Alpine Immune Sciences Presents First Preclinical Data for Povetacicept in Myasthenia Gravis at the American Neurological Association Annual Meeting
- Povetacicept treatment led to statistically significant reductions in clinical scores, anti-AChR IgG, and serum Ig in murine EAMG model
- Povetacicept well tolerated in adult healthy volunteers with dose-related effects
- Strong rationale for advancement of povetacicept in myasthenia gravis and related diseases
- None.
Presentation highlights include:
- In a model of murine experimental autoimmune myasthenia gravis (EAMG), povetacicept treatment initiated after disease onset led to statistically significant reductions, as compared to Fc control treatment, in clinical scores, anti-AChR IgG, and serum Ig.
- Povetacicept was well tolerated in adult healthy volunteers as single intravenous or subcutaneous doses of up to 960 mg and exhibited dose-related pharmacokinetic and pharmacodynamic effects, including reductions in circulating Ig and antibody-secreting cells. The results support the use of an every four-week subcutaneous dosing regimen in future studies.
“Together, these data provide strong rationale for the advancement of povetacicept in myasthenia gravis and other autoimmune and/or autoantibody-related neurological conditions,” said Stanford Peng, MD PhD, President and Head of Research and Development at Alpine. “There is a clear need for more safe, efficacious, and conveniently dosed therapies for myasthenia gravis and related diseases, and we look forward to the future opportunity to include them in the povetacicept development program.”
ANA 2023 Poster Presentation Details
Date: September 11, 2023
Poster Title: Povetacicept (ALPN-303), a potent dual BAFF/APRIL antagonist for the treatment of myasthenia gravis and other antibody-related neurological diseases
Poster Number: M135
Link to Poster Presentation: https://bit.ly/3RiIZT1
About Povetacicept (ALPN-303)
Povetacicept (ALPN-303) is a dual antagonist of the BAFF (B cell activating factor) and APRIL (a proliferation inducing ligand) cytokines, which play key roles in pathogenesis of multiple autoimmune diseases via their roles in the activation, differentiation and/or survival of B cells, particularly antibody-secreting cells, as well as T cells and innate immune cells. Based upon an engineered TACI (transmembrane activator and CAML interactor) domain, povetacicept has exhibited greater potency in preclinical studies versus wild-type TACI-based comparators, as well as other inhibitors of BAFF and/or APRIL alone. Povetacicept is in development for multiple autoimmune diseases, such as systemic lupus erythematosus, autoimmune glomerulonephritis, and autoimmune cytopenias.
About Alpine Immune Sciences
Alpine Immune Sciences is committed to leading a new wave of immune therapeutics. With world-class research and development capabilities, a highly productive scientific platform, and a proven management team, Alpine is seeking to create first- or best-in-class multifunctional immunotherapies via unique protein engineering technologies to improve patients’ lives. Alpine has entered into strategic collaborations with leading global biopharmaceutical companies and has a diverse pipeline of clinical and preclinical candidates in development. For more information, visit www.alpineimmunesciences.com. Follow @AlpineImmuneSci on Twitter and LinkedIn.
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Media and Investor Relations Contact:
Temre Johnson
Alpine Immune Sciences, Inc.
ir@alpineimmunesciences.com
media@alpineimmunesciences.com
Source: Alpine Immune Sciences, Inc.
