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Altimmune - ALT STOCK NEWS

Welcome to our dedicated page for Altimmune news (Ticker: ALT), a resource for investors and traders seeking the latest updates and insights on Altimmune stock.

Overview of Altimmune Inc

Altimmune Inc is a clinical-stage biopharmaceutical company that advances peptide-based therapeutics through innovative research and development. The company is focused on addressing major public health challenges by developing novel treatments for obesity, metabolic diseases, and liver conditions such as metabolic-associated steatohepatitis (MASH). Its product candidate, pemvidutide, harnesses the mechanism of a GLP-1/glucagon dual receptor agonist to mimic complementary physiological effects similar to diet and exercise. This approach aims to modulate appetite, increase energy expenditure, and affect lipid metabolism, which collectively contribute to substantial weight loss and improved metabolic profiles.

Innovative Therapeutic Approach

At the heart of Altimmune's strategy is the development of next-generation peptide-based therapeutics. The company’s investigational product, pemvidutide, leverages a dual agonist mechanism to bind and activate both the GLP-1 and glucagon receptors. This unique mechanism is designed to produce a synergistic effect, where the activation of GLP-1 suppresses appetite while glucagon stimulates energy expenditure and promotes favorable lipid metabolism. This dual receptor engagement differentiates Altimmune’s approach from traditional single-target treatments and positions the company as a contender in the evolving landscape of metabolic disease therapies.

Clinical Development and Research Focus

Altimmune stands out as an expert in the clinical-stage development of biotherapeutics. The company is currently engaged in intensive clinical research evaluating the safety, tolerability, and efficacy of pemvidutide in patients dealing with obesity and MASH. By conducting robust clinical trials that measure key health indicators such as weight loss, liver fat reduction, and improvements in serum lipid profiles, Altimmune is committed to establishing a comprehensive understanding of its product's benefits. This rigorous clinical approach helps to solidify the company’s reputation for precision and reliability within the biopharmaceutical research community.

Market Position and Competitive Landscape

Operating within an industry defined by rapid advancements in biotechnology and therapeutic innovation, Altimmune Inc has carved a niche by targeting complex metabolic conditions that are traditionally difficult to treat. Its emphasis on peptide therapeutics places it in direct competition with other clinical-stage companies pursuing similar targets in obesity and liver diseases. However, the strategic design of a dual receptor agonist not only distinguishes its product profile but also showcases the company’s deep technical expertise and understanding of disease pathways. This innovation is critical for positioning Altimmune as a significant contributor to next-generation treatment solutions in a competitive market landscape.

Scientific Rationale and Developmental Insights

The scientific premise behind Altimmune's research is rooted in the idea that the coordinated activation of multiple hormonal pathways can more effectively counteract complex metabolic disorders. By fostering a better balance between appetite suppression and energy metabolism, pemvidutide is engineered to ensure effective weight loss while preserving lean muscle mass, a critical factor when addressing obesity. These innovative insights into the interplay of metabolic processes underscore the company’s commitment to designing therapies that are both safe and effective.

Operational Strategy and Future Research Directions

While Altimmune Inc is primarily a research-driven entity without established revenue streams from commercial products, its ongoing clinical trials and technology platform underscore its commitment to transforming the treatment landscape in metabolic health. The company continues to build its clinical portfolio by exploring additional therapeutic indications that leverage the unique properties of its peptide-based platform technology. Its operational focus includes establishing partnerships, advancing clinical trials efficiently, and ensuring that manufacturing processes for its candidates meet rigorous quality standards.

Conclusion

Altimmune Inc exemplifies a forward-thinking, research-oriented approach in the realm of clinical-stage biopharmaceutical development. Through its innovative dual receptor agonist technology and deep understanding of metabolic biology, the company aims to deliver transformative therapies for obesity, metabolic diseases, and MASH. The detailed clinical research and robust development pipeline not only underscore its scientific acumen but also provide valuable insights for investors and stakeholders seeking to understand the critical dynamics of next-generation therapeutic solutions.

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AVG Group Sarl has made a strategic investment of approximately NOK 80,000,000 in Alternus Energy Group PLC, bolstering its position in the Nordic renewable energy sector. Alternus aims to become one of the largest pan-European solar operators by the end of the decade. This partnership will enable AVG to provide further financing and expertise in solar technology, enhancing Alternus's operations in Norway. Currently, Alternus has a portfolio of 39 solar parks with over 140 MWp capacity and plans to acquire an additional 1.2 GW of projects by 2023, aiming for over 2 GW by 2025.

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Altimmune, Inc. (Nasdaq: ALT) announced results from its Phase 1b trial evaluating the safety and immunogenicity of its intranasal anthrax vaccine candidate, NasoShield. The trial, supported by BARDA, involved 42 healthy volunteers. Key findings indicated significant serum binding antibody responses to the protective antigen compared to placebo. However, responses blocking anthrax toxin were lower than in previous studies with BioThrax. Importantly, 80% of subjects exhibited mucosal IgA responses. The vaccine was well-tolerated. Next steps will involve discussions with BARDA regarding further development funding.

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Altimmune, Inc. (Nasdaq: ALT) announced a collaboration with Summit Biosciences to manufacture a metered multidose nasal spray for its COVID-19 vaccine candidate, AdCOVID. This innovation aims to provide an easy vaccination method, especially in high-demand areas, benefiting from room temperature stability. Currently in a Phase 1 trial, AdCOVID is designed to generate systemic and mucosal immunity against SARS-CoV-2. Positive results from preclinical studies show strong immune responses and high protection rates.

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Altimmune, Inc. (Nasdaq: ALT) announced promising preclinical results for its intranasal COVID-19 vaccine candidate, AdCOVID. Conducted in collaboration with the University of Alabama at Birmingham and Saint Louis University, the studies demonstrated 100% protection against lethal SARS-CoV-2 challenges in mice and over a 1000-fold reduction in viral replication post-infection. Antibody responses were durable for at least six months. The Phase 1 clinical trial has begun with data expected in Q2 2021, highlighting AdCOVID’s potential as a leading vaccine candidate.

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Altimmune, Inc. expands its collaboration with Lonza to establish a dedicated suite for the production of its AdCOVID vaccine candidate at Lonza's Houston facility. This agreement aims to enhance manufacturing capacity for the intranasal COVID-19 vaccine, addressing current supply challenges. Altimmune is in Phase 1 trials of AdCOVID, with data expected in Q2 2021. The vaccine promises easy storage and a potential one-year immunity after a single dose. Preclinical studies suggest significant immune response activation, positioning AdCOVID as a potential leader in COVID-19 vaccination strategies.

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Altimmune announced management presentations at two upcoming conferences. A fireside chat at the H.C. Wainwright Global Life Sciences Conference will take place on March 9, 2021, featuring CEO Vipin Garg and other executives. Additionally, Chief Medical Officer Dr. Scott Harris will present at the NASH-TAG Conference on March 13, 2021, discussing dual GLP-1 agonists for treating liver dysfunction in NASH. Webcast links for both events are available on Altimmune's website, providing further insights into their innovative pipeline.

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Altimmune, Inc. (Nasdaq: ALT) has initiated enrollment in a Phase 1 clinical trial for AdCOVID, a single-dose intranasal COVID-19 vaccine aimed at generating both systemic and local immunity. The trial targets up to 180 healthy adults aged 18-55 to assess safety and immunogenicity. Results from preclinical studies show promising mucosal immunity responses, crucial for virus transmission prevention. The trial's full data readout is expected by Q2 2021, with the potential for room temperature stability enhancing distribution efficiency.

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Altimmune announced the commencement of enrollment in its Phase 1 clinical trial for AdCOVID, a novel intranasal COVID-19 vaccine. The company reported a significant increase in cash reserves to $216 million, up from $37 million year-over-year. Revenue rose to $8.2 million, driven by U.S. government contracts. However, net loss attributed to common stockholders increased to $49 million, reflecting higher R&D and administrative expenses. The company is advancing multiple clinical trials, including ALT-801 and T-COVID, with data readouts expected in 2021.

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Altimmune plans to report its full year 2020 financial results on February 25, 2021. The company will hold a conference call at 8:30 AM ET to discuss these results and provide a business update. Altimmune focuses on developing intranasal vaccines and immune modulating therapies, with a diverse pipeline including products for COVID-19, anthrax, influenza, and liver disease. The company's offerings include AdCOVID™, NasoShield™, NasoVAX™, T-COVID™, ALT-801, and HepTcell™.

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Altimmune, Inc. (Nasdaq: ALT) has received FDA clearance for its Phase 1 clinical trial of AdCOVID, a single-dose, intranasal COVID-19 vaccine, with patient enrollment set to begin next week. The trial aims to evaluate the safety and immunogenicity of AdCOVID in 180 healthy adults aged 18 to 55. Preclinical studies have shown promising immune responses, and AdCOVID is designed to stimulate both systemic and mucosal immunity. The company anticipates that this vaccine could be stored at room temperature, potentially facilitating broader distribution.

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FAQ

What is the current stock price of Altimmune (ALT)?

The current stock price of Altimmune (ALT) is $4.745 as of April 1, 2025.

What is the market cap of Altimmune (ALT)?

The market cap of Altimmune (ALT) is approximately 370.1M.

What is the primary focus of Altimmune Inc?

Altimmune Inc is dedicated to developing innovative peptide-based therapeutics for the treatment of obesity, metabolic diseases, and liver conditions such as MASH. Its research is centered around a dual receptor agonist mechanism.

What is pemvidutide and how does it work?

Pemvidutide is an investigational peptide-based GLP-1/glucagon dual receptor agonist. It works by simultaneously activating the GLP-1 receptor to suppress appetite and the glucagon receptor to boost energy expenditure and optimize lipid metabolism.

How is Altimmune positioned within the clinical-stage biopharmaceutical sector?

Altimmune operates in the highly competitive clinical-stage biopharmaceutical space, focusing on unmet medical needs in metabolic and liver diseases. Its novel dual agonist approach distinguishes it from companies with single-target therapies.

What clinical development activities is Altimmune currently undertaking?

The company is actively engaged in clinical trials evaluating the safety, tolerability, and efficacy of pemvidutide in patients with obesity and MASH. Their approach is marked by robust clinical assessments and detailed metabolic profiling.

How does Altimmune’s dual receptor agonist differ from traditional treatments?

Unlike traditional single-target treatments, Altimmune’s dual receptor agonist activates both the GLP-1 and glucagon receptors. This coordinated mechanism helps in achieving effective weight loss while promoting improvements in metabolic markers.

What are some challenges that Altimmune might face in its development process?

As a clinical-stage biopharma, Altimmune faces challenges including regulatory review complexities, clinical trial enrollment, manufacturing scale-up, and overall market competition. These factors are intrinsic to innovative drug development.

Who are the typical competitors in the field of metabolic disease therapeutics?

Competitors typically include other clinical-stage companies and established firms developing treatments for obesity and metabolic disorders. Altimmune differentiates itself with a unique dual receptor approach, targeting multiple pathways concurrently.
Altimmune

OTC:ALT

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ALT Stock Data

370.05M
76.40M
0.84%
53.69%
28.13%
Biotechnology
Pharmaceutical Preparations
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United States
GAITHERSBURG