BrainTransporter™ dramatically improves antibody delivery to the brain
BioArctic AB has unveiled its proprietary BrainTransporter (BT) platform at the PEGS conference in Barcelona. The technology demonstrates up to 70-fold higher penetration of antibodies across the blood-brain barrier using Transferrin Receptor-mediated transport, without negative effects on hematological safety. The platform shows rapid, broad, and deep distribution of amyloid-beta antibodies across the brain in preclinical models. In April 2024, BioArctic and Eisai entered a research evaluation agreement for BAN2802, combining BT technology with an Alzheimer drug candidate.
BioArctic AB ha presentato la sua piattaforma proprietaria BrainTransporter (BT) alla conferenza PEGS di Barcellona. La tecnologia dimostra una penetrazione fino a 70 volte superiore degli anticorpi attraverso la barriera emato-encefalica, utilizzando il trasporto mediato dal recettore della transferrina, senza effetti negativi sulla sicurezza ematologica. La piattaforma mostra una distribuzione rapida, ampia e profonda degli anticorpi contro l'amiloide-beta nel cervello in modelli preclinici. Nel mese di aprile 2024, BioArctic ed Eisai hanno firmato un accordo di valutazione della ricerca per BAN2802, combinando la tecnologia BT con un candidato farmaco per l'Alzheimer.
BioArctic AB ha presentado su plataforma propietaria BrainTransporter (BT) en la conferencia PEGS en Barcelona. La tecnología demuestra una penetración hasta 70 veces mayor de anticuerpos a través de la barrera hematoencefálica mediante el transporte mediado por el receptor de transferrina, sin efectos negativos sobre la seguridad hematológica. La plataforma muestra una distribución rápida, amplia y profunda de anticuerpos contra el amiloide-beta en el cerebro en modelos preclínicos. En abril de 2024, BioArctic y Eisai firmaron un acuerdo de evaluación de investigación para BAN2802, combinando la tecnología BT con un candidato de fármaco para el Alzheimer.
BioArctic AB가 바르셀로나에서 열린 PEGS 컨퍼런스에서 자체 플랫폼인 BrainTransporter (BT)를 공개했습니다. 이 기술은 트랜스페린 수용체 매개 수송을 사용하여 혈액-뇌 장벽을 통해 70배 더 높은 침투율을 보여주며, 혈액학적 안전성에 부정적인 영향을 미치지 않습니다. 이 플랫폼은 전임상 모델에서 뇌 내 아밀로이드-beta 항체의 빠르고 넓은 분포를 나타냅니다. 2024년 4월, BioArctic와 Eisai는 BT 기술과 알츠하이머 약물 후보를 결합한 BAN2802에 대한 연구 평가 계약을 체결했습니다.
BioArctic AB a dévoilé sa plateforme propriétaire BrainTransporter (BT) lors de la conférence PEGS à Barcelone. La technologie démontre une pénétration jusqu'à 70 fois plus élevée des anticorps à travers la barrière hémato-encéphalique en utilisant le transport médié par le récepteur de transferrine, sans effets négatifs sur la sécurité hématologique. La plateforme montre une distribution rapide, large et profonde des anticorps anti-amyloïde-bêta dans le cerveau dans des modèles précliniques. En avril 2024, BioArctic et Eisai ont signé un accord d'évaluation de recherche pour BAN2802, combinant la technologie BT avec un candidat médicament pour la maladie d'Alzheimer.
BioArctic AB hat seine proprietäre Plattform BrainTransporter (BT) auf der PEGS-Konferenz in Barcelona vorgestellt. Die Technologie zeigt eine bis zu 70-fach höhere Penetration von Antikörpern über die Blut-Hirn-Schranke unter Verwendung eines transferrin-rezeptorvermittelten Transports, ohne negative Auswirkungen auf die hämatologische Sicherheit. Die Plattform zeigt eine schnelle, breite und tiefe Verteilung von Amyloid-Beta-Antikörpern im Gehirn in präklinischen Modellen. Im April 2024 schlossen BioArctic und Eisai eine Forschungsbewertungsvereinbarung für BAN2802 ab, die die BT-Technologie mit einem Alzheimer-Arzneimittelkandidaten kombiniert.
- Technology achieves 70-fold increase in brain antibody delivery
- No negative effects on hematological safety parameters observed
- Existing partnership agreement with Eisai for BAN2802
- Multiple potential partnering opportunities across different therapy areas
- Technology still in preclinical stage
- No guaranteed success in clinical development or regulatory approval
Insights
The BrainTransporter platform represents a significant breakthrough in CNS drug delivery technology. The 70-fold increase in brain penetration for antibodies is unprecedented in the field and could revolutionize treatment approaches for neurological disorders. The technology's ability to leverage the natural TfR pathway while maintaining safety is particularly noteworthy.
