Column Group funds report SRZN insider purchases on Form 4

Rhea-AI Filing Summary

Surrozen, Inc. (SRZN) reported insider activity by investment funds affiliated with The Column Group. On 11/13/2025, TCG III LP bought 148,150 shares of Surrozen common stock at $12.65 per share, bringing its indirectly held stake to 852,482 shares. On the same date, TCG III-A LP bought 167,307 shares at $12.65 per share, increasing its indirectly held position to 962,718 shares. Another affiliated fund, TCG Opportunity III LP, is shown as indirectly holding 344,827 shares with no new transaction reported in this excerpt.

The Column Group entities report their holdings as indirect beneficial owners, with their general partners and managing members, including Surrozen director Tim Kutzkey, disclaiming beneficial ownership except to the extent of their pecuniary interest. The report is filed jointly by multiple related investment vehicles, reflecting a significant, coordinated ownership position in Surrozen.

Insider Trade Summary

Net Buyer: 315,457 shares ($3,990,531)

Net Buy 3 txns

Insider COLUMN GROUP III GP, LP, COLUMN GROUP III-A, LP, COLUMN GROUP III, LP, Column Group Opportunity III, LP, Column Group Opportunity III GP, LP, TCG Opportunity III GP, LLC

Role 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner

Bought 315,457 shs ($3.99M)

Type	Security	Shares	Price	Value
Purchase	Common Stock	148,150	$12.65	$1.87M
Purchase	Common Stock	167,307	$12.65	$2.12M
holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 852,482 shares (Indirect, By The Column Group III, LP)

Footnotes (1)

1. The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey, a member of the Issuer's board of directors (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities. The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities. The securities are directly held by TCG Opportunity III LP. The Column Group Opportunity III GP, LP ("TCG Opportunity III GP LP") is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP, LLC ("TCG Opportunity III GP LLC") is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing members of TCG Opportunity III GP LLC are David Goeddel, Peter Svennilson and Tim Kutzkey, a member of the Issuer's board of directors (collectively, the "Managing Members"). TCG Opportunity III GP LP, TCG Opportunity III GP LLC and each of the Managing Members disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

COLUMN GROUP III GP, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Surrozen, Inc./DE [ SRZN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
11/13/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/13/2025		P		148,150	A	$12.65	852,482	I	By The Column Group III, LP(1)
Common Stock	11/13/2025		P		167,307	A	$12.65	962,718	I	By The Column Group III-A, LP(2)
Common Stock								344,827	I	By The Column Group Opportunity III, LP(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

COLUMN GROUP III GP, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

COLUMN GROUP III-A, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

COLUMN GROUP III, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Column Group Opportunity III, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Column Group Opportunity III GP, LP

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

TCG Opportunity III GP, LLC

(Last) (First) (Middle)

1 LETTERMAN DR., BLDG D, SUITE DM-900

(Street)

SAN FRANCISCO CA 94129

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey, a member of the Issuer's board of directors (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.

2. The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.

3. The securities are directly held by TCG Opportunity III LP. The Column Group Opportunity III GP, LP ("TCG Opportunity III GP LP") is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP, LLC ("TCG Opportunity III GP LLC") is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing members of TCG Opportunity III GP LLC are David Goeddel, Peter Svennilson and Tim Kutzkey, a member of the Issuer's board of directors (collectively, the "Managing Members"). TCG Opportunity III GP LP, TCG Opportunity III GP LLC and each of the Managing Members disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.

	/s/ The Column Group III GP, LP /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	/s/ The Column Group III-A, LP. by The Column Group III GP, LP, its general partner /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	/s/ The Column Group III, LP by The Column Group III GP, LP, its general partner /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	/s/ The Column Group Opportunity III, LP /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	/s/ The Column Group Opportunity III GP, LP. by /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	/s/ TCG Opportunity III GP, LLC by /s/ James Evangelista, Attorney-in-Fact	11/17/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transactions in SRZN are reported in this Form 4?

The report shows that on 11/13/2025, TCG III LP bought 148,150 shares of Surrozen common stock at $12.65 per share and TCG III-A LP bought 167,307 shares at the same price.

How many Surrozen (SRZN) shares do the Column Group funds hold after these trades?

After the reported transactions, TCG III LP beneficially owns 852,482 shares and TCG III-A LP beneficially owns 962,718 shares. TCG Opportunity III LP is shown as beneficially owning 344,827 shares.

Who is the reporting owner in this Surrozen (SRZN) Form 4?

The reporting owners are investment funds affiliated with The Column Group, including TCG III LP, TCG III-A LP and TCG Opportunity III LP, along with their general partners and managing entities.

What is the relationship of the reporting persons to Surrozen (SRZN)?

The reporting persons are identified as a director and 10% owner of Surrozen through their affiliated entities. Tim Kutzkey, one of the managing partners or members, serves on Surrozen's board of directors.

Do the Column Group managers claim full beneficial ownership of the SRZN shares?

No. The general partners and managing partners or members, including the entities controlling the funds, disclaim beneficial ownership of the Surrozen shares except to the extent of their respective pecuniary interest.

Was this Surrozen (SRZN) Form 4 filed by multiple reporting persons?

Yes. The report is indicated as a Form filed by more than one reporting person, reflecting several related Column Group entities signing through an attorney-in-fact.