Opaleye-managed funds report Sol-Gel Technologies (SLGL) share purchase

Rhea-AI Filing Summary

Sol-Gel Technologies Ltd. had an insider ownership update involving entities managed by Opaleye Management Inc. On February 2, 2026, Opaleye, L.P. purchased 100 ordinary shares of Sol-Gel at $58 per share, bringing its indirectly held position to 450,944 ordinary shares. A separately managed account overseen by Opaleye Management holds an additional 10,000 ordinary shares indirectly. Opaleye Management Inc. states that it may be deemed to beneficially own these securities but disclaims beneficial ownership beyond its pecuniary interest.

Insider Trade Summary

Net Buyer: 100 shares ($5,800)

Net Buy 2 txns

Insider Opaleye Management Inc.

Role 10% Owner

Bought 100 shs ($6K)

Type	Security	Shares	Price	Value
Purchase	Ordinary Shares, par value NIS 1.00 per share.	100	$58.00	$6K
holding	Ordinary Shares, par value NIS 1.00 per share.	--	--	--

Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share. — 450,944 shares (Indirect, By Opaleye, L.P.)

Footnotes (1)

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MA 02108

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
02/02/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares, par value NIS 1.00 per share.	02/02/2026		P		100	A	$58	450,944	I	By Opaleye, L.P.(1)(3)
Ordinary Shares, par value NIS 1.00 per share.								10,000	I	By Managed Account(2)(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

3. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management Inc., By: /s/ James Silverman, President	02/04/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction was reported for Sol-Gel Technologies (SLGL)?

A fund managed by Opaleye reported buying 100 Sol-Gel ordinary shares at $58 on February 2, 2026. This transaction increased the indirect holdings of Opaleye, L.P. to 450,944 ordinary shares, with a separate managed account showing an additional 10,000 shares held.

Who is the reporting person on this Sol-Gel Technologies (SLGL) Form 4?

The reporting person is Opaleye Management Inc., a ten percent owner of Sol-Gel Technologies. The shares are held indirectly through Opaleye, L.P. and a separately managed account, for which Opaleye acts as investment manager and portfolio manager, respectively, rather than holding the shares directly.

How many Sol-Gel Technologies (SLGL) shares does Opaleye, L.P. hold after the transaction?

After purchasing 100 ordinary shares at $58 on February 2, 2026, Opaleye, L.P. is reported as indirectly holding 450,944 Sol-Gel ordinary shares. These are ordinary shares with a par value of NIS 1.00 per share, owned directly by the fund but reported by Opaleye Management.

What additional Sol-Gel Technologies (SLGL) holdings are reported in the managed account?

A separately managed account overseen by Opaleye Management holds 10,000 Sol-Gel ordinary shares. These shares are reported as being owned directly by the managed account, with Opaleye acting as portfolio manager and therefore potentially deemed a beneficial owner under applicable securities rules.

Does Opaleye Management Inc. claim full beneficial ownership of the Sol-Gel (SLGL) shares?

Opaleye Management Inc. expressly disclaims beneficial ownership of the reported Sol-Gel shares except to the extent of its pecuniary interest. The filing states this should not be taken as an admission that Opaleye Management is the beneficial owner for Section 16(a) or any other purpose.