The platform's versatility and demonstrated safety profile make it highly valuable for potential partnerships across multiple therapeutic areas. The existing agreement with Eisai, a major player in Alzheimer's treatment, validates the technology's commercial potential. This could lead to improved efficacy of existing CNS drugs and enable development of new therapeutics previously by poor brain penetration.
This technology positions BioArctic advantageously in the lucrative CNS therapeutics market. The partnership with Eisai demonstrates early commercial validation and the platform's broad applicability opens multiple revenue streams through potential licensing deals. The ability to improve existing drugs' efficacy while potentially reducing dosing requirements presents a compelling value proposition for both pharmaceutical partners and healthcare systems.
The market impact extends beyond Alzheimer's disease to other CNS disorders, representing a significant expansion of BioArctic's addressable market. The technology could become an essential platform for developing next-generation CNS therapeutics, potentially generating substantial licensing revenues.
During the 16th annual Protein & Antibody Engineering Summit (PEGS)
Brain uptake of biotherapeutics such as antibodies and enzymes is severely limited by the blood brain barrier (BBB) primarily due to their size. Active transport across the BBB, using one of the body's own delivery mechanisms, aims to enable better drug uptake into the brain. The BT technology utilizes the Transferrin Receptor (TfR), a protein facilitating transport across the BBB, to optimize brain delivery.
The PEGS summit presentation included results in preclinical models demonstrating up to 70-fold increase of amyloid-beta antibody brain exposure using the BT technology, with a rapid, broad and deep distribution of amyloid-beta antibodies across the brain. The results provide preclinical validation of a BT-linked amyloid-beta monoclonal antibody, without negative effects on hematological parameters including reticulocytes.
"I am excited that we now can present our excellent preclinical data with the BrainTransporter technology. This technology has huge potential to improve many therapies by helping more drug reach its target in the brain, and could thereby in the future offer patients with different brain disorders new treatment opportunities," said Gunilla Osswald, CEO at BioArctic. "The technology has the potential to create faster and improved efficacy of treatments targeted to the brain with less side effects and lower doses for the benefit of both patients and society."
The BT technology could be used in a number of different therapy areas, giving BioArctic many potential future partnering opportunities. A first agreement with the BT-technology was signed in April 2024, when BioArctic AB and Eisai Co., Ltd., entered into a research evaluation agreement regarding BAN2802, a potential new treatment combining BioArctic's proprietary BrainTransporter technology with an undisclosed Alzheimer drug candidate.
This release discusses investigational uses of an agent in development and is not intended to convey conclusions about efficacy or safety. There is no guarantee that such investigational agents will successfully complete clinical development or gain health authority approval.
The information was released for public disclosure, through the agency of the contact person above, at 3.00 p.m. CET on November 6, 2024.
For more information, please contact:
Oskar Bosson, Vice President Communications and Investor Relations
Telephone: + 46 70 410 71 80
E-mail: oskar.bosson@bioarctic.com
About the BrainTransporter technology
BioArctic's BrainTransporter technology is a technology for facilitating the passage of biological drugs as for example antibodies into the brain using the transferrin receptor (TfR). Active transport of biotherapeutics across the blood brain barrier can result in broader brain distribution enabling better efficacy, improved safety profile and dosing convenience. The technology is being applied to several in-house drug projects and could become part of future collaborations with other pharma companies.
About BioArctic
BioArctic AB (publ) is a Swedish research-based biopharma company focusing on treatments that can delay or stop the progression of neurodegenerative diseases. The company invented Leqembi® (lecanemab) - the world's first drug proven to slow the progression of the disease and reduce cognitive impairment in early Alzheimer's disease. Leqembi has been developed together with BioArctic's partner Eisai, who are responsible for regulatory interactions and commercialization globally. In addition to Leqembi, BioArctic has a broad research portfolio with antibodies against Parkinson's disease and ALS as well as additional projects against Alzheimer's disease. Several of the projects utilize the company's proprietary BrainTransporter™ technology, which has the potential to actively transport antibodies across the blood-brain barrier to enhance the efficacy of the treatment. BioArctic's B share (BIOA B) is listed on Nasdaq Stockholm Large Cap. For further information, please visit www.bioarctic.com.
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SOURCE BioArctic
FAQ
What is the brain penetration improvement achieved by BioArctic's BrainTransporter platform?
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How does BioArctic's BrainTransporter technology work?
