascular disease deals from major pharmaceutical and biotechnology firms worldwide since 2016. Key insights include trends in cardiovascular partnering, financial deal terms, and structures.
It evaluates over 850 cardiovascular deals, detailing upfront payments, milestone payments, and royalties. The report is segmented to provide valuable benchmarking and analysis, including an overview of leading dealmakers and the financial metrics of significant agreements. This resource aims to inform prospective dealmakers in cardiovascular technology and product commercialization.
Bicycle Therapeutics (NASDAQ: BCYC) has appointed Santiago Arroyo, M.D., Ph.D., as Chief Development Officer effective March 31. Dr. Arroyo brings over 20 years of experience, having previously served as Chief Medical Officer at Momenta Pharmaceuticals. He will oversee the clinical development of Bicycle’s expanding pipeline, including programs in oncology. Jennifer Perry, Pharm.D., has been promoted to Senior Vice President, Commercial, with over 15 years of experience in oncology. The transition includes the departure of Chief Medical Officer Dr. Dominic Smethurst. These leadership changes aim to position Bicycle for continued growth and success in late-stage development.
Bicycle Therapeutics has announced a strategic collaboration with Novartis to develop targeted radioligand therapies for oncology. Under this agreement, Bicycle will receive a
Bicycle Therapeutics (NASDAQ: BCYC) announced participation in two investor conferences in March 2023. The company will host a fireside chat at Cowen's 43rd Annual Health Care Conference on March 7 at 9:50 a.m. ET, and at the Barclays Global Healthcare Conference on March 16 at 9:00 a.m. ET. Live webcasts of these discussions will be available on the company's website, with archived replays accessible for 90 days post-event. Bicycle Therapeutics specializes in developing a new class of therapeutics using its proprietary Bicycle technology, targeting underserved diseases with high-affinity and selectivity.
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