Alpine Immune Sciences Provides Corporate Update and Reports First Quarter 2021 Financial Results
Alpine Immune Sciences, Inc. (NASDAQ: ALPN) reported its first-quarter results for 2021, highlighting progress in its clinical pipeline, including the upcoming NEON-1 clinical data update at ASCO. The company has $115.4 million in cash and reported collaboration revenue of $3.2 million, an increase from $1.1 million the previous year. Net losses rose to $10.6 million from $5.5 million. R&D expenses increased to $10.4 million due to clinical trial activities, while general and administrative expenses reached $3.3 million, reflecting growth-related costs.
- Collaboration revenue increased to $3.2 million from $1.1 million YoY.
- Cash resources of $115.4 million are sufficient to fund operations through 2023.
- Progress in the pipeline with imminent Phase 2 study of ALPN-101 and upcoming NEON-1 clinical data presentation.
- Net losses increased to $10.6 million from $5.5 million YoY.
- R&D expenses rose significantly to $10.4 million, indicating higher operational costs.
Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune/inflammatory diseases, today provided a corporate update and reported financial results for the first quarter ended March 31, 2021.
“The first quarter of this year has been highly productive as we continue to make strong progress across our pipeline. We look forward to sharing the first clinical data update on NEON-1, a Phase 1 dose escalation and expansion study of ALPN-202 monotherapy, at the upcoming ASCO Annual Meeting,” said Mitchell H. Gold, M.D., Executive Chairman and Chief Executive Officer of Alpine. “In addition, we continue our focus on the imminent global Phase 2 study of ALPN-101 in systemic lupus erythematosus, targeted to initiate around the middle of the year.”
First Quarter 2021 and Recent Updates
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ALPN-202: Conditional CD28 costimulator and dual checkpoint inhibitor
- In April 2021, at the 2021 American Association for Cancer Research (AACR) Virtual Annual Meeting I, Dr. Mark Voskoboynik from Nucleus Network and The Alfred Hospital in Melbourne, Australia, presented a Trials in Progress poster describing the ongoing first-in-human, Phase 1 clinical trial involving monotherapy with ALPN-202, the company’s lead oncology program.
- In April 2021, Alpine announced an upcoming clinical data presentation on NEON-1 at the American Society of Clinical Oncology (ASCO) Annual Meeting scheduled to take place June 4, 2021.
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Research
- In April 2021, at the 2021 American Association for Cancer Research (AACR) Virtual Annual Meeting I, Alpine researchers demonstrated the use of directed evolution to engineer novel variant immunoglobulin domain (vIgD) Fc fusion proteins that enable tumor antigen-dependent CD28 costimulation.
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General Corporate
- Promotion of Remy Durand, Ph.D. to Chief Business Officer: Dr. Durand joined Alpine Immune Sciences in 2018 as Vice President, Business Development and Corporate Strategy, and has played a leading role in building the company’s partnerships with AbbVie and Adaptimmune, and has represented the company at investor meetings and conferences.
- Appointed Pamela Holland, Ph.D. as Senior Vice President, Research: Dr. Holland is an experienced cancer biologist with a proven track record of successfully discovering and progressing multiple preclinical therapeutics into clinical development, most recently at Surface Oncology and Amgen.
First Quarter 2021 Financial Results
As of March 31, 2021, we had cash, cash equivalents, restricted cash, and investments totaling
Collaboration revenue for the quarter ended March 31, 2021 was
Research and development expenses for the quarter ended March 31, 2021 were
General and administrative expenses for the quarter ended March 31, 2021 were
Alpine expects that its current cash resources, combined with the potential
About Alpine Immune Sciences, Inc.
Alpine Immune Sciences, Inc. is committed to leading a new wave of immune therapeutics. With world-class research and development capabilities, a highly productive scientific platform, and a proven management team, Alpine is seeking to create first- or best-in-class multifunctional immunotherapies via unique protein engineering technologies to improve patients’ lives. Alpine has entered into strategic collaborations with leading global biopharmaceutical companies and has a diverse pipeline of clinical and preclinical candidates in development. For more information, visit www.alpineimmunesciences.com. Follow @AlpineImmuneSci on Twitter and LinkedIn.
Forward-Looking Statements
This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. These forward-looking statements are not based on historical fact and include statements regarding our platform technology and potential therapies, the timing of and results from clinical trials and preclinical development activities, clinical and regulatory objectives and the timing thereof, expectations regarding the sufficiency of cash combined with the potential
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