ANGLE PLC S/ADR - ANPCY STOCK NEWS

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) has announced the issuance of 56,666 new ordinary shares due to the exercise of employee options. This will bring the total number of ordinary shares to 260,580,547, effective from December 7, 2022. The new shares rank equally with existing shares and have been submitted for trading on AIM. This issuance is part of the company's ongoing strategy to incentivize employees. The announcement also emphasizes the company's advancements in liquid biopsy technology, specifically through its FDA-cleared Parsortix system for capturing circulating tumor cells.

ANGLE plc has announced successful results from a multi-centre clinical study utilizing its Parsortix system to enrich circulating tumor cells (CTCs) from 207 metastatic breast cancer patients. The study demonstrated that CTCs could be analyzed using various downstream techniques, providing data for the successful De Novo FDA clearance of the Parsortix system on May 24, 2022. Notably, CTCs were detected in 48.5% of samples, highlighting the system's clinical utility for treatment monitoring and selection.

ANGLE plc presented its study at the International Society of Liquid Biopsy meeting, demonstrating the simultaneous analysis of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) from a single blood sample. The proof of concept study confirmed that isolating CTCs does not compromise ctDNA quality, adding significant value for cancer characterization and patient monitoring. This multimodal approach enhances precision medicine by allowing genetic, transcriptional, and protein-level insights, positioning ANGLE competitively in an expanding liquid biopsy market.

ANGLE plc, a leading liquid biopsy company, has announced the issuance of 25,000 new ordinary shares following the exercise of employee options. The new shares will rank equally with existing shares, raising the total number of ordinary shares to 260,523,881. The shares are expected to be admitted for trading on AIM on October 27, 2022. This move aims to enhance liquidity and shareholder participation while aligning employee interests with company performance.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) has announced the closure of its Toronto operations to streamline costs, saving approximately £2.6 million in 2023 and £4.0 million annually thereafter. The decision follows increasing operational costs in Canada due to currency fluctuations and changes in UK R&D tax credit rules, making UK-based operations more cost-effective. ANGLE plans to centralize R&D in Guildford, UK, without significant impact on ongoing operations. A one-off closure cost of £0.5 million is expected, but the move extends the company's cash runway into H2 2024.

On October 14, 2022, ANGLE plc announced a TR-1 notification revealing a change in voting rights as Aegon NV crossed a key threshold. As of October 12, Aegon holds 3.77% of voting rights attached to shares and 0.22% through financial instruments, totaling 3.99%. This marks a slight decrease from the previous position of 4.02%. The information indicates increased scrutiny of significant shareholders and their influence on company governance.

ANGLE plc (OTCQX:ANPCY) has entered a distribution agreement with Promedeus to roll out the Parsortix system in the Czech Republic, targeting metastatic breast cancer. This partnership capitalizes on Promedeus's experience in advanced medical equipment distribution and oncology sector knowledge. The Parsortix system, which is FDA cleared and CE marked, enables non-invasive harvesting of circulating tumor cells from blood. ANGLE anticipates similar deals in other territories as it expands its market presence.

ANGLE plc announced a significant change in its share ownership as a major stakeholder, Aegon NV, crossed the voting rights threshold of 3.80% on September 28, 2022. This acquisition increases Aegon's holdings to a total of 10,467,539 voting rights, reflecting 4.02% when considering voting rights from financial instruments. The notification was filed with the relevant authorities on September 29, 2022.

ANGLE plc has announced the issuance of 8,333 new ordinary shares following the exercise of employee options. This occurs in the context of their ongoing operations as a leader in liquid biopsy technology. The new shares will rank equally with existing shares, increasing the total number of ordinary shares to 260,498,881. The London Stock Exchange is set to admit these shares for trading starting October 5, 2022. This increase does not signify a direct financial challenge; however, it may indicate dilution for existing shareholders.