Welcome to our dedicated page for Alpine Immune Sciences news (Ticker: ALPN), a resource for investors and traders seeking the latest updates and insights on Alpine Immune Sciences stock.
Founded in 2015, Alpine Immune Sciences, Inc. (NASDAQ: ALPN) is a leading clinical-stage biotechnology company dedicated to developing innovative protein-based immunotherapies to treat autoimmune and inflammatory diseases. Alpine leverages its unique understanding of immunology, particularly recombinant protein-based immunotherapies, to modify the complexities of the immune synapse for the benefit of patients living with cancer, autoimmune disorders, and other diseases.
Alpine's standout product, povetacicept (ALPN-303), is a dual antagonist of the BAFF and APRIL cytokines. This product is currently in phase 2 development and has demonstrated potential best-in-class efficacy for treating IgA nephropathy (IgAN). IgAN is a serious, progressive kidney disease with no approved therapies that target its underlying cause. Povetacicept has exhibited promising results in reducing proteinuria, stabilizing renal function, and reducing key disease-related biomarkers.
Additionally, Alpine has a robust pipeline, including acazicolcept (ALPN-101), a first-in-class dual inhibitor targeting the CD28 and ICOS T-cell costimulatory pathways. This drug is being investigated for treating systemic lupus erythematosus (SLE) and other autoimmune diseases. Alpine's research and development capabilities are enhanced by strategic collaborations with leading global biopharmaceutical companies, propelling its efforts to create multifunctional immunotherapies that improve patients' lives.
The company has been highly productive in the past year, achieving significant milestones, such as the phase 2 study of acazicolcept in SLE, a pivotal phase 3 trial of povetacicept in IgAN planned for the second half of 2024, and successful financial activities supporting ongoing and future development projects.
Alpine Immune Sciences remains committed to innovation, with ongoing studies in various autoimmune diseases and strategic goals aligning with its mission to lead a new wave of immune therapeutics.
Alpine Immune Sciences (NASDAQ: ALPN) has announced the initiation of the Synergy Phase 2 study, marking the first patient dosed with ALPN-101 for Systemic Lupus Erythematosus (SLE). The company achieved $45 million in development milestones from a 2020 agreement with AbbVie, part of a potential $730 million in total. ALPN-101, a dual inhibitor of CD28 and ICOS pathways, shows promise based on preclinical studies. The trial, randomized and double-blind, aims to enhance therapeutic outcomes for autoimmune diseases.
Alpine Immune Sciences (NASDAQ: ALPN) announced its inclusion in the Russell 3000® Index, effective June 28, 2021. This annual reconstitution involves the top 4,000 US stocks based on market capitalization. Membership in the Russell 3000® also grants automatic inclusion in the small-cap Russell 2000® Index and associated style indexes. The company aims to develop innovative immunotherapy treatments for cancer and autoimmune diseases, supported by a strong R&D team and strategic collaborations.
Alpine Immune Sciences (NASDAQ:ALPN) presented initial data from the NEON-1 Phase 1 trial of ALPN-202 at the ASCO Virtual Annual Meeting. This first-in-human study evaluates ALPN-202, a novel CD28 costimulator and dual checkpoint inhibitor, in patients with advanced malignancies. Key findings include general tolerability of the drug, with 61% of evaluable participants showing clinical benefit. Notably, one patient with metastatic colorectal cancer achieved an unconfirmed partial response. These results encourage further development of ALPN-202.
Alpine Immune Sciences, Inc. (NASDAQ:ALPN) presented preclinical data for ALPN-303 at the EULAR Congress, highlighting its potential in treating systemic lupus erythematosus and other autoimmune diseases. The data demonstrated that ALPN-303 showed greater efficacy than existing therapies, inhibiting cytokine activity and improving pharmacokinetics. In mouse models, it significantly reduced harmful antibodies and inflammation while preserving kidney function. The company plans to initiate first-in-human studies later this year, reflecting strong interest in its therapeutic approach.
Alpine Immune Sciences (NASDAQ:ALPN) announces the appointment of Zelanna Goldberg, M.D., M.A.S., as Chief Medical Officer. Dr. Goldberg, previously a senior VP at Iovance Biotherapeutics, brings over 20 years of experience in clinical development. She will lead the clinical strategy for ALPN’s promising pipeline, which includes ALPN-101, ALPN-202, and ALPN-303. As part of her inducement, she received an option to purchase 160,000 shares, vesting over four years. This strategic hiring aims to enhance the company's capabilities in addressing cancer and autoimmune diseases.
Alpine Immune Sciences (NASDAQ:ALPN) announced an investor event on June 4, 2021, at 7:00 PM ET, aligned with the 2021 ASCO Virtual Annual Meeting. The event will feature data presentation from the NEON-1 Phase 1 trial of ALPN-202, a promising immunotherapy for advanced malignancies. Attendees can join via phone or live webcast. A replay will be available for 90 days post-event. ALPN-202 is a first-in-class treatment showing superior efficacy in preclinical studies. The company plans to initiate NEON-2, a combination study of ALPN-202 and a PD-1 inhibitor, later this year.
Alpine Immune Sciences, Inc. (NASDAQ:ALPN) announced an oral presentation of preclinical data on its ALPN-303 program at the EULAR European Congress of Rheumatology from June 2-5, 2021. The presentation, titled ALPN-303, an Enhanced, Potent Dual BAFF/APRIL Antagonist, focuses on treating systemic lupus erythematosus and other B cell-related autoimmune diseases. The session is scheduled for June 2 at 4:25 PM CEST (10:25 AM EDT). ALPN-303 is designed to inhibit key cytokines involved in B cell-related diseases, offering potential therapeutic benefits to patients.
Alpine Immune Sciences, Inc. (NASDAQ: ALPN) reported its first-quarter results for 2021, highlighting progress in its clinical pipeline, including the upcoming NEON-1 clinical data update at ASCO. The company has $115.4 million in cash and reported collaboration revenue of $3.2 million, an increase from $1.1 million the previous year. Net losses rose to $10.6 million from $5.5 million. R&D expenses increased to $10.4 million due to clinical trial activities, while general and administrative expenses reached $3.3 million, reflecting growth-related costs.
Alpine Immune Sciences, Inc. (NASDAQ:ALPN) will present data from its Phase 1 clinical trial, NEON-1, focusing on ALPN-202 monotherapy at the ASCO Virtual Annual Meeting from June 4-8, 2021. The presentation titled 'First-in-human dose escalation of ALPN-202' will provide an update on the trial results, which involve a dual checkpoint inhibitor aimed at advanced malignancies. ALPN-202 has shown promising preclinical efficacy compared to conventional checkpoint inhibitors. The company also plans to initiate NEON-2, a combination study with a PD-1 inhibitor, within the year.
Alpine Immune Sciences (NASDAQ:ALPN) presented two significant oncology posters at the AACR Virtual Annual Meeting I, April 10-15, 2021. The first highlights the NEON-1 Phase I trial of ALPN-202, focusing on advanced malignancies, with no dose-limiting toxicities reported. The second showcases engineered fusion proteins that enhance tumor immune responses. President Stanford Peng expressed optimism about advancing clinical data for ALPN-202 in future meetings, reflecting the company's commitment to innovative immunotherapy solutions.
